Latest technologies from University of Rochesterhttp://rochester.technologypublisher.comBe the first to know about the latest inventions and technologies available from University of Rochesteren-USThu, 22 Mar 2018 08:25:43 GMTMon, 06 Nov 2017 10:48:01 GMT 2018, University of RochesterDirect Patterning of OLED RGB Color Emitter Layers for High-Brightness High-Resolution Microdisplays methods to produce color emitter layers use a metal shadow mask which suffers from resolution issues and therefore prevents color emitter sub-pixel sizes under 10 microns. Consequently, high resolution OLED microdisplay RGB sub-pixels are typically formed by using white OLED with an overlaying color filter to produce the RBG sub-pixels. The color filters themselves absorb approximately 80% of the white light and therefore reduce the light output from the OLED. By using direct patterning of OLED with stencil lithography we can enable high efficiency high-resolution OLED microdisplays. T...Mon, 06 Nov 2017 10:48:01 GMTdavid_englert@urmc.rochester.edu Novel Diagnostic Test for Bacterial vs Viral Respiratory Infections, 30 Aug 2017 11:10:24 GMTdavid_englert@urmc.rochester.edu Equine Flu Vaccine, 09 Aug 2017 10:15:35 GMTdavid_englert@urmc.rochester.edu Sonoelastographic Imaging by Crawling Wave, 08 Aug 2017 11:42:36 GMTdavid_englert@urmc.rochester.edu Imaging of Soft Tissue, 08 Aug 2017 11:42:34 GMTdavid_englert@urmc.rochester.edu Molecule Anti-Scarring Agents, 01 May 2017 12:43:02 GMTdavid_englert@urmc.rochester.edu'-oxime Promotes Human Mesenchymal Stem Cell Proliferation, Stem Cell Phenotype, and Population Homogeneity, 16 Mar 2017 11:53:03 GMTdavid_englert@urmc.rochester.edu Detection of and Treatment for Neurodegenerative Diseases, 20 Oct 2016 13:42:04 GMTdavid_englert@urmc.rochester.edu Live Attenuated Flu Vaccine, 13 Oct 2016 13:32:07 GMTdavid_englert@urmc.rochester.edu against Pneumocystis and Streptococcal Infections, 21 Sep 2016 11:46:47 GMTdavid_englert@urmc.rochester.edu against Pneumocystis and Streptococcal Infections, 21 Sep 2016 11:46:46 GMTdavid_englert@urmc.rochester.edu Drug/Vaccine Delivery System novel peptide-based strategy for controlled transepithelial delivery of therapeutic molecules. Problem Solved by this TechnolgyTransdermal drug delivery systems (TDDS) are increasingly becoming an attractive alternative to the oral route as this method can avoid first pass effects, can provide steady drug plasma levels and is poised to replace painful hypodermic injections. Intact skin acts as a natural barrier and can impede transdermal delivery of therapeutic agents. Existing TDDS deliver only small molecule drugs and cannot be used for larger therapeutic agents such as antibodies and vacc...Thu, 01 Sep 2016 05:48:37 GMTdavid_englert@urmc.rochester.edu Novel Approach to Treatment of Hyperglycemia Using a Nano-Particle-Encapsulated Peptide, 21 Jul 2016 11:15:42 GMTdavid_englert@urmc.rochester.edu Charcot-Marie-Tooth Disease Health Index (CMT-HI) The CMT-Health Index (CMT-HI) is a disease-specific, patient-reported, outcome measure designed to reliably and responsively measure therapeutic benefit in Charcot-Marie-Tooth disease (CMT) clinical trials. The CMT-HI may also be used to measure overall patient health in a clinical setting. It covers the 18 areas of greatest importance to the adult CMT population and has been designed to satisfy recommendations from the FDA for use in drug labeling claims. Applications The CMT-HI is capable of both classifying patients with inherited neuropathies and measuring clinically-relevant change in di...Thu, 30 Jun 2016 13:09:09 GMTdavid_englert@urmc.rochester.edu Myotonic Dystrophy Health Index (MDHI) Italian Version The Myotonic Dystrophy Health Index (MDHI) Italian Version is a survey designed to efficiently measure the overall level of disease burden in a patient with myotonic dystrophy type-1 whose native language is Italian. This disease-specific patient-reported outcome measure is designed is designed to reliably and responsively measure therapeutic benefit in myotonic dystrophy clinical trials. It may also be used to measure overall patient health in a clinical setting. It covers the 17 areas of greatest importance to the adult myotonic dystrophy population. The MDHI is a disease-specific, patient ...Thu, 30 Jun 2016 13:09:09 GMTdavid_englert@urmc.rochester.edu Myotonic Dystrophy Health Index Short Form (MDHI-SF), 30 Jun 2016 13:09:08 GMTdavid_englert@urmc.rochester.edu and Childhood Myotonic Dystrophy Research Survey: Instrument for Children Ages 5 to 7, 30 Jun 2016 13:08:54 GMTdavid_englert@urmc.rochester.edu and Childhood Myotonic Dystrophy Health Index: Instrument for Children Ages 8 to 11, 30 Jun 2016 13:08:53 GMTdavid_englert@urmc.rochester.edu and Childhood Myotonic Dystrophy Health Index: Instrument for Children Ages 12 to 17, 30 Jun 2016 13:08:52 GMTdavid_englert@urmc.rochester.edu and Childhood Myotonic Dystrophy Health Index: Parent Proxy Instrument, 30 Jun 2016 13:08:51 GMTdavid_englert@urmc.rochester.edu Therapy for Inflammatory Bowel and Celiac Diseases, 06 Jun 2016 07:59:20 GMTdavid_englert@urmc.rochester.edu Rochester Digital Cloak, 19 May 2016 07:33:11 GMTdavid_englert@urmc.rochester.edu for Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis via Detecting and Inhibiting Histone Methylation and Associated Proteins, 18 May 2016 11:18:25 GMTdavid_englert@urmc.rochester.edu for Female Infertility A novel treatment for a variety of conditions resulting in female infertility. Problem Solved by this Technology Anti-Müllerian hormone (AMH) acts as a natural follicular gatekeeper limiting follicle growth initiation and maintains the primordial follicle pool during reproductive years. AMH is also an intra-ovarian regulator that inhibits follicular atresia at later stages of follicle development. Thus, low AMH levels lead to more rapid follicle loss contributing to pathophysiological conditions called diminished ovarian reserve (DOR) and premature ovarian failure (also known as premature ova...Tue, 12 Apr 2016 11:43:38 GMTdavid_englert@urmc.rochester.edu, Plentiful, and Environmentally Friendly Method for Producing Hydrogen, 12 Apr 2016 11:29:13 GMTdavid_englert@urmc.rochester.edu of High Molecular Weight Hyaluronic Acid, 02 Jul 2015 11:04:41 GMTdavid_englert@urmc.rochester.edu to Determine the Location of the Guidewire in Lumpectomy Excisions, 28 Apr 2015 13:44:30 GMTdavid_englert@urmc.rochester.edu Safer Nasal Spray Flu Vaccines, 26 Mar 2015 12:43:50 GMTdavid_englert@urmc.rochester.edu of Arenavirus Vaccines through Codon Deoptimization A novel strategy for developing live-attenuated arenavirus vaccines. Problem Solved by the TechnologyArenaviruses have a significant impact on public health and pose a credible threat to biodefense.There are four arenaviruses that cause severe hemorrhagic fever in humans (Lassa virus, endemic to Africa; and Machupo, Junin, and Guanarito viruses endemic to South America). A fifth arenavirus, lymphocytic choriomeningitis virus (LCMV), is found throughout the world and it is particularly troublesome for immunocompromised individuals. Safe and effective arenavirus vaccines have remained elusiv...Tue, 24 Mar 2015 14:07:15 GMTdavid_englert@urmc.rochester.edu Planning Document To Facilitate Correlation of IVUS and CT Scan Measurements For Placement Of IVUS-Guided IVC Filters Preoperative planning document for the single puncture intravasular ultrasound (IVUS) guided bedside placement of IVC filters. Application Pulmonary Embolism (PE) has been reported in over 350,000 patients per year, with an estimated annual mortality rate of 240,000. Vena cava filtration is being used as an effective means of prophylaxis against PE in post-operative and critically ill patients. A safe and cost-effective method of placing the filters is through single puncture intravasular ultrasound (IVUS) guided bedside placement which eliminates risk of patient transport and exposure to int...Mon, 09 Mar 2015 08:51:04 GMTdavid_englert@urmc.rochester.edu Depth Advancement Marker Needle for Image Guided Injections (DAMNIGI), 09 Mar 2015 08:51:02 GMTdavid_englert@urmc.rochester.edu Non-Contact ECG System Employing Artifact Compensation, 09 Mar 2015 08:50:59 GMTdavid_englert@urmc.rochester.edu of Regularly Shaped Polymer Cholesteric Liquid Crystal Flakes with a Mechanically Flexible Mold This invention relates to manufacturing micron-sized shaped flakes of plastic (flowable) material which have precise configurations, and particularly to making flakes of polymeric liquid crystal materials to be used in a host fluid in electrically addressable optical devices for information displays. Advantages: Micron sized PCLC flakes that are more regularly shaped behave with more uniform motion within an electro-optic cell. Current freeze fracture methods used to manufacture polymer cholestric liquid crystal flakes result in arbitrary shapes. This invention, however, uses m...Wed, 07 Jan 2015 10:20:31 GMTdavid_englert@urmc.rochester.edu Endotracheal Tube (ET) Securement, 10 Dec 2014 08:44:23 GMTdavid_englert@urmc.rochester.edu Mix and Inject Prefillable Syringe System, 20 Nov 2014 07:55:23 GMTdavid_englert@urmc.rochester.edu Paraxial Cloak Design and Device, 01 Oct 2014 09:07:15 GMTdavid_englert@urmc.rochester.edu Shape Memory Polymers, 03 Sep 2014 07:48:15 GMTdavid_englert@urmc.rochester.edu Low Cost Device for the Detection of Prostate Cancer in Real Time, 03 Sep 2014 07:45:22 GMTdavid_englert@urmc.rochester.edu for Hyperammonemic Encephalopathy and Seizures, 07 Aug 2014 13:02:16 GMTdavid_englert@urmc.rochester.edu Small Molecules to Treat Alzheimer’s Disease, 05 Aug 2014 07:25:25 GMTdavid_englert@urmc.rochester.edu Atom Labeled acyl-CoA A novel protocol to produce large quantities of nearly 100% homogenous heavy-labeled acyl-CoAs rapidly and inexpensively. Problem Solved by this Technology Individual heavy atom-labeled acyl-CoAs are currently available made-to-order through several companies or are being generated in-house in labs as needed. The production of a full battery of acyl-CoAs is currently achieved using mammalian cells in a tedious and expensive process (that requires ~10 weeks and thousands of dollars in reagents). Researchers at the University of Rochester and the University of Pennsylvania have developed an alt...Mon, 04 Aug 2014 10:48:00 GMTdavid_englert@urmc.rochester.edu Activated Cytokines as Anti-Cancer Therapy, 21 Jul 2014 13:08:59 GMTdavid_englert@urmc.rochester.edu Method to Prevent or Treat Fibrosis A novel method for treating and preventing fibrosis and fibrosis-related conditions using fibronectin binding proteins and polypeptides. Problem Solved by the Technology Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue that can alter the architecture and compromise the function of that organ or tissue. Fibrosis usually occurs as a result of injury and inflammation, and can present itself in different tissues. Examples include lungs (pulmonary fibrosis, idiopathic pulmonary fibrosis, cystic fibrosis), liver (including cirrhosis), heart (myocardial fibrosis...Thu, 17 Jul 2014 11:27:57 GMTdavid_englert@urmc.rochester.edu Self-Renewing Erythroblasts (ESRE) This technology provides a human cell population that can self-renew extensively and yet retain the capacity to differentiate into red blood cells (RBCs). These cells are referred to as extensively self-renewing erythroblasts (ESREs). The ESREs can serve as a renewable source of transfusable RBCs. URV Reference Number: 6-2201Mon, 19 May 2014 12:29:13 GMTdavid_englert@urmc.rochester.edu Synthetic Lung Surfactant Peptides A novel synthetic lung surfactant for the treatment of neonatal and acute respiratory distress syndromes. Problem Solved by the TechnologyLung surfactant replacement therapy is commonly used on premature infants with neonatal respiratory distress syndrome (NRDS). NRDS, caused by a lack of surfactant, occurs in 10% of premature babies (1% of all newborns) and is the leading cause of death in premature babies. Research has shown that surfactant therapy can also help to reverse surfactant dysfunction in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). ALI and...Fri, 16 May 2014 13:16:08 GMTdavid_englert@urmc.rochester.edu Preventative Anti-caries and Periodontal Diseases Treatment, 09 May 2014 12:53:34 GMTdavid_englert@urmc.rochester.edu Method of Remyelinating Congenitally Dysmyelinated Forebrains, 17 Apr 2014 12:51:35 GMTdavid_englert@urmc.rochester.edu Therapeutics for Diseases Caused by Nonsense Mutations, 10 Apr 2014 07:28:09 GMTdavid_englert@urmc.rochester.edu Peptidomimetics for Alpha-Helix Mimicry, 09 Apr 2014 11:15:19 GMTdavid_englert@urmc.rochester.edu and Compositions for Ribosomal Synthesis of Macrocyclic Peptides, 09 Apr 2014 11:15:13 GMTdavid_englert@urmc.rochester.edu and Compositions for the Preparation of Conformationally Constrained Peptide-Containing Molecules, 09 Apr 2014 11:14:56 GMTdavid_englert@urmc.rochester.edu for Identifying, Diagnosing, and Predicting Survival of Lymphomas present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information is useful in developing the appropriate therapeutic ap...Wed, 09 Apr 2014 11:14:51 GMTdavid_englert@urmc.rochester.edu Predictor For Diffuse Large B Cell Lymphoma This invention provides methods and arrays related to a gene expression-based survival predictor for DLBCL patients, including patients treated with the current standard of care, which includes chemotherapy and the administration of Rituximab. The invention provides a method of predicting the survival outcome of a subject suffering from diffuse large B cell lymphoma (DLBCL) that includes obtaining a gene expression profile from one or more DLBCL biopsy samples from the subject. The gene expression profile, which can be derived from gene expression product isolated from the one or more biopsy ...Wed, 09 Apr 2014 11:14:51 GMTdavid_englert@urmc.rochester.edu Vaccine Against Type 1 Diabetes A novel vaccine to protect against type 1 diabetes. Problem Solved by the Technology Type 1 diabetes (once known as "juvenile diabetes") is usually detected in children and young adults. It occurs when the pancreas stops producing insulin, the body?s mechanism for converting starch and glucose into energy. This condition is serious and requires continuous monitoring and a life-long regimen of proper diet, exercise, and insulin injections. This course of treatment is difficult to comply with, and carries with it major adverse side-effects. Current immunomodulatory clinical trials failed to a...Thu, 27 Feb 2014 08:41:25 GMTdavid_englert@urmc.rochester.edu Mimics of Discontinuous HIV-1 Envelope Epitopes Recognized by Broadly Neutralizing Antibodies, 15 Nov 2013 09:34:10 GMTdavid_englert@urmc.rochester.edu Fascioscapulohumeral Muscular Dystrophy Health Index (FSHDI) The Fascioscapulohumeral Muscular Dystrophy Health Index (FSHDI) is a disease-specific, patient reported outcome measure for FSHDI. Each question in the FSHDI was selected based on its relevance to a large muscular dystrophy population, its ability to be consistently understood by patients, its reliability during test-retest evaluation, its content validity, its face validity, its construct validity, and its responsiveness in detecting therapeutic change. FDA guidelines were implemented during instrument development in order to allow the FSHDI to be utilized to support drug labeling claims. T...Wed, 09 Oct 2013 06:39:08 GMTdavid_englert@urmc.rochester.edu Derivatives, Methods for Their Preparation and Their Use as Anticancer Agents, 27 Aug 2013 07:03:07 GMTdavid_englert@urmc.rochester.edu Derivatives, Methods For Their Preparation And Their Use As Antimalarial Agents, 27 Aug 2013 07:03:03 GMTdavid_englert@urmc.rochester.edu and Reagents for Site-Specific Labeling of Peptides and Proteins Brief Description: Methods for site-specific protein functionalization find a broad range of applications in the context of protein detection, imaging, and purification, in the development of improved protein-based therapeutics (e.g. via PEGylation), and in the preparation of protein microarrays. This invention describes a new chemical method for site-specifically labeling a target protein at its C-terminus with an organic molecule of interest, such as a fluorescent dye, an affinity tag, a polymer, a drug molecule, etc. This methodology involves the use of novel reagents that can eff...Tue, 27 Aug 2013 07:03:01 GMTdavid_englert@urmc.rochester.edu and Systems for Predicting the Reactivity of Mono-Oxygenase Enzymes Applications This technology provides methods for rapidly finding selective and highly active P450-based oxidation catalysts for the oxyfunctionalization (i.e. hydroxylation, epoxidation) of a target organic molecule. This method is particularly useful for developing synthetic procedures that enable the functional elaboration of a high-value compound (e.g. natural product, lead compound, drug molecule) at poorly reactive or unreactive C?H sites. Accordingly, these methods can be useful in drug discovery and development campaigns toward obtaining analogs of a molecule of interest that possess ...Tue, 27 Aug 2013 07:02:59 GMTdavid_englert@urmc.rochester.edu Super-Resolution Ultrasound Imaging, 21 Jun 2013 05:55:01 GMTdavid_englert@urmc.rochester.edu Time Blood Pressure Monitor and Aneurism Monitor, 07 Jun 2013 07:02:35 GMTdavid_englert@urmc.rochester.edu Interdisciplinary Team Performance in a Long-Term Care Setting description: Theory-based, reliable, and valid measures of interdisciplinary teamwork have long been considered desirable and useful in explaining patient outcomes and in assisting with quality-of-care improvement efforts. This technology is a survey tool used to assess interdisciplinary team performance in a long-term care setting and to measure team performance in the Program of All-Inclusive Care for the Elderly (PACE). Tue, 30 Apr 2013 12:28:59 GMTdavid_englert@urmc.rochester.edu Myotonic Dystrophy Health Index (MDHI), 22 Mar 2013 12:59:14 GMTdavid_englert@urmc.rochester.edu and Purifying Neuronal Stem Cells for Enrichment and Therapeutic Applications, 12 Mar 2013 08:12:39 GMTdavid_englert@urmc.rochester.edu Microfluidic Bubble Bioreactor for Cell Capture, 05 Mar 2013 07:42:47 GMTdavid_englert@urmc.rochester.edu Promotion and Disease Prevention: Action for Health Brief Description: The technology disclosed herein is an online tutorial and course designed for health promotion and disease prevention.Tue, 05 Mar 2013 07:42:44 GMTdavid_englert@urmc.rochester.edu (Academic Graphic Education System), 01 Mar 2013 08:52:32 GMTdavid_englert@urmc.rochester.edu Quick Reference Guide, 01 Mar 2013 08:52:30 GMTdavid_englert@urmc.rochester.edu Metal Surfaces for DNA Microarrays, 01 Mar 2013 08:52:14 GMTdavid_englert@urmc.rochester.edu Brain Magnetic Stimulator, 29 Nov 2012 09:00:57 GMTdavid_englert@urmc.rochester.edu Closure Device (VCD) for Closing Arterial and Venous Access Sites from Procedures Using Sheaths 10 French or Greater, 12 Oct 2012 11:49:22 GMTdavid_englert@urmc.rochester.edu Immune Responses Using Platelets Brief Description: The use of patients own dendritic cells pulsed with a specific antigen to induce T-cells responses and induction of memory T-cells is widely known as an approach for stimulating the immune system in individualized medicine. This approach entails isolation of monocytes from the blood (where their numbers are relatively low) and their differentiation into dendritic cells over many days in cell culture. Therefore, this process is labor intensive, requires large blood volumes and makes contamination a potential major problem limiting the use of this approach as com...Fri, 12 Oct 2012 11:49:17 GMTdavid_englert@urmc.rochester.edu Treatment for Hydrocephalus Brief Description: Ventricular cerebrospinal fluid (CSF) shunting remains the most prominent treatment of choice. CSF shunting procedures provide a rapid means to normalize intracranial pressure and can prevent brain damage. In the U.S. there are approximately 69,000 annual hospital admissions for hydrocephalus resulting in over 40,000 shunting procedures and costing over one billion dollars. The excessive costs predominantly arise from relatively high complication and revision rates as well as costly equipment. This novel device and technique help avoid complications and associat...Tue, 25 Sep 2012 13:01:05 GMTdavid_englert@urmc.rochester.edu Analysis of Cancer Stem Cells in vitro, 25 Sep 2012 13:00:51 GMTdavid_englert@urmc.rochester.edu Matrix Mimetics, 25 Sep 2012 13:00:32 GMTdavid_englert@urmc.rochester.edu Vascularized Tissues using Ultrasound Standing Wave Fields Novel ultrasound-based technologies to pattern human cells and engineer three-dimensional blood vessel networks. Problem Solved by this Technology Current in vitro and animal models for novel drug discovery and testing often do not accurately predict the efficacy or side effects experienced in human trials. Consequently, billions of dollars are spent establishing clinical trials that are doomed to fail. Inexpensive, three-dimensional (3D), vascularized human tissue models have the potential to accurately predict cytotoxicity and pharmacokinetics of new drugs. Additionally, vascularized tissue...Tue, 25 Sep 2012 13:00:23 GMTdavid_englert@urmc.rochester.edu Real-Time Monitor for Strokes and Post Traumatic Brain Injury Complications Brief Description: Real-time monitoring for strokes and post traumatic brain injury complications would provide early warning for timely intervention. Current methods of CT angiography or the use of the Licox probe are impractical for continuous monitoring, especially in moving subjects. Applications: This invention relates to an implantable device for continuous monitoring of post-stroke patients to prevent recurrent strokes. It would also allow monitoring for any complications following traumatic brain injury. Treatment for stroke is more time sensitive but less dramatic on pr...Thu, 19 Jul 2012 08:26:28 GMTdavid_englert@urmc.rochester.edu of Studying Human and Non-Human Epidermal, 19 Jul 2012 08:26:25 GMTdavid_englert@urmc.rochester.edu NDSR Analysis Comparison Tool (SNAC), 19 Jul 2012 08:26:22 GMTdavid_englert@urmc.rochester.edu Therapeutic Treatment for Multiple Myeloma and Lymphoma, 19 Jul 2012 08:26:21 GMTdavid_englert@urmc.rochester.edu Support Bracket, 19 Jul 2012 08:26:20 GMTdavid_englert@urmc.rochester.edu Multi-criteria Decision Support Framework, 19 Jul 2012 08:26:18 GMTdavid_englert@urmc.rochester.edu Information Forms for FSHD (Facioscapulohumeral Muscular Dystrophy), DM (Myotonic Dystrophy), and Unaffected Blood Relatives of Individuals with FSHD or DM, 19 Jul 2012 08:26:16 GMTdavid_englert@urmc.rochester.edu For Determining The Presence Or Risk Of Developing Facioscapulohumeral Dystrophy (FSHD), 19 Jul 2012 08:26:15 GMTdavid_englert@urmc.rochester.edu Checklists for FSHD (Facioscapulohumeral Muscular Dystrophy) and DM (Myotonic Dystrophy), 19 Jul 2012 08:26:13 GMTdavid_englert@urmc.rochester.edu Testing Model, 19 Jul 2012 08:26:12 GMTdavid_englert@urmc.rochester.edu Procedures Operations Manual, 19 Jul 2012 08:26:11 GMTdavid_englert@urmc.rochester.edu - Immune Profiling Visualization Software, 19 Jul 2012 08:26:07 GMTdavid_englert@urmc.rochester.edu 2.0, 19 Jul 2012 08:26:06 GMTdavid_englert@urmc.rochester.edu This invention is software that enhances the usability of Lucid Inc. for the purpose of using their Vivascope devices for assessment of Meissner Corpuscle density as a measure of sensory neuropathies. Applications: This software has significantly enabled quantization of Meissner Corpuscles by markedly decreasing the time required for assembly of images for Meissner corpuscles analysis and also by simplifying and semi-automating counts and morphologic and morphometric assessments of Meissner Corpuscles. This software will enable Meissner corpuscle density assessment as a measure of various s...Thu, 19 Jul 2012 08:26:02 GMTdavid_englert@urmc.rochester.edu Facts, 19 Jul 2012 08:26:00 GMTdavid_englert@urmc.rochester.edu to Toxicology, 19 Jul 2012 08:25:50 GMTdavid_englert@urmc.rochester.edu Model of the Brain, 19 Jul 2012 08:25:49 GMTdavid_englert@urmc.rochester.edu DNA Probes for the Diagnosis of Methicillin-Resistance in Staphylococcus Aureus, 19 Jul 2012 08:25:16 GMTdavid_englert@urmc.rochester.edu Vision Equation for Enhanced Zyoptix Outcome, 19 Jul 2012 08:25:12 GMTdavid_englert@urmc.rochester.edu mRNA Decay Pathway to Regulate Gene Expression, 02 Mar 2012 10:43:18 GMTdavid_englert@urmc.rochester.edu Productivity Program, 13 Feb 2012 13:03:53 GMTdavid_englert@urmc.rochester.edu to Document and Manage Core Measure Conditions, 12 Oct 2011 13:14:28 GMTdavid_englert@urmc.rochester.edu Microfluidic Bubble Bioreactor for Cell Capture, 28 Sep 2011 07:38:25 GMTdavid_englert@urmc.rochester.edu Modification to Modulate Telomerase Activity, 01 Aug 2011 11:33:28 GMTdavid_englert@urmc.rochester.edu Therapy Using a Combined Drugs Protocol Many immunocompromised patients suffer from pulmonary and central nervous system fungal infections caused by pathogens such as C. neoformans. The current standard treatment entails intravenously administrating anti-fungal agents that are extremely toxic. In addition, new structural and mechanistic classes of antifungal therapeutics are needed to improve treatment options and to counter increasing resistance to currently used agents. This invention identifies and validates a novel treatment regime entailing a combination of two drugs. Applications: Dr. Damian Krysan of the URMC has fo...Mon, 01 Aug 2011 11:33:27 GMTdavid_englert@urmc.rochester.edu Reductase (BVR) Peptides That Inhibit PCK-delta for the Potential Treatment of Cancer and Inflammation Applications: Dr. M. Maines is a leading expert in BVR research and has uncovered many applications for this enzyme. In this invention she has linked BVR to modulation of PKC and found potent inhibitory peptides that may have utility in both understanding and treating cancer. A multiplicity of functions has been ascribed to PKC. Recurring themes are that PKC is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory. These functions are achieved by ...Fri, 22 Jul 2011 13:46:31 GMTdavid_englert@urmc.rochester.edu of Interest (COI) Description: A web-based tool to assess and mitigate conflict of interest in collected and reported data. Applications: Conflict of Interest (COI) is a secured, internal, web-based tool designed to allow the manipulation, collection and management of any reported data that may potentially be considered a conflict of interest. The logic built-in can be altered for collection based questions. The technology is built around a three layer architecture that includes an interface, database, and business logic layer. Thu, 26 May 2011 12:03:40 GMTdavid_englert@urmc.rochester.edu Abuse Scale (TAS), 26 May 2011 12:03:39 GMTdavid_englert@urmc.rochester.edu, Accurate, Real-Time 3D Imaging System, 26 May 2011 12:03:35 GMTdavid_englert@urmc.rochester.edu Novel Approach to S.mutans Diagnostics, Therapeutic Intervention and Vaccines Brief Description: Streptococcus mutans (S.mutans) is a major pathogen commonly found in the human oral cavity and is associated with dental caries. Dissemination of oral bacteria into the bloodstream is very common in patients subjected to dental procedures. S.mutans, if presents in the bloodstream, is suspected as a leading causative agent of cardiovascular diseases (CVD) such as infective endocarditis (IE), a life-threatening inflammation of the heart valves. Recently it has been shown that S. mutans is the most prevalent bacterial species in heart vegetations and atheromatous pl...Thu, 26 May 2011 12:03:23 GMTdavid_englert@urmc.rochester.edu of the Week for Medical Providers, 26 May 2011 12:03:11 GMTdavid_englert@urmc.rochester.edu and Systems for Vertigo Treatment, 15 Apr 2011 07:01:36 GMTdavid_englert@urmc.rochester.edu Forms for: Cellular and Molecular Pathophysiology (CAMP) of Facioscapulohumeral Muscular Dystrophy (FSHD) Study, 15 Apr 2011 07:01:35 GMTdavid_englert@urmc.rochester.edu Procedure Load Index (PLI), 28 Feb 2011 08:34:35 GMTdavid_englert@urmc.rochester.edu the Ocular Point Spread Function Using Adaptive Optics, 28 Feb 2011 08:34:29 GMTdavid_englert@urmc.rochester.edu Optical System for a Large Axial Scan Depth Anterior Segment Optical Coherence Tomography (OCT), 28 Feb 2011 08:34:29 GMTdavid_englert@urmc.rochester.edu on a Chip, 14 Feb 2011 11:28:18 GMTdavid_englert@urmc.rochester.edu Use of Rad51 Promoter Constructs in Anticancer Therapy, 29 Oct 2010 11:28:47 GMTdavid_englert@urmc.rochester.edu Pulse-Train Generator, 18 Oct 2010 10:51:44 GMTdavid_englert@urmc.rochester.edu Multidimensional Real-Time Pain Monitoring System, 18 Oct 2010 10:50:54 GMTdavid_englert@urmc.rochester.edu Fuel Cell Membrane Containing Aligned Ion-Conducting Pathways, 18 Oct 2010 10:50:49 GMTdavid_englert@urmc.rochester.edu Class of Antifungal Agents, 20 Sep 2010 06:52:02 GMTdavid_englert@urmc.rochester.edu Optics Scanning Laser Ophthalmoscope, 27 Aug 2010 10:19:24 GMTdavid_englert@urmc.rochester.edu Mouse Strain- a Unique System for Spatiotemporal and Lineage-specific Gene Expression, 23 Aug 2010 12:49:07 GMTdavid_englert@urmc.rochester.edu Antibody, 23 Aug 2010 12:49:01 GMTdavid_englert@urmc.rochester.edu of Phase for Full Range Doppler OCT, 04 May 2010 13:47:13 GMTdavid_englert@urmc.rochester.edu -- A Prefilled Mix and Inject Syringe System, 04 May 2010 13:47:08 GMTdavid_englert@urmc.rochester.edu Recombinant Activated Protein C, 04 May 2010 13:46:45 GMTdavid_englert@urmc.rochester.edu Finishing Fluid with Zirconia-Coated Carbonyl Iron for Optics Fabrication, 23 Oct 2009 11:31:46 GMTdavid_englert@urmc.rochester.edu anti-GPR56 Antibody Recognizes GPR56 on Formalin-Fixed Paraffin-Embedded Human Tissue Sections, 15 Oct 2009 12:06:14 GMTdavid_englert@urmc.rochester.edu Transcutaneous Energy Transfer (TET) Device A ventricular assist device (VAD) is an auxiliary blood circulation pump. It is implanted to assist the left, right or both ventricles to enhance circulation. The power source is worn externally by the patient with a cable going through the skin. The opening in the skin becomes a portal for serious infection which may also travel to the heart. Numerous attempts have been made over the years to power VADs transcutaneously. Almost all such attempts have been of some variation of electromagnetic energy transfer from a sending coil outside the body to a receiving coil inside...Thu, 15 Oct 2009 12:06:09 GMTdavid_englert@urmc.rochester.edu Antibodies to Dengue Fever NS1, 17 Jun 2009 12:03:04 GMTdavid_englert@urmc.rochester.edu Antibodies to Dengue Fever E Protein, 17 Jun 2009 12:03:03 GMTdavid_englert@urmc.rochester.edu Host Polymer for Electro-Phosphorescent OLEDs, 17 Jun 2009 12:03:00 GMTdavid_englert@urmc.rochester.edu for Adaptive Optics: TsunamiSLO Brief Description: The software provides user-friendly control of devices needed for adaptive optics: wavefront sensor (Shack-Hartmann or other) with a digital camera, wavefront corrector (such as Boston Micromachines deformable mirror, or ImagineEyes deformable mirror), laser controller (such as Thorlabs ITC-502 or other) and power meters (such as Newport 1930 or other). Applications: For the control of wavefront sensors and aberration correction devices used in adaptive optics in scanning laser ophthalmoscopes, optical coherence tomography and other research applications of adapti...Wed, 17 Jun 2009 12:02:45 GMTdavid_englert@urmc.rochester.edu Capacity Embedding in Printed Images by Halftone Orientation Modulation, 17 Jun 2009 12:02:38 GMTdavid_englert@urmc.rochester.edu for Computing Zernike Characterization of an Optical Wave Front: TsunamiWave, 17 Jun 2009 12:02:36 GMTdavid_englert@urmc.rochester.edu, Decoupled Hardware-Accelerated Transactional Memory, 17 Jun 2009 12:02:30 GMTdavid_englert@urmc.rochester.edu Sensitivity Interferometers Using Slow- and Fast-Light, 17 Jun 2009 12:02:28 GMTdavid_englert@urmc.rochester.edu Look-Up Tables with Lossless Compression, 17 Jun 2009 12:02:26 GMTdavid_englert@urmc.rochester.edu Illumination Imaging for in-vitro Microscopy and in-vivo Retinal Imaging Brief Description: In structured illumination microscopy, an object is illuminated by sinusoidally patterned light, rather than conventional uniform illumination, and digital image processing is done to obtain axial sectioning (3D imaging) and super-resolution (imaging at frequencies beyond the normal diffraction cutoff of the optical system). Applications: The technique can be used in microscopes for imaging both fluorescent and non-fluorescent objects, such as tissues, cells and micro-structures such as semiconductor chips, in both in vitro and in vivo applications. A key in vivo a...Wed, 17 Jun 2009 12:02:23 GMTdavid_englert@urmc.rochester.edu PN Junction, 17 Jun 2009 12:02:21 GMTdavid_englert@urmc.rochester.edu of Optical Pulses with Enhanced Dynamic-Range and Increased Bandwith, 17 Jun 2009 12:02:18 GMTdavid_englert@urmc.rochester.edu Imaging System, 17 Jun 2009 12:02:17 GMTdavid_englert@urmc.rochester.edu Bistable Display Using Electrowetting and Liquid Dielectrophoresis, 17 Jun 2009 12:02:15 GMTdavid_englert@urmc.rochester.edu Imaging of Tissue Stiffness by Spatially Modulated Acoustic Radiation Force Impulse (SM-ARFI), 17 Jun 2009 12:02:13 GMTdavid_englert@urmc.rochester.edu Algorithm for Simulating On-Chip RLC Interconnects, 17 Jun 2009 12:02:12 GMTdavid_englert@urmc.rochester.edu Arbitrary Waveform Generator, 17 Jun 2009 12:02:10 GMTdavid_englert@urmc.rochester.edu for Nano-Structuring Metal Surfaces by Femto-Second Laser Machining, 17 Jun 2009 12:02:09 GMTdavid_englert@urmc.rochester.edu Management System and Method for Fluid Dispensing and Coating, 17 Jun 2009 12:02:08 GMTdavid_englert@urmc.rochester.edu Deflection Transistor and Ballistic Deflection Transistor Based Logic Circuits, 17 Jun 2009 12:02:08 GMTdavid_englert@urmc.rochester.edu Music and Audio Via Embedded Data in MP3 Files, 17 Jun 2009 12:02:07 GMTdavid_englert@urmc.rochester.edu Parallelization for Multi-Processor Computers, 17 Jun 2009 12:02:06 GMTdavid_englert@urmc.rochester.edu Software for X-ray Spectroscopy with an SXX-100, 17 Jun 2009 12:02:05 GMTdavid_englert@urmc.rochester.edu sensor with a Current Sensing Active Pixel (CSAP), 17 Jun 2009 12:02:03 GMTdavid_englert@urmc.rochester.edu Imaging of Low Light Signals, 17 Jun 2009 12:02:02 GMTdavid_englert@urmc.rochester.edu MEMs Amplitude and Phase Control of an Optical Wavefront, 17 Jun 2009 12:01:59 GMTdavid_englert@urmc.rochester.edu Transactional Memory, 17 Jun 2009 12:01:53 GMTdavid_englert@urmc.rochester.edu Sensor with a Sigma-Delta ADC Using Only 3 and 4 Transistors/Pixel, 17 Jun 2009 12:01:53 GMTdavid_englert@urmc.rochester.edu Amplifiers with Built-In Filtering for UWB Impulse Radio, 17 Jun 2009 12:01:51 GMTdavid_englert@urmc.rochester.edu Optical Biosensor, 17 Jun 2009 12:01:45 GMTdavid_englert@urmc.rochester.edu Size Detection by Interferometry, 17 Jun 2009 12:01:43 GMTdavid_englert@urmc.rochester.edu and Apparatus to Reduce Noise Fluctuations in On-Chip Power Distribution Networks, 17 Jun 2009 12:01:41 GMTdavid_englert@urmc.rochester.edu Imaging with Adaptive Optics Optical Coherence Tomography (AO-OCT), 17 Jun 2009 12:01:32 GMTdavid_englert@urmc.rochester.edu Engineered Clostridium Thermocellum for Ethanol Production from Cellulose, 17 Jun 2009 12:01:30 GMTdavid_englert@urmc.rochester.edu Distortion Compensation Using a “Blind System Identification” Method, 17 Jun 2009 12:01:28 GMTdavid_englert@urmc.rochester.edu Open-Channel DEP Cell Sorting Integrated with DEP Microfluidic System, 17 Jun 2009 12:01:26 GMTdavid_englert@urmc.rochester.edu of an Image Mosaic, 17 Jun 2009 12:01:25 GMTdavid_englert@urmc.rochester.edu Detection and Object Discovery in Video, 17 Jun 2009 12:01:21 GMTdavid_englert@urmc.rochester.edu Authentification and Data Embedding, 17 Jun 2009 12:01:15 GMTdavid_englert@urmc.rochester.edu Gain Bulk-Driven Operational Amplifiers for SOC Applications, 17 Jun 2009 12:01:14 GMTdavid_englert@urmc.rochester.edu to Predict the Subjective Impact of the Eye's Wave Aberration, 17 Jun 2009 12:01:12 GMTdavid_englert@urmc.rochester.edu Materials for Polarized, Tunable Color (and White) Emission, 17 Jun 2009 12:01:08 GMTdavid_englert@urmc.rochester.edu Control Protocol for Energy Efficiency in Ad-Hoc Networks, 17 Jun 2009 12:01:05 GMTdavid_englert@urmc.rochester.edu Control Protocol for Energy Efficiency, 17 Jun 2009 12:01:01 GMTdavid_englert@urmc.rochester.edu Affinity Analysis Optimization for Software Performance, 17 Jun 2009 12:00:59 GMTdavid_englert@urmc.rochester.edu Metric for Computing Subjective Sharpness From Wave Sensor Data, 17 Jun 2009 12:00:55 GMTdavid_englert@urmc.rochester.edu Logic with Variable Threshold Voltage Keeper invention offers a high speed, low power domino logic circuit for microprocessors. The design involves a dynamic body biased keeper circuit which simultaneously reduces power consumption and enhances speed.. Applications For CMOS logic circuits requiring high speed. Advantages Domino CMOS logic circuits which are commonly used in high performance microprocessors for their high speed and area characteristics, are highly sensitive to noise as compared to static gates. In standard domino logic gates, a feedback keeper is employed to maintain the state of the dynamic node against coupling n...Wed, 17 Jun 2009 12:00:54 GMTdavid_englert@urmc.rochester.edu Integrated Spaced Sequence of Resonators (SCISSOR), 17 Jun 2009 12:00:46 GMTdavid_englert@urmc.rochester.edu Analog to Digital Converter Architecture Based upon a Novel Modulator Design Employing a Mirrored Integrator, 17 Jun 2009 12:00:42 GMTdavid_englert@urmc.rochester.edu Issue Queue for Reduced Power at High Performance, 17 Jun 2009 12:00:41 GMTdavid_englert@urmc.rochester.edu of High Temperature Materials by Combustion Synthesis and Semi-Solid Forming, 17 Jun 2009 12:00:33 GMTdavid_englert@urmc.rochester.edu Objective Method to Determine the Ocular Refraction from Wavefront Aberration Data and to Design an Optimum Customized Correction of a Set of a Few Higher-Order Aberrations, 17 Jun 2009 12:00:29 GMTdavid_englert@urmc.rochester.edu Single Photon Detector, 17 Jun 2009 12:00:26 GMTdavid_englert@urmc.rochester.edu Optical Flip Flop Using a Resonant-Type Semiconductor Optical Amplifier, 17 Jun 2009 12:00:22 GMTdavid_englert@urmc.rochester.edu Leukemia Cells in a Bio-Reactor for Drug Discovery and Diagnosis, 17 Jun 2009 12:00:20 GMTdavid_englert@urmc.rochester.edu, Automatic Measurement of the Eye's Wave Aberration, 17 Jun 2009 12:00:18 GMTdavid_englert@urmc.rochester.edu Optical Pulse Measurement Using a Spectral Shearing Interferometer, 17 Jun 2009 12:00:04 GMTdavid_englert@urmc.rochester.edu Chiral Nematic Polymers material is a glassy thermotropic chiral nematic liquid crystalline composition with low molar mass, which is used for forming optical devices with clear transparent films that selectively reflect visible and near-infrared circular-polarized light, but do not absorb light in the visible region. Applications This material can be used in circular polarizing filters, selective reflectors, beam splitters, beam apodizers or notch filters. Advantages Currently, low molecular weight liquid crystal materials have many limitations including durability, effective temperature, mesophase stability,...Wed, 17 Jun 2009 11:59:54 GMTdavid_englert@urmc.rochester.edu Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye, 17 Jun 2009 11:59:41 GMTdavid_englert@urmc.rochester.edu Carrying Null or Conditional Mutations in the Bambi Gene, 17 Jun 2009 11:59:37 GMTdavid_englert@urmc.rochester.edu Behavior Observational Instrument, 17 Jun 2009 11:59:36 GMTdavid_englert@urmc.rochester.edu Schedule - A Web-based Software Solution for Nursing Staff Schedule Management, 17 Jun 2009 11:59:33 GMTdavid_englert@urmc.rochester.edu Ontology Mapper, 17 Jun 2009 11:59:30 GMTdavid_englert@urmc.rochester.edu Shade, 17 Jun 2009 11:59:05 GMTdavid_englert@urmc.rochester.edu Enhancing Platelet Production Applications: The invention identifies novel compounds that enhance platelet production in cases where platelet number is low, such as after ionizing radiation exposure, chemotherapy, and autoimmunity. Advantages: Existing therapy such as TPO (thrombopoietin) only enhances production of megakaryocytes but does not directly enhance the production of platelets.Wed, 17 Jun 2009 11:59:02 GMTdavid_englert@urmc.rochester.edu Plasminogen Activator Inhibitor-1 (PAI-1) for the Treatment or Prevention of Acute Lung Injury and Death in Severe Pulmonary Infection, 17 Jun 2009 11:58:44 GMTdavid_englert@urmc.rochester.edu KC-NL Crosstalk Subversion by HCV, 17 Jun 2009 11:58:42 GMTdavid_englert@urmc.rochester.edu Kinase C-Associated Kinase PKK is Required for NF-kB Signaling and Survival in Diffuse Large-B Cell Lymphoma Cells, 17 Jun 2009 11:58:38 GMTdavid_englert@urmc.rochester.edu of a Novel Stem Cell Marker Applications: The invention identifies a Novel Stem Cell Marker Gpr177, a G Protein-coupled Receptor. Gpr177 is a useful marker in the identification, isolation and characterization of specific stem cell population, including neural stem cells in specific regions of the brain and spinal cord, and cancer stem cells as well. Advantages: The Gpr177-expressing stem cells have potential for the treatment of the brain and spinal cord injuries, the neuromuscular malfunction, and the learning and memory disorders. Because Gpr177 presents in unglycosylated and glycosylated forms, it is also ...Wed, 17 Jun 2009 11:58:37 GMTdavid_englert@urmc.rochester.edu Model of Chronic Viral Hepatitis Applications: The invention generates a novel mouse model of acute and chronic T cell mediated hepatitis, which shares some important features with viral hepatitis in man. The mouse model is valuable in identifying drug targets for viral hepatitis. Advantages: The mouse model is driven directly by CD8+ T cell and results from the recognition of an antigen that is expressed in a minority of hepatocytes. The mouse model does not depend on transgenic expression of the antigen and is not complicated by immune self-tolerance. The model results in the induction of genes associated with li...Wed, 17 Jun 2009 11:58:36 GMTdavid_englert@urmc.rochester.edu Intra-Ocular Pressure Regulating Device, 17 Jun 2009 11:58:30 GMTdavid_englert@urmc.rochester.edu Training Curriculum for Mental Health and Spiritual Care Professionals in Healthcare Settings is a set of disaster behavioral health training materials for health and non-healthcare workers (Tech IDs: 6-1583-86). Applications The materials will be used to train behavioral health, spiritual care and other community helpers to respond to the needs of individuals impacted by disasters and public health emergencies. It can be utilized by state and local health and mental health agencies and other disaster response organizations to train their personnel. The curriculum titled ?Disaster Mental Health: A Critical Response? is composed of the following:. Instructor Edition (6-1583). Inst...Wed, 17 Jun 2009 11:58:26 GMTdavid_englert@urmc.rochester.edu Training Curriculum for Mental Health and Spiritual Care Professionals in Healthcare Settings This is a set of disaster behavioral health training materials for health and non-healthcare workers (Tech IDs: 6-1583-86). Applications The materials will be used to train behavioral health, spiritual care and other community helpers to respond to the needs of individuals impacted by disasters and public health emergencies. It can be utilized by state and local health and mental health agencies and other disaster response organizations to train their personnel. The curriculum titled ?Disaster Mental Health: A Critical Response? is composed of the following:. Instructor Edition (6-1583). Ins...Wed, 17 Jun 2009 11:58:24 GMTdavid_englert@urmc.rochester.edu Training Curriculum for Mental Health and Spiritual Care Professionals in Healthcare Settings This is a set of disaster behavioral health training materials for health and non-healthcare workers (Tech IDs: 6-1583-86). Applications The materials will be used to train behavioral health, spiritual care and other community helpers to respond to the needs of individuals impacted by disasters and public health emergencies. It can be utilized by state and local health and mental health agencies and other disaster response organizations to train their personnel. The curriculum titled ?Disaster Mental Health: A Critical Response? is composed of the following:. Instructor Edition (6-1583). Ins...Wed, 17 Jun 2009 11:58:23 GMTdavid_englert@urmc.rochester.edu Training Curriculum for Mental Health and Spiritual Care Professionals in Healthcare Settings, 17 Jun 2009 11:58:22 GMTdavid_englert@urmc.rochester.edu Therapeutic Agents, Diagnostics, and Sensors Applications: Carbohydrates represent a particularly enticing and important challenge to the organic chemist interested in molecular recognition. In addition to their role in addressing the fundamental problem of understanding binding and selectivity, novel carbohydrate receptors have significant potential as tools in the rapidly evolving field of glycomics, as components of sensing systems for isolated sugar and for pathogens, and as leads for the development of new therapeutic agents. The invention identifies a small molecule that binds carbohydrates with high affinity via non-covale...Wed, 17 Jun 2009 11:58:04 GMTdavid_englert@urmc.rochester.edu Melanin Expression, 17 Jun 2009 11:57:59 GMTdavid_englert@urmc.rochester.edu Small Molecules as Potential Antiviral Therapy (HIV, SARS etc), 17 Jun 2009 11:57:57 GMTdavid_englert@urmc.rochester.edu Release Beads for a Quantitative ELISPOT or FLORISPOT Assay Applications: This research has developed a method to quantify the specific amount of antigen released by cells in an ELISPOT assay. Advantages: Currently, an ELISPOT assay can only quantify the number of cells producing a particular antigen. This technology allows the user to create a standard curve for antigen release and determine the actual amount of antigen released by the cells.Wed, 17 Jun 2009 11:57:48 GMTdavid_englert@urmc.rochester.edu<![CDATA[Reagents Identifying PPARγ Isoforms]]> Reagents can be used for commercial western blot/ELISA/Flow Cytometry. Advantages: Currently there are no proven reagents that distinguish PPAR gamma isoforms.Wed, 17 Jun 2009 11:57:37 GMTdavid_englert@urmc.rochester.edu Portal/Web Bed Board, 17 Jun 2009 11:57:24 GMTdavid_englert@urmc.rochester.edu Nanoparticles (PKNs): a Novel Macrophage-Selective Drug-Delivery System, 17 Jun 2009 11:57:23 GMTdavid_englert@urmc.rochester.edu Knockout Mouse Applications: The Kcnn4 Knockout Mouse model will be helpful for developing treatment for sickle cell anemia and diarrhea. Advantages: Kcnn4 Knockout Mouse model can be used for testing function, related genetic diseases and treatment related to the Kcnn4 gene.Wed, 17 Jun 2009 11:57:19 GMTdavid_englert@urmc.rochester.edu Biliverdin Reductase is a New Member of the Insulin Receptor Substrate Family with Serine/Threonine/Tyrosine Kinase Activity, 17 Jun 2009 11:57:15 GMTdavid_englert@urmc.rochester.edu Blood Pressure Screening Wheel, 17 Jun 2009 11:57:06 GMTdavid_englert@urmc.rochester.edu Model to Study the Role of IL-1ß in Neurodegeneration and Brain Injury Applications: A novel transgenic mouse model was created to investigate the role of IL1ß in neurodegeration and brain injury. This model may also be used to test existing and novel drugs and therapies for suppression of neuroinflammation associated with brain disorders. Advantages: Creation of conditionally expressed IL1ß and IL-1A (receptor antagonist) mice provides an important tool for dissection of the role of IL-1 in brain and newrodegeration.Wed, 17 Jun 2009 11:57:05 GMTdavid_englert@urmc.rochester.edu Model of Osteoarthritis: Over-Expression of Smurf2 in Cartilage to Induce Disease and Over-expression of Smurf1 as a Potential Therapeutic Strategy, 17 Jun 2009 11:56:54 GMTdavid_englert@urmc.rochester.edu GST-Tagged Vitronectin Can Be Used as a Cell-Culture Substratum, 17 Jun 2009 11:56:52 GMTdavid_englert@urmc.rochester.edu Cell Lines for the Study of Long QT Syndrome As part of a study on Long QT syndrome, these cell lines were obtained from approximately 600 affected and unaffected individuals are available for license in other fields of cardiac research.Wed, 17 Jun 2009 11:56:49 GMTdavid_englert@urmc.rochester.edu Antimuscarinic Compounds for the Treatment of Bladder Diseases, 17 Jun 2009 11:56:24 GMTdavid_englert@urmc.rochester.edu for Use in Cocaine Abuse with Reduced Opoid Side Effects, 17 Jun 2009 11:56:08 GMTdavid_englert@urmc.rochester.edu Antibodies to Yellow Fever E Protein, 17 Jun 2009 11:56:02 GMTdavid_englert@urmc.rochester.edu of Enhanced Green Fluorescence Protein in Pulmonary Type II Epithelial Cells of Mice, 17 Jun 2009 11:55:57 GMTdavid_englert@urmc.rochester.edu Autoinducer Molecules and Uses Therefore (Quinoline Signaling in the Cell-to-Cell Communication), 17 Jun 2009 11:55:55 GMTdavid_englert@urmc.rochester.edu of Molecular Techniques to Identify Regulators of Bone Formation, 17 Jun 2009 11:55:54 GMTdavid_englert@urmc.rochester.edu Mouse Model of Parkinson's Disease Containing Either Wild-Type or Doubly-Mutated Human Alpha-synuclein, 17 Jun 2009 11:55:50 GMTdavid_englert@urmc.rochester.edu LR Mice (Mouse Model of Myotonic Dystrophy), 17 Jun 2009 11:55:49 GMTdavid_englert@urmc.rochester.edu Mouse Line that Lacks Phosphoinositide, 17 Jun 2009 11:55:46 GMTdavid_englert@urmc.rochester.edu for CARE-HD Trial Sponsored by NINDS Applications: The database provides information on whether remacemide and/or coenzyme Q can effectively treat Huntington's disease. Advantages: The database is a unique collection of data from 30 months of clinical trials. Technology Status: The database is ready for use.Wed, 17 Jun 2009 11:55:43 GMTdavid_englert@urmc.rochester.edu Responsive lacZ Mouse Model Applications: The mouse model provides a useful tool for both the examination of the endogenous role of the Ah receptor in proliferation or differentiation and of the developmental targets of dioxin-like compounds. Advantages: A useful model for studying how dioxin-like compounds affects Ah receptors in vivo.Wed, 17 Jun 2009 11:55:36 GMTdavid_englert@urmc.rochester.edu Cell Line Capable of Sensing HIF-1alpha Activation in the CNS for Use in Screening Pharmacologic Agents Capable of Activating/Attenuating Hypoxic Activated Gene Transcription This technology describes a stable reporter cell line that measures the expression of hypoxia-inducible-1-alpha (HIF-1a), a transcriptional activator, which is useful in screening compound libraries for anti-ischemic, neuroprotective and tumor pro-apoptotic activity. Drug candidates identified with this technology could potentially address therapies for central nervous system ischemia, cardiac ischemia, and cancer. Advantages: This cell lines offer a fast and economical tool to learn how drug leads can regulate pathologic hypoxia-dependent transcriptional processes such ...Wed, 17 Jun 2009 11:55:33 GMTdavid_englert@urmc.rochester.edu Methods For Calibrating Predictive Models for P450, 17 Jun 2009 11:55:31 GMTdavid_englert@urmc.rochester.edu Model for the Testing of Allergens and Irritants, 17 Jun 2009 11:55:26 GMTdavid_englert@urmc.rochester.edu Mice Expressing Human PSA, 17 Jun 2009 11:55:18 GMTdavid_englert@urmc.rochester.edu Immortalized Retinal (E1A-NR.3) Cell Culture Applications The established retinal cell line retains retinal properties, is non-tumorigenic but immortal. It is ideal for in-vitro drug screening. Advantages It is one of very few retinal cell lines. Technology Status E1 cell line is ready for use.Wed, 17 Jun 2009 11:55:17 GMTdavid_englert@urmc.rochester.edu<![CDATA[Hybridoma Cell Line & Monoclonal Antibodies Named IV.3]]>, 17 Jun 2009 11:55:08 GMTdavid_englert@urmc.rochester.edu Osteoclast Precursors as Markers of Bone Resorption in Inflammatory Arthritis, 05 May 2009 12:22:03 GMTdavid_englert@urmc.rochester.edu Induced Blood Stasis and in vivo Optical Spectroscopy Thereof, 05 May 2009 11:30:01 GMTdavid_englert@urmc.rochester.edu Antibodies to von Willebrand Factor Propolypeptide (VWFpp), 05 May 2009 11:30:01 GMTdavid_englert@urmc.rochester.edu in-vivo Imaging of Mechanoreceptors in Human Skin Using Confocal Microscopy, 05 May 2009 11:30:00 GMTdavid_englert@urmc.rochester.edu Human Papillomavirus (HPV) Chimeric Virus Like Particle (cVLP)-Based Gene Delivery System for Phrophylaxis and Immunotherapy of Infectious Diseases, 04 May 2009 14:19:36 GMTdavid_englert@urmc.rochester.edu Outersurface Protein A Fragment as a Lyme Disease Vaccine, 04 May 2009 14:19:32 GMTdavid_englert@urmc.rochester.edu Immunization Against Papillomavirus Disease Description: This invention is a method of vaccinating against human papillomavirus (HPV) by using papillomavirus ?virus-like particles? transcutaneously to induce an immune response to the virus. Applications: Papiloma viruses constitute a group of DNA viruses that induce both lytic infections and either benign or malignant tumors. Papiloma viruses infect cutaneous, genital, oral, and respiratory epithelia in a tissue-specific manner. Infection with HPV has been associated closely with plantar warts, condylomata acuminata (anogenital warts), and premalignant and malignant lesio...Mon, 04 May 2009 14:19:31 GMTdavid_englert@urmc.rochester.edu Human Fc Receptor-Transformed Cell Lines to Detect Virus-Neutralizing and Enhancing Antibodies, 04 May 2009 08:54:55 GMTdavid_englert@urmc.rochester.edu and Treatment of Interstitial Cystitis, 17 Apr 2009 13:12:06 GMTdavid_englert@urmc.rochester.edu - A Database Solution for the Management of Clinical Trial Recruitment, 17 Apr 2009 12:54:36 GMTdavid_englert@urmc.rochester.edu II Blood Samples, 17 Apr 2009 11:52:23 GMTdavid_englert@urmc.rochester.edu molecules Manipulation of G Protein Subunit Signaling for Chronic Pain Management and Opioid-Tolerance, 17 Apr 2009 11:45:51 GMTdavid_englert@urmc.rochester.edu the Risk for Recurrent Heart Attack(s), 17 Apr 2009 11:19:36 GMTdavid_englert@urmc.rochester.edu Novel Approach to Treating Multiple Diseases by Small Molecule Targeting of G-Proteins - One Step Beyond GPCRs, 17 Apr 2009 09:13:11 GMTdavid_englert@urmc.rochester.edu of Molecular Mediators in TNF-Signaling (Inflammation) for the Treatment of Cardiovascular Diseases Such as Atherosclerosis, Stroke, and Ischemia/Reperfusion Injury, 17 Apr 2009 08:59:25 GMTdavid_englert@urmc.rochester.edu Factor Pathway Inhibition as a Treatment Strategy for Severe Pulmonary Arterial Hypertension, 15 Apr 2009 13:47:11 GMTdavid_englert@urmc.rochester.edu Cell Preparations for Allogeneic Repair of Injured Human White Matter, 13 Apr 2009 12:08:29 GMTdavid_englert@urmc.rochester.edu Chimeric Model to Assess in vivo Response of Human Glial to Injury, Disease Perturbation, and Drug Treatment Applications: The invention has generated chimeric human-mouse brains in which the relative proportion of human astrocytes and oligodendrocytes is quite high, often exceeding 50% of all cells in the adult white matter. More over, researchers have established mice in which 100% of myelin, in substantially normal myelinated brain, is of human origin. Advantages: In vivo responses of human glia -including glial progenitor cells, astrocytes, and oligodendrocytes- to injury and disease states may be imaged and biochemically assessed, in a mouse model that permits disease perturbation, drug treatm...Mon, 13 Apr 2009 08:33:16 GMTdavid_englert@urmc.rochester.edu Model of Osteoarthritis Osteoarthritis (OA) is a common degenerative joint disease and currently there is no effective treatment for the diseases. We have generated a conditional activation genetic mouse model that can help to identify new drugs for the prevention and treatment of osteoarthritis. The mouse model can also test the effect and efficacy of existing or newly identified osteoarthritis drugs. Advantages: Using the mouse model, we demonstrate for the first time that over expression of a key gene in articular chondrocytes leads to the development of OA in adult mouse.Fri, 10 Apr 2009 09:06:03 GMTdavid_englert@urmc.rochester.edu and Regeneration of Articular Cartilage, and the Repair and Regeneration of Fibrocartilaginous Tissues, 06 Apr 2009 13:03:49 GMTdavid_englert@urmc.rochester.edu Tendon Allografts as Delivery Vehicles for Genes, 06 Apr 2009 13:03:39 GMTdavid_englert@urmc.rochester.edu to Correct for Skeletal Lead Interference in Bone Mineral Density Measurements, 06 Apr 2009 13:03:36 GMTdavid_englert@urmc.rochester.edu Affinity Binding Proteins to Integrins This technology is related to the development of high affinity binding proteins to specific integrin proteins highly associated with cancer metastasis. Applications of these targeting molecules include tumor imaging, targeted tumor therapy, and targeted gene delivery. Advantages: These molecules are more stable, easier to make, and more amenable to protein engineering techniques than short peptides and antibodies.Mon, 30 Mar 2009 08:35:05 GMTdavid_englert@urmc.rochester.edu Platform for Intratumoral Delivery (RAPID) System, 27 Mar 2009 13:03:07 GMTdavid_englert@urmc.rochester.edu Therapy with Spatially-Resolved Dual Spectroscopic Monitoring and Related System Description: Since 2003, a collaborative research effort between researchers at the University of Rochester Medical Center (URMC) and the Roswell Park Cancer Institute (RPCI) has resulted in the development of a system for delivery of photodynamic therapy(PDT) for the treatment of cancer with capabilities for realtime spectroscopic monitoring and feedback controlled dosimetry. Applications: This invention involves instrumentation developed for delivery of spatially resolved photodynamic therapy(PDT) in vivo, employing real-time measurements of fluorescence emission spectra correc...Tue, 24 Mar 2009 13:18:54 GMTdavid_englert@urmc.rochester.edu