Search Results - cancer

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Novel Melampomagnolide-based Anti-Cancer Drugs and Pro-Drugs that Target Leukemia Stem Cells
Brief Description: Adult acute leukemia is an extremely serious disease, resulting in death for the majority of patients. Despite decades of intensive research, long-term cures are obtained for only approximately 30% of patients. Thus, there is an urgent need for the development of treatment regimens that are more efficacious and less toxic to...
Published: 2/26/2019   |   Inventor(s): Craig Jordan, Shanshan Pei
Keywords(s): Blood, Cancer, Leukemia
Category(s): Therapeutic
A Low Cost Device for the Detection of Prostate Cancer in Real Time
An inexpensive device for early detection of prostate cancer.Problem Solved by This TechnologyCurrent Digital Rectal Exams and chemical screening methods, such as PSA, provide statistically inadequate detection of early prostate cancer development. Moreover, these modalities provide no information relating to the location or the extent of malignanc...
Published: 9/3/2014   |   Inventor(s): Stephen Arnold, Vikram Dogra, Navalgund Rao
Keywords(s): Cancer, Diagnostic, Instrument, Instrumentation, Medical Device, Oncology, Prostate, Ultrasound, Ultrasound Imaging
Category(s): Imaging
Inducing Immune Responses Using Platelets
Brief Description: The use of patients own dendritic cells pulsed with a specific antigen to induce T-cells responses and induction of memory T-cells is widely known as an approach for stimulating the immune system in individualized medicine. This approach entails isolation of monocytes from the blood (where their numbers are relatively low) ...
Published: 10/12/2012   |   Inventor(s): Craig Morrell
Keywords(s): Antibacterial, Antiviral, Cancer, Infection, Infectious Disease, Research Tool
Category(s): Vaccines, Therapeutic
New Therapeutic Treatment for Multiple Myeloma and Lymphoma
Brief Description:This invention discloses a new therapeutic method for treating multiple myeloma and lymphoma. Technology Status: In vitro tests have showed that small molecule compounds are effective in suppressing tumor cell growth. New compounds are being identified and tested. In vivo testing in mice has also been planned.
Published: 7/19/2012   |   Inventor(s): Jiyong Zhao
Keywords(s): Cancer, Small Molecule
Category(s): Therapeutic
RNA Modification to Modulate Telomerase Activity
Applications:2’-O-methylation at U809 reduces telomerase activity resulting in telomere shortening, whereas 2’-O-methylation at A804 or A805 leads to moderate telomere lengthening.Advantages:Researchers at the University of Rochester have shown that the use of 2’-O-methylation can be accomplished in vivo and have an effect on telo...
Published: 8/1/2011   |   Inventor(s): Yi-Tao Yu, Chao Huang
Keywords(s): Cancer, Research Tool, RNA
Category(s): Therapeutic
Biliverdin Reductase (BVR) Peptides That Inhibit PCK-delta for the Potential Treatment of Cancer and Inflammation
Applications: Dr. M. Maines is a leading expert in BVR research and has uncovered many applications for this enzyme. In this invention she has linked BVR to modulation of PKC and found potent inhibitory peptides that may have utility in both understanding and treating cancer. A multiplicity of functions has been ascribed to PKC. Recurring them...
Published: 7/22/2011   |   Inventor(s): Mahin Maines
Keywords(s): Cancer, Oncology, Peptide, Protein, Target Validation, Therapy
Category(s): Therapeutic
The Use of Rad51 Promoter Constructs in Anticancer Therapy
Applications: This technology provides a potential method for the killing or at least inhibiting cell growth of only cancer cells, by the induction of cytotoxic genes using Rad51 promoter constructs. The Rad51 promoters can also be used as an indicator marker for cancer cells to aid in diagnosis and possible treatments. Advantages: The advantag...
Published: 10/29/2010   |   Inventor(s): Vera Gorbunova, Andrei Seluanov, Christopher Hine
Keywords(s): Cancer, Therapy
Category(s): Therapeutic
Protein Kinase C-Associated Kinase PKK is Required for NF-kB Signaling and Survival in Diffuse Large-B Cell Lymphoma Cells
Applications:This invention provides a novel drug target for the treatment of B-cell lymphoma. NFkB plays an important role in the proliferation and the survival of many types of B lymphoma cells. Inhibition of the novel target will lead to inactivation of transcript factor NFkB in specific cell targets and cause certain types of B lymphoma cells...
Published: 6/17/2009   |   Inventor(s): Luojing Chen, Jiyong Zhao
Keywords(s): Cancer, Cell Signalling, Immunology, Oncology, Therapy
Category(s): Therapeutic
Modulating Melanin Expression
Compounds which can induce melanin expression to aid in certain clinical indications or for cosmetic purposes.Problem Solved by This TechnologyMelanin is important for disease prevention, because it absorbs ultraviolet light in the UVB and UVA spectrum. This protects keratinocytes from the mutagenic effects of sunlight. In addition, melanin has a s...
Published: 6/17/2009   |   Inventor(s): Benjamin Miller, Brian Mcnaughton, Peter Gareiss, Glynis Scott
Keywords(s): Cancer, Dermatology, Oncology, Small Molecule, Therapy
Category(s): Therapeutic
Robot-Assisted Platform for Intratumoral Delivery (RAPID) System
ApplicationsThis technology relates to robot-assisted radioactive seed implantation for prostate brachytherapy. It is an automated system for delivery of seeds or other therapeutic or diagnostic capsules to internal organs of the patient’s body for radiation brachytherapy and includes a needling mechanism, a 2DOF robot, an ultrasound probe dr...
Published: 3/27/2009   |   Inventor(s): Yan Yu, Wan Sing Ng, Yongde Zhang, Tarun Podder
Keywords(s): Cancer, Instrument, Instrumentation, Prostate, Therapy
Category(s): Surgical/Medical Device
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