Search Results - research tool

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Inducing Immune Responses Using Platelets
Brief Description: The use of patients own dendritic cells pulsed with a specific antigen to induce T-cells responses and induction of memory T-cells is widely known as an approach for stimulating the immune system in individualized medicine. This approach entails isolation of monocytes from the blood (where their numbers are relatively low) ...
Published: 10/12/2012   |   Inventor(s): Craig Morrell
Keywords(s): Antibacterial, Antiviral, Cancer, Infection, Infectious Disease, Research Tool
Category(s): Vaccines, Therapeutic
RNA Modification to Modulate Telomerase Activity
Applications:2’-O-methylation at U809 reduces telomerase activity resulting in telomere shortening, whereas 2’-O-methylation at A804 or A805 leads to moderate telomere lengthening.Advantages:Researchers at the University of Rochester have shown that the use of 2’-O-methylation can be accomplished in vivo and have an effect on telo...
Published: 8/1/2011   |   Inventor(s): Yi-Tao Yu, Chao Huang
Keywords(s): Cancer, Research Tool, RNA
Category(s): Therapeutic
Mice Carrying Null or Conditional Mutations in the Bambi Gene
Applications:The Bambi gene encodes an inhibitory pseudoreceptor for the Bmp/TGF-beta super-family of signaling molecules. The Bambi mutant mice will be useful for research and drug development for cardiovascular and musculoskeletal diseases, stem cell biology and cancer biology, liver function and homeostasis, immune system modulation, etc.Advanta...
Published: 6/17/2009   |   Inventor(s): Rulang Jiang, Jianquan Chen, Jeffrey Bush
Keywords(s): Mouse, Research Tool
Category(s): Research Tools
Human KC-NL Crosstalk Subversion by HCV
Applications:The invention has developed an in vitro culture system based on the isolation of human Kupffer cells (KC) and natural Killer Cells (NK) from the donated liver grafts. The model can be used for the identification of drug targets of viral hepatitis, and for testing drugs and biologics.Advantages:The model uses human cells directly from t...
Published: 6/17/2009   |   Inventor(s): Mark Orloff, Ian Nicholas Crispe
Keywords(s): Cell Signalling, Immunology, Research Tool, Therapy
Category(s): Research Tools
Identification of a Novel Stem Cell Marker
Applications:The invention identifies a Novel Stem Cell Marker Gpr177, a G Protein-coupled Receptor. Gpr177 is a useful marker in the identification, isolation and characterization of specific stem cell population, including neural stem cells in specific regions of the brain and spinal cord, and cancer stem cells as well.Advantages:The Gpr177-expre...
Published: 6/17/2009   |   Inventor(s): Wei Hsu
Keywords(s): Biomarkers, Neurological, Research Tool, Stem Cell
Category(s): Research Tools
Mouse Model of Chronic Viral Hepatitis
Applications:The invention generates a novel mouse model of acute and chronic T cell mediated hepatitis, which shares some important features with viral hepatitis in man. The mouse model is valuable in identifying drug targets for viral hepatitis.Advantages:The mouse model is driven directly by CD8+ T cell and results from the recognition of an ant...
Published: 6/17/2009   |   Inventor(s): Ian Nicholas Crispe, Robert Pierce
Keywords(s): Gastrointestinal, Hepatic, Mouse, Research Tool, Viral disease
Category(s): Research Tools
Carbohydrate-targeted Therapeutic Agents, Diagnostics, and Sensors
Applications:Carbohydrates represent a particularly enticing and important challenge to the organic chemist interested in molecular recognition. In addition to their role in addressing the fundamental problem of understanding binding and selectivity, novel carbohydrate receptors have significant potential as tools in the rapidly evolving field of g...
Published: 6/17/2009   |   Inventor(s): Benjamin Miller, Prakash Palde, Peter Gareiss
Keywords(s): Research Tool
Category(s): Research Tools
Antigen Release Beads for a Quantitative ELISPOT or FLORISPOT Assay
Applications:This research has developed a method to quantify the specific amount of antigen released by cells in an ELISPOT assay.Advantages:Currently, an ELISPOT assay can only quantify the number of cells producing a particular antigen. This technology allows the user to create a standard curve for antigen release and determine the actual amount...
Published: 6/17/2009   |   Inventor(s): Martin Zand, Alicia Henn, Miguel Brown
Keywords(s): Research Tool
Category(s): Research Tools
Kcnn4 Knockout Mouse
Applications:The Kcnn4 Knockout Mouse model will be helpful for developing treatment for sickle cell anemia and diarrhea.Advantages:Kcnn4 Knockout Mouse model can be used for testing function, related genetic diseases and treatment related to the Kcnn4 gene.
Published: 6/17/2009   |   Inventor(s): James Melvin, Catherine Ovitt, Keith Nehrke, Ted Begenisich
Keywords(s): Research Tool
Category(s): Research Tools
A Model to Study the Role of IL-1ß in Neurodegeneration and Brain Injury
Applications:A novel transgenic mouse model was created to investigate the role of IL1ß in neurodegeneration and brain injury. This model may also be used to test existing and novel drugs and therapies for suppression of neuroinflammation associated with brain disorders.Advantages:Creation of conditionally expressed IL1ß and IL-1A (rece...
Published: 6/17/2009   |   Inventor(s): M. Kerry O'banion, Stephanos Kyrkanides
Keywords(s): Alzheimer's, Research Tool
Category(s): Research Tools
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