Search Results - oncology

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Protease Activated Cytokines as Anti-Cancer Therapy

A novel therapy method for delivering localized anti-cancer responses without adverse body-wide side effects. Problem Solved by the Technology Despite remarkable success at identifying tumor-associated antigens (TAA), generating effective anti-tumor immune response has not been successful at eliminating tumors. Systemically administered active drugs...

Published: 9/19/2023 | Inventor(s): John Frelinger, John Puskas, Baek Kim, Mark Sullivan

Keywords(s): Cancer, Immunotherapy, Oncology, Therapy

Category(s): Therapeutic

Protein Transducing Domain/Deaminase Chimeric Proteins, Related Compounds, and Uses Thereof

Applications:Along with 1174, the present invention is directed to provide a chimeric protein capable of transduction into B cells for purposes of treating Class Switch Recombination and Somatic Hypermutation, both involved in antibody production and diversity, as well as other conditions such as B cell lymphoma.

Published: 10/5/2023 | Inventor(s): Harold Smith, Mark Sowden, Stephen Dewhurst, Baek Kim, Joseph Wedekind

Keywords(s): Cancer, Gene Therapy, Oncology

Category(s): Therapeutic

Photoacoustic Imaging Using a Versatile Acoustic Lens

Applications:Photoacoustic imaging (also called optoacoustic or thermoacoustic imaging) has the potential to image animal or human organs with simultaneous high contrast and high spatial resolution. The photoacoustic signal is small and needs a mechanism to focus it on an image plane without degradation. This technology improves the signal to noise...

Published: 10/5/2023 | Inventor(s): Vikram Dogra, Navalgund Rao, Wayne Knox

Keywords(s): Cancer, Diagnostic, Instrument, Instrumentation, Medical Device, Oncology, Prostate, Ultrasound, Ultrasound Imaging

Category(s): Imaging

Biliverdin Reductase (BVR) Peptides That Inhibit PCK-delta for the Potential Treatment of Cancer and Inflammation

Applications: Dr. M. Maines is a leading expert in BVR research and has uncovered many applications for this enzyme. In this invention she has linked BVR to modulation of PKC and found potent inhibitory peptides that may have utility in both understanding and treating cancer. A multiplicity of functions has been ascribed to PKC. Recurring...

Published: 5/23/2023 | Inventor(s): Mahin Maines

Keywords(s): Cancer, Oncology, Peptide, Protein, Target Validation, Therapy

Category(s): Therapeutic

Modulating Melanin Expression

Compounds which can induce melanin expression to aid in certain clinical indications or for cosmetic purposes.Problem Solved by This TechnologyMelanin is important for disease prevention, because it absorbs ultraviolet light in the UVB and UVA spectrum. This protects keratinocytes from the mutagenic effects of sunlight. In addition, melanin has a social...

Published: 2/14/2024 | Inventor(s): Benjamin Miller, Brian Mcnaughton, Peter Gareiss, Glynis Scott

Keywords(s): Cancer, Dermatology, Oncology, Small Molecule, Therapy

Category(s): Therapeutic