Search Results - alzheimer's

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Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System
Applications:Activated protein C (APC), pro-drug, and/or a variant thereof may be used as an inhibitor of apoptosis or cell death and/or a cell survival factor, especially for stressed or injured cells or tissues of the nervous system including subjects with neurodegenerative disorders.Advantages:Novel biological functions (e.g., neuroprotection) can...
Published: 4/29/2019   |   Inventor(s): Berislav Zlokovic, John Griffin
Keywords(s): Aging, Alzheimer's, Neurological, Therapy
Category(s): Therapeutic
A Model to Study the Role of IL-1ß in Neurodegeneration and Brain Injury
Applications:A novel transgenic mouse model was created to investigate the role of IL1ß in neurodegeneration and brain injury. This model may also be used to test existing and novel drugs and therapies for suppression of neuroinflammation associated with brain disorders.Advantages:Creation of conditionally expressed IL1ß and IL-1A (receptor...
Published: 6/17/2009   |   Inventor(s): M. Kerry O'banion, Stephanos Kyrkanides
Keywords(s): Alzheimer's, Research Tool
Category(s): Research Tools
Human-Mouse Chimeric Model to Assess in vivo Response of Human Glial to Injury, Disease Perturbation, and Drug Treatment
Applications:The invention has generated chimeric human-mouse brains in which the relative proportion of human astrocytes and oligodendrocytes is quite high, often exceeding 50% of all cells in the adult white matter. More over, researchers have established mice in which 100% of myelin, in substantially normal myelinated brain, is of human origin.Advantages:In...
Published: 4/13/2009   |   Inventor(s): Steven Goldman, Martha Windrem
Keywords(s): Alzheimer's, in vivo, Mouse, Parkinson's, Research Tool, Stroke
Category(s): Research Tools