Search Results - therapeutic

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Novel Treatment for Acute and Traumatic Nerve Injury
Brief description:This invention provides a novel method for the localized and effective administration of a small molecule for the treatment of acute peripheral nerve injuries.Applications:Injury to the peripheral nerves can occur through a variety of trauma. Common causes of these injuries include: laceration, focal contusion (gunshot wounds), s...
Published: 4/29/2019   |   Inventor(s): John Elfar, Mark Noble, Kuang-Ching Tseng
Keywords(s): Neurological, Orthopaedics
Category(s): Therapeutic
Light-Controlled Immunotherapy
A novel therapy using light-activated chemokine receptors to direct specific lymphocytes to desired locations within a patient's body.Problem Solved by the TechnologyMost current cancer treatments are delivered systemically, and are usually associated with undesirable side-effects, including nausea, hair loss, and weakness.ApplicationsDr. Minsoo Ki...
Published: 4/29/2019   |   Inventor(s): Minsoo Kim
Keywords(s): Anti-inflammatory, Autoimmune
Category(s): Therapeutic
3' Deoxy Nucleosides and Their Analogs as Anti-HIV Agents Targeting HIV-1 Macrophage Infection
3' Deoxy Nucleosides and Their Analogs as Anti-HIV Agents Targeting HIV-1 Macrophage Infection
Published: 4/29/2019   |   Inventor(s): Baek Kim
Keywords(s): Antiviral, Drug Design, HIV, Infectious Disease
Category(s): Therapeutic
Novel HIV Therapeutic Approach: Targeting APOBEC-3G(A3G):RNA Complexes
Brief Description:APOBEC-3G (A3G) is a cytidine deaminase enzyme that interferes with the replication of HIV and other retroviruses by mutating viral nucleic acids, thus playing an important role in innate anti-viral immunity. Viral infectivity factor (Vif) is a protein found in HIV and other retroviruses which disrupts the antiviral activity of th...
Published: 4/29/2019   |   Inventor(s): Harold Smith, Kimberly Prohaska, William McDougall
Keywords(s): AIDS, Antiviral, HIV, Infectious Disease, Therapy, Viral disease
Category(s): Therapeutic
Methods for Production of a Solution Assay and High-Throughput Screen to Probe the Interaction Between the Human Cullin-RING Ligase Complex and the HIV-1 Protein on a Muti-Milligram Scale
Brief Description:HIV-1 infection leads to the expression of the viral Vif protein which is essential to evade the host’s own A3G and A3F defense factors. Vif works in concert with the cell’s own ubiquitin ligase machinery to promote degradation of A3G and A3F. This requires a direct interaction between Vif and the human proteins Elongi...
Published: 4/29/2019   |   Inventor(s): Jason Salter, Joseph Wedekind, Harold Smith
Keywords(s): AIDS, Antiviral, Combinatorial Chemistry, Drug Design, HIV, HTS, Infection, Infectious Disease, Target Validation, Therapy, Viral disease
Category(s): Therapeutic
The Use of Papillomavirus Virus-Like Particles (VLPs) and Derivatives (including Capsomeres) as Microbicides
Description The present invention makes use of Papillomavirus VLPs as microbicidal agents to prevent or inhibit infection by papillomavirus or other viruses that utilize a shared papillomavirus binding receptor on the surface of cells and tissues. The composition of the microbicide contains a papillomavirus virus-like particle or capsomere that is ...
Published: 4/29/2019   |   Inventor(s): William Bonnez
Keywords(s):  
Category(s): Therapeutic
Method to Prevent HIV Infection by Maintaining APOBEC3G (A3g) in Its More Active “Low Molecular Mass” (LMM) Form
Applications:The more active LMM form of APOBEC3G (A3g) prevents HIV from replicating within the host. Thus maintaining LMM-A3G and preventing the inactive HMM-A3G formation or preventing its degradation by the viral protein, Vif, would limit the ability of HIV to infect its host.Advantages:This technology provides a novel approach to increase the ...
Published: 4/29/2019   |   Inventor(s): Harold Smith, Joseph Wedekind
Keywords(s): AIDS, Antiviral, HIV, RNA, Therapy
Category(s): Therapeutic
Novel Cell Therapy for Treating CNS Injury
A new cell therapy for treating damage to the central nervous system (CNS).Problem Solved by the TechnologyDamage to the CNS, whether through trauma or as a result of a neurodegenerative disease, creates a multitude of problems that include neurotoxicity, loss of synapses, disrupted axon growth, neuroinflammation, and cell death.ApplicationsResearc...
Published: 4/29/2019   |   Inventor(s): Chris Proschel, Margot Mayer-Proschel, Mark Noble, Jeannette Davies, Stephen Davies
Keywords(s): Stem Cell
Category(s): Therapeutic
Protein Transducing Domain/Deaminase Chimeric Proteins, Related Compounds, and Uses Thereof
Applications:Along with 1174, the present invention is directed to provide a chimeric protein capable of transduction into B cells for purposes of treating Class Switch Recombination and Somatic Hypermutation, both involved in antibody production and diversity, as well as other conditions such as B cell lymphoma.
Published: 4/29/2019   |   Inventor(s): Harold Smith, Mark Sowden, Stephen Dewhurst, Baek Kim, Joseph Wedekind
Keywords(s): Cancer, Gene Therapy, Oncology
Category(s): Therapeutic
Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System
Applications:Activated protein C (APC), pro-drug, and/or a variant thereof may be used as an inhibitor of apoptosis or cell death and/or a cell survival factor, especially for stressed or injured cells or tissues of the nervous system including subjects with neurodegenerative disorders.Advantages:Novel biological functions (e.g., neuroprotection) c...
Published: 4/29/2019   |   Inventor(s): Berislav Zlokovic, John Griffin
Keywords(s): Aging, Alzheimer's, Neurological, Therapy
Category(s): Therapeutic
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