Search Results - therapy

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Novel HIV Therapeutic Approach: Targeting APOBEC-3G(A3G):RNA Complexes
Brief Description:APOBEC-3G (A3G) is a cytidine deaminase enzyme that interferes with the replication of HIV and other retroviruses by mutating viral nucleic acids, thus playing an important role in innate anti-viral immunity. Viral infectivity factor (Vif) is a protein found in HIV and other retroviruses which disrupts the antiviral activity of the...
Published: 4/29/2019   |   Inventor(s): Harold Smith, Kimberly Prohaska, William McDougall
Keywords(s): AIDS, Antiviral, HIV, Infectious Disease, Therapy, Viral disease
Category(s): Therapeutic
Methods for Production of a Solution Assay and High-Throughput Screen to Probe the Interaction Between the Human Cullin-RING Ligase Complex and the HIV-1 Protein on a Muti-Milligram Scale
Brief Description:HIV-1 infection leads to the expression of the viral Vif protein which is essential to evade the host’s own A3G and A3F defense factors. Vif works in concert with the cell’s own ubiquitin ligase machinery to promote degradation of A3G and A3F. This requires a direct interaction between Vif and the human proteins Elongin...
Published: 4/29/2019   |   Inventor(s): Jason Salter, Joseph Wedekind, Harold Smith
Keywords(s): AIDS, Antiviral, Combinatorial Chemistry, Drug Design, HIV, HTS, Infection, Infectious Disease, Target Validation, Therapy, Viral disease
Category(s): Therapeutic
Method to Prevent HIV Infection by Maintaining APOBEC3G (A3g) in Its More Active “Low Molecular Mass” (LMM) Form
Applications:The more active LMM form of APOBEC3G (A3g) prevents HIV from replicating within the host. Thus maintaining LMM-A3G and preventing the inactive HMM-A3G formation or preventing its degradation by the viral protein, Vif, would limit the ability of HIV to infect its host.Advantages:This technology provides a novel approach to increase the activity...
Published: 4/29/2019   |   Inventor(s): Harold Smith, Joseph Wedekind
Keywords(s): AIDS, Antiviral, HIV, RNA, Therapy
Category(s): Therapeutic
Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System
Applications:Activated protein C (APC), pro-drug, and/or a variant thereof may be used as an inhibitor of apoptosis or cell death and/or a cell survival factor, especially for stressed or injured cells or tissues of the nervous system including subjects with neurodegenerative disorders.Advantages:Novel biological functions (e.g., neuroprotection) can...
Published: 4/29/2019   |   Inventor(s): Berislav Zlokovic, John Griffin
Keywords(s): Aging, Alzheimer's, Neurological, Therapy
Category(s): Therapeutic
Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Applications:The invention is a method of enhancing endogenous interleukin-10 production in mammalian cells and tissues, which includes administering an effective amount of a tetracycline derivative. Advantages:The method also includes enhancing interleukin-10 production by administering an effective amount of the tetracycline derivative to a mammal....
Published: 4/29/2019   |   Inventor(s): Lorne Golub, Christopher Ritchlin, Robert Greenwald, Sally Haas, Susan Moak, Hsi-Ming Lee
Keywords(s): Infectious Disease, Therapy
Category(s): Therapeutic
Vaccine against Pneumocystis and Streptococcal Infections
Novel polypeptides and immunogenic conjugates capable of inducing passive and active immunity against Pneumocystis carinii and Streptococcus pneumoniae infections.Problem Solved by this TechnologyPneumocystis pneumonia (PCP), caused by an opportunistic pathogen Pneumocystis carinii, is a significant cause of morbidity and mortality in immunocompromised...
Published: 9/21/2016   |   Inventor(s): Francis Gigliotti, Terry Wright, Constantine Haidaris, Patricia Simpson-Haidaris
Keywords(s): Antibody, Infectious Disease, Therapy
Category(s): Vaccines
Biliverdin Reductase (BVR) Peptides That Inhibit PCK-delta for the Potential Treatment of Cancer and Inflammation
Applications: Dr. M. Maines is a leading expert in BVR research and has uncovered many applications for this enzyme. In this invention she has linked BVR to modulation of PKC and found potent inhibitory peptides that may have utility in both understanding and treating cancer. A multiplicity of functions has been ascribed to PKC. Recurring themes...
Published: 7/22/2011   |   Inventor(s): Mahin Maines
Keywords(s): Cancer, Oncology, Peptide, Protein, Target Validation, Therapy
Category(s): Therapeutic
Monoclonal Antibodies to Dengue Fever NS1
ApplicationsThis invention presents serious of monoclonal mouse IgG and IgM antibodies against yellow fever virus and dengue fever, and the antibody-producing hybridoma cell lines. These antibodies have multiple applications in production of vaccine against yellow fever.AdvantagesThese antibodies have been proved to be very helpful in testing, quality...
Published: 6/17/2009   |   Inventor(s): Jacob Schlesinger
Keywords(s): Antiviral, Therapy
Category(s): Research Tools
Monoclonal Antibodies to Dengue Fever E Protein
ApplicationsThis invention presents serious of monoclonal mouse IgG and IgM antibodies against yellow fever virus and dengue fever, and the antibody-producing hybridoma cell lines. These antibodies have multiple applications in production of vaccine against yellow fever.AdvantagesThese antibodies have been proved to be very helpful in testing, quality...
Published: 6/17/2009   |   Inventor(s): Jacob Schlesinger
Keywords(s): Antiviral, Therapy
Category(s): Research Tools
Human KC-NL Crosstalk Subversion by HCV
Applications:The invention has developed an in vitro culture system based on the isolation of human Kupffer cells (KC) and natural Killer Cells (NK) from the donated liver grafts. The model can be used for the identification of drug targets of viral hepatitis, and for testing drugs and biologics.Advantages:The model uses human cells directly from the...
Published: 6/17/2009   |   Inventor(s): Mark Orloff, Ian Nicholas Crispe
Keywords(s): Cell Signalling, Immunology, Research Tool, Therapy
Category(s): Research Tools
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