Search Results - antiviral

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3' Deoxy Nucleosides and Their Analogs as Anti-HIV Agents Targeting HIV-1 Macrophage Infection
3' Deoxy Nucleosides and Their Analogs as Anti-HIV Agents Targeting HIV-1 Macrophage Infection
Published: 4/29/2019   |   Inventor(s): Baek Kim
Keywords(s): Antiviral, Drug Design, HIV, Infectious Disease
Category(s): Therapeutic
Novel HIV Therapeutic Approach: Targeting APOBEC-3G(A3G):RNA Complexes
Brief Description:APOBEC-3G (A3G) is a cytidine deaminase enzyme that interferes with the replication of HIV and other retroviruses by mutating viral nucleic acids, thus playing an important role in innate anti-viral immunity. Viral infectivity factor (Vif) is a protein found in HIV and other retroviruses which disrupts the antiviral activity of th...
Published: 4/29/2019   |   Inventor(s): Harold Smith, Kimberly Prohaska, William McDougall
Keywords(s): AIDS, Antiviral, HIV, Infectious Disease, Therapy, Viral disease
Category(s): Therapeutic
Methods for Production of a Solution Assay and High-Throughput Screen to Probe the Interaction Between the Human Cullin-RING Ligase Complex and the HIV-1 Protein on a Muti-Milligram Scale
Brief Description:HIV-1 infection leads to the expression of the viral Vif protein which is essential to evade the host’s own A3G and A3F defense factors. Vif works in concert with the cell’s own ubiquitin ligase machinery to promote degradation of A3G and A3F. This requires a direct interaction between Vif and the human proteins Elongi...
Published: 4/29/2019   |   Inventor(s): Jason Salter, Joseph Wedekind, Harold Smith
Keywords(s): AIDS, Antiviral, Combinatorial Chemistry, Drug Design, HIV, HTS, Infection, Infectious Disease, Target Validation, Therapy, Viral disease
Category(s): Therapeutic
Method to Prevent HIV Infection by Maintaining APOBEC3G (A3g) in Its More Active “Low Molecular Mass” (LMM) Form
Applications:The more active LMM form of APOBEC3G (A3g) prevents HIV from replicating within the host. Thus maintaining LMM-A3G and preventing the inactive HMM-A3G formation or preventing its degradation by the viral protein, Vif, would limit the ability of HIV to infect its host.Advantages:This technology provides a novel approach to increase the ...
Published: 4/29/2019   |   Inventor(s): Harold Smith, Joseph Wedekind
Keywords(s): AIDS, Antiviral, HIV, RNA, Therapy
Category(s): Therapeutic
Inducing Immune Responses Using Platelets
Brief Description: The use of patients own dendritic cells pulsed with a specific antigen to induce T-cells responses and induction of memory T-cells is widely known as an approach for stimulating the immune system in individualized medicine. This approach entails isolation of monocytes from the blood (where their numbers are relatively low) ...
Published: 10/12/2012   |   Inventor(s): Craig Morrell
Keywords(s): Antibacterial, Antiviral, Cancer, Infection, Infectious Disease, Research Tool
Category(s): Vaccines, Therapeutic
Monoclonal Antibodies to Dengue Fever NS1
ApplicationsThis invention presents serious of monoclonal mouse IgG and IgM antibodies against yellow fever virus and dengue fever, and the antibody-producing hybridoma cell lines. These antibodies have multiple applications in production of vaccine against yellow fever.AdvantagesThese antibodies have been proved to be very helpful in testing, qual...
Published: 6/17/2009   |   Inventor(s): Jacob Schlesinger
Keywords(s): Antiviral, Therapy
Category(s): Research Tools
Monoclonal Antibodies to Dengue Fever E Protein
ApplicationsThis invention presents serious of monoclonal mouse IgG and IgM antibodies against yellow fever virus and dengue fever, and the antibody-producing hybridoma cell lines. These antibodies have multiple applications in production of vaccine against yellow fever.AdvantagesThese antibodies have been proved to be very helpful in testing, qual...
Published: 6/17/2009   |   Inventor(s): Jacob Schlesinger
Keywords(s): Antiviral, Therapy
Category(s): Research Tools
Monoclonal Antibodies to Yellow Fever E Protein
Applications:This invention presents serious of monoclonal mouse IgG and IgM antibodies against yellow fever virus and dengue fever, and the antibody-producing hybridoma cell lines. These antibodies have multiple applications in production of vaccine against yellow fever.Advantages:These antibodies have been proved to be very helpful in testing, qu...
Published: 6/17/2009   |   Inventor(s): Jacob Schlesinger
Keywords(s): Antiviral, Therapy
Category(s): Research Tools