Search Results - ian nicholas crispe

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Human KC-NL Crosstalk Subversion by HCV
Applications:The invention has developed an in vitro culture system based on the isolation of human Kupffer cells (KC) and natural Killer Cells (NK) from the donated liver grafts. The model can be used for the identification of drug targets of viral hepatitis, and for testing drugs and biologics.Advantages:The model uses human cells directly from the...
Published: 6/17/2009   |   Inventor(s): Mark Orloff, Ian Nicholas Crispe
Keywords(s): Cell Signalling, Immunology, Research Tool, Therapy
Category(s): Research Tools
Mouse Model of Chronic Viral Hepatitis
Applications:The invention generates a novel mouse model of acute and chronic T cell mediated hepatitis, which shares some important features with viral hepatitis in man. The mouse model is valuable in identifying drug targets for viral hepatitis.Advantages:The mouse model is driven directly by CD8+ T cell and results from the recognition of an antigen...
Published: 6/17/2009   |   Inventor(s): Ian Nicholas Crispe, Robert Pierce
Keywords(s): Gastrointestinal, Hepatic, Mouse, Research Tool, Viral disease
Category(s): Research Tools