Search Results - cell signalling

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Human KC-NL Crosstalk Subversion by HCV
Applications:The invention has developed an in vitro culture system based on the isolation of human Kupffer cells (KC) and natural Killer Cells (NK) from the donated liver grafts. The model can be used for the identification of drug targets of viral hepatitis, and for testing drugs and biologics.Advantages:The model uses human cells directly from the...
Published: 6/17/2009   |   Inventor(s): Mark Orloff, Ian Nicholas Crispe
Keywords(s): Cell Signalling, Immunology, Research Tool, Therapy
Category(s): Research Tools
Protein Kinase C-Associated Kinase PKK is Required for NF-kB Signaling and Survival in Diffuse Large-B Cell Lymphoma Cells
Applications:This invention provides a novel drug target for the treatment of B-cell lymphoma. NFkB plays an important role in the proliferation and the survival of many types of B lymphoma cells. Inhibition of the novel target will lead to inactivation of transcript factor NFkB in specific cell targets and cause certain types of B lymphoma cells...
Published: 6/17/2009   |   Inventor(s): Luojing Chen, Jiyong Zhao
Keywords(s): Cancer, Cell Signalling, Immunology, Oncology, Therapy
Category(s): Therapeutic
Reagents Identifying PPARγ Isoforms
Applications:Reagents can be used for commercial western blot/ELISA/Flow Cytometry.Advantages:Currently there are no proven reagents that distinguish PPAR gamma isoforms.
Published: 6/17/2009   |   Inventor(s): Richard Phipps
Keywords(s): Cell Signalling, Therapy
Category(s): Research Tools
Human Biliverdin Reductase is a New Member of the Insulin Receptor Substrate Family with Serine/Threonine/Tyrosine Kinase Activity
Applications:Human biliverdin reductase (BVR) is an evolutionary conserved soluble enzyme that was originally characterized in the context of its reductase activity (conversion of biliverdin to bilirubin) and more recently shown to possess serine/threonine/tyrosine kinase activity. The present work demonstrates that this dual kinase activity of BVR...
Published: 6/17/2009   |   Inventor(s): Mahin Maines
Keywords(s): Cell Signalling, Therapy
Category(s): Therapeutic