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Protease Activated Cytokines as Anti-Cancer Therapy
A novel therapy method for delivering localized anti-cancer responses without adverse body-wide side effects. Problem Solved by the Technology Despite remarkable success at identifying tumor-associated antigens (TAA), generating effective anti-tumor immune response has not been successful at eliminating tumors. Systemically administered active drugs...
Published: 10/28/2024
|
Inventor(s):
John Frelinger
,
John Puskas
,
Baek Kim
,
Mark Sullivan
Keywords(s):
Cancer
,
Immunotherapy
,
Oncology
,
Therapy
Category(s):
Therapeutic
Human Glandular Kallikrein (hK2)-Specific Monoclonal Antibodies that Enhance or Inhibit the Enzymatic Activity of hK2
Applications:hK2 is expressed primarily in the prostate, making it an attractive bio-marker for prostate cancer development. A panel of HK2-specific monoclonal antibodies was produced using a tumor-immunization strategy. Compositions, which may be monoclonal antibodies, are specific for hK2 relative to PSA. Compositions either enhance or inhibit...
Published: 10/28/2024
|
Inventor(s):
John Frelinger
,
Terrence Fisher
,
Mary Ann Nocera-March
,
Edith Lord
Keywords(s):
Category(s):
Research Tools
Transgenic Mice Expressing Human PSA
ApplicationsHuman prostate-specific antigen (PSA) has been widely used as a serum marker for cancer of the prostate. The cell type-specific expression of PSA also makes it a potential tumor antigen for prostate cancer immunotherapy.AdvantagesGeneration of a mouse model expressing human PSA allows for the study of the immunological aspects of this protein...
Published: 10/28/2024
|
Inventor(s):
John Frelinger
,
Chungwen Wei
,
Richard Barth
Keywords(s):
Research Tool
Category(s):
Research Tools