Search Results - neurological

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Novel Serum Markers for the Diagnosis of Concussions and Mild Traumatic Brain Injury (HDL particles size and with combination with S100B)
Applications:This invention offers novel serum markers that can be used to diagnose mild traumatic brain injury (mTBI) in a time- and cost-efficient fashion. Traumatic brain injury (TBI) affects over one million patients each year in the United States. Nearly 90% of these injuries are classified as mTBI or concussion, which leads to subtle cognitive...
Published: 4/29/2019   |   Inventor(s): Bryan Blyth, Jeffrey Bazarian
Keywords(s): Biomarkers, Diagnostic, Neurological
Category(s): Diagnostic
Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System
Applications:Activated protein C (APC), pro-drug, and/or a variant thereof may be used as an inhibitor of apoptosis or cell death and/or a cell survival factor, especially for stressed or injured cells or tissues of the nervous system including subjects with neurodegenerative disorders.Advantages:Novel biological functions (e.g., neuroprotection) can...
Published: 4/29/2019   |   Inventor(s): Berislav Zlokovic, John Griffin
Keywords(s): Aging, Alzheimer's, Neurological, Therapy
Category(s): Therapeutic
Identification of a Novel Stem Cell Marker
Applications:The invention identifies a Novel Stem Cell Marker Gpr177, a G Protein-coupled Receptor. Gpr177 is a useful marker in the identification, isolation and characterization of specific stem cell population, including neural stem cells in specific regions of the brain and spinal cord, and cancer stem cells as well.Advantages:The Gpr177-expressing...
Published: 6/17/2009   |   Inventor(s): Wei Hsu
Keywords(s): Biomarkers, Neurological, Research Tool, Stem Cell
Category(s): Research Tools
Transgenic Mouse Model of Parkinson's Disease Containing Either Wild-Type or Doubly-Mutated Human Alpha-synuclein
ApplicationsThis transgenic mouse model can be used to study Parkinson's Disease. The mouse model expresses a doubly mutated form of human alpha-synuclein. AdvantagesThis model has proven useful in understanding the pathogenesis of Parkinson's disease in humans and can be useful in designing rational interventions to slow or halt the course of the...
Published: 6/17/2009   |   Inventor(s): Howard Federoff, Eric Richfield
Keywords(s): Mouse, Neurological, Research Tool
Category(s): Research Tools