Search Results - therapy

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RNA-Targeted Small Molecules as Potential Antiviral Therapy (HIV, SARS etc)

Brief Description: A high error rate of HIV -I reverse transcriptase coupled with a fast replication cycle associated with HIV -1 favors rapid development and selection of drug resistant strains. Therefore, identification of small molecules capable of inhibiting viral components necessary for HIV -1 proliferation continues to be of great importance....

Published: 9/19/2023 | Inventor(s): Benjamin Miller, Brian Mcnaughton, Peter Gareiss, Joseph Wedekind

Keywords(s): AIDS, HIV, Small Molecule, Therapy

Category(s): Therapeutic

Protease Activated Cytokines as Anti-Cancer Therapy

A novel therapy method for delivering localized anti-cancer responses without adverse body-wide side effects. Problem Solved by the Technology Despite remarkable success at identifying tumor-associated antigens (TAA), generating effective anti-tumor immune response has not been successful at eliminating tumors. Systemically administered active drugs...

Published: 9/19/2023 | Inventor(s): John Frelinger, John Puskas, Baek Kim, Mark Sullivan

Keywords(s): Cancer, Immunotherapy, Oncology, Therapy

Category(s): Therapeutic

Application for retraining and evaluating a patient's damaged visual system (either cortical or subcortical)

Background There are 4.5 million stroke victims in the United States, with 750,000 new cases each year. Among them, 15‑20% have serious vision loss. However, currently, each of the patients is sent home with essentially no treatment options to restore or improve their loss of sight. Technology Overview Researchers at the University of Rochester have...

Published: 2/14/2024 | Inventor(s): Krystel Huxlin, Mary Hayhoe, Jeff Pelz

Keywords(s): Software, Therapy, Vision

Category(s): Therapeutic, Computer Software

Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System

Applications:Activated protein C (APC), pro-drug, and/or a variant thereof may be used as an inhibitor of apoptosis or cell death and/or a cell survival factor, especially for stressed or injured cells or tissues of the nervous system including subjects with neurodegenerative disorders.Advantages:Novel biological functions (e.g., neuroprotection) can...

Published: 12/5/2023 | Inventor(s): Berislav Zlokovic, John Griffin

Keywords(s): Aging, Alzheimer's, Neurological, Therapy

Category(s): Therapeutic

Biliverdin Reductase (BVR) Peptides That Inhibit PCK-delta for the Potential Treatment of Cancer and Inflammation

Applications: Dr. M. Maines is a leading expert in BVR research and has uncovered many applications for this enzyme. In this invention she has linked BVR to modulation of PKC and found potent inhibitory peptides that may have utility in both understanding and treating cancer. A multiplicity of functions has been ascribed to PKC. Recurring...

Published: 5/23/2023 | Inventor(s): Mahin Maines

Keywords(s): Cancer, Oncology, Peptide, Protein, Target Validation, Therapy

Category(s): Therapeutic

Monoclonal Antibodies to Dengue Fever NS1

ApplicationsThis invention presents serious of monoclonal mouse IgG and IgM antibodies against yellow fever virus and dengue fever, and the antibody-producing hybridoma cell lines. These antibodies have multiple applications in production of vaccine against yellow fever.AdvantagesThese antibodies have been proved to be very helpful in testing, quality...

Published: 5/23/2023 | Inventor(s): Jacob Schlesinger

Keywords(s): Antiviral, Therapy

Category(s): Research Tools

Monoclonal Antibodies to Dengue Fever E Protein

Published: 5/23/2023 | Inventor(s): Jacob Schlesinger

Keywords(s): Antiviral, Therapy

Category(s): Research Tools

Human KC-NL Crosstalk Subversion by HCV

Applications:The invention has developed an in vitro culture system based on the isolation of human Kupffer cells (KC) and natural Killer Cells (NK) from the donated liver grafts. The model can be used for the identification of drug targets of viral hepatitis, and for testing drugs and biologics.Advantages:The model uses human cells directly from the...

Published: 8/14/2023 | Inventor(s): Mark Orloff, Ian Nicholas Crispe

Keywords(s): Cell Signalling, Immunology, Research Tool, Therapy

Category(s): Research Tools

Modulating Melanin Expression

Compounds which can induce melanin expression to aid in certain clinical indications or for cosmetic purposes.Problem Solved by This TechnologyMelanin is important for disease prevention, because it absorbs ultraviolet light in the UVB and UVA spectrum. This protects keratinocytes from the mutagenic effects of sunlight. In addition, melanin has a social...

Published: 2/14/2024 | Inventor(s): Benjamin Miller, Brian Mcnaughton, Peter Gareiss, Glynis Scott

Keywords(s): Cancer, Dermatology, Oncology, Small Molecule, Therapy

Category(s): Therapeutic

Reagents Identifying PPARγ Isoforms

Applications:Reagents can be used for commercial western blot/ELISA/Flow Cytometry.Advantages:Currently there are no proven reagents that distinguish PPAR gamma isoforms.

Published: 5/23/2023 | Inventor(s): Richard Phipps

Keywords(s): Cell Signalling, Therapy

Category(s): Research Tools

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