Search Results - cancer

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Protein Transducing Domain/Deaminase Chimeric Proteins, Related Compounds, and Uses Thereof
Applications:Along with 1174, the present invention is directed to provide a chimeric protein capable of transduction into B cells for purposes of treating Class Switch Recombination and Somatic Hypermutation, both involved in antibody production and diversity, as well as other conditions such as B cell lymphoma.
Published: 4/29/2019   |   Inventor(s): Harold Smith, Mark Sowden, Stephen Dewhurst, Baek Kim, Joseph Wedekind
Keywords(s): Cancer, Gene Therapy, Oncology
Category(s): Therapeutic
Photoacoustic Imaging Using a Versatile Acoustic Lens
Applications:Photoacoustic imaging (also called optoacoustic or thermoacoustic imaging) has the potential to image animal or human organs with simultaneous high contrast and high spatial resolution. The photoacoustic signal is small and needs a mechanism to focus it on an image plane without degradation. This technology improves the signal to noise...
Published: 4/17/2019   |   Inventor(s): Vikram Dogra, Navalgund Rao, Wayne Knox
Keywords(s): Cancer, Diagnostic, Instrument, Instrumentation, Medical Device, Oncology, Prostate, Ultrasound, Ultrasound Imaging
Category(s): Imaging
Novel Melampomagnolide-based Anti-Cancer Drugs and Pro-Drugs that Target Leukemia Stem Cells
Brief Description: Adult acute leukemia is an extremely serious disease, resulting in death for the majority of patients. Despite decades of intensive research, long-term cures are obtained for only approximately 30% of patients. Thus, there is an urgent need for the development of treatment regimens that are more efficacious and less toxic to...
Published: 2/26/2019   |   Inventor(s): Craig Jordan, Shanshan Pei
Keywords(s): Blood, Cancer, Leukemia
Category(s): Therapeutic
A Low Cost Device for the Detection of Prostate Cancer in Real Time
An inexpensive device for early detection of prostate cancer.Problem Solved by This TechnologyCurrent Digital Rectal Exams and chemical screening methods, such as PSA, provide statistically inadequate detection of early prostate cancer development. Moreover, these modalities provide no information relating to the location or the extent of malignancy....
Published: 9/3/2014   |   Inventor(s): Stephen Arnold, Vikram Dogra, Navalgund Rao
Keywords(s): Cancer, Diagnostic, Instrument, Instrumentation, Medical Device, Oncology, Prostate, Ultrasound, Ultrasound Imaging
Category(s): Imaging
New Therapeutic Treatment for Multiple Myeloma and Lymphoma
Brief Description:This invention discloses a new therapeutic method for treating multiple myeloma and lymphoma. Technology Status: In vitro tests have showed that small molecule compounds are effective in suppressing tumor cell growth. New compounds are being identified and tested. In vivo testing in mice has also been planned.
Published: 7/19/2012   |   Inventor(s): Jiyong Zhao
Keywords(s): Cancer, Small Molecule
Category(s): Therapeutic
Biliverdin Reductase (BVR) Peptides That Inhibit PCK-delta for the Potential Treatment of Cancer and Inflammation
Applications: Dr. M. Maines is a leading expert in BVR research and has uncovered many applications for this enzyme. In this invention she has linked BVR to modulation of PKC and found potent inhibitory peptides that may have utility in both understanding and treating cancer. A multiplicity of functions has been ascribed to PKC. Recurring themes...
Published: 7/22/2011   |   Inventor(s): Mahin Maines
Keywords(s): Cancer, Oncology, Peptide, Protein, Target Validation, Therapy
Category(s): Therapeutic
Protein Kinase C-Associated Kinase PKK is Required for NF-kB Signaling and Survival in Diffuse Large-B Cell Lymphoma Cells
Applications:This invention provides a novel drug target for the treatment of B-cell lymphoma. NFkB plays an important role in the proliferation and the survival of many types of B lymphoma cells. Inhibition of the novel target will lead to inactivation of transcript factor NFkB in specific cell targets and cause certain types of B lymphoma cells...
Published: 6/17/2009   |   Inventor(s): Luojing Chen, Jiyong Zhao
Keywords(s): Cancer, Cell Signalling, Immunology, Oncology, Therapy
Category(s): Therapeutic
Modulating Melanin Expression
Compounds which can induce melanin expression to aid in certain clinical indications or for cosmetic purposes.Problem Solved by This TechnologyMelanin is important for disease prevention, because it absorbs ultraviolet light in the UVB and UVA spectrum. This protects keratinocytes from the mutagenic effects of sunlight. In addition, melanin has a social...
Published: 6/17/2009   |   Inventor(s): Benjamin Miller, Brian Mcnaughton, Peter Gareiss, Glynis Scott
Keywords(s): Cancer, Dermatology, Oncology, Small Molecule, Therapy
Category(s): Therapeutic
Robot-Assisted Platform for Intratumoral Delivery (RAPID) System
ApplicationsThis technology relates to robot-assisted radioactive seed implantation for prostate brachytherapy. It is an automated system for delivery of seeds or other therapeutic or diagnostic capsules to internal organs of the patient’s body for radiation brachytherapy and includes a needling mechanism, a 2DOF robot, an ultrasound probe driver,...
Published: 3/27/2009   |   Inventor(s): Yan Yu, Wan Sing Ng, Yongde Zhang, Tarun Podder
Keywords(s): Cancer, Instrument, Instrumentation, Prostate, Therapy
Category(s): Surgical/Medical Device
Photodynamic Therapy with Spatially-Resolved Dual Spectroscopic Monitoring and Related System
Brief Description:Since 2003, a collaborative research effort between researchers at the University of Rochester Medical Center (URMC) and the Roswell Park Cancer Institute (RPCI) has resulted in the development of a system for delivery of photodynamic therapy(PDT) for the treatment of cancer with capabilities for realtime spectroscopic monitoring and...
Published: 3/24/2009   |   Inventor(s): Thomas Foster, William Cottrell, Chad Bigelow, Allan Oseroff
Keywords(s): Cancer, Instrumentation, Laser Systems, Medical Device, Optical Fiber, Therapy
Category(s): Therapeutic