Modulating Melanin Expression

Brief Description
Compounds which can induce melanin expression to aid in certain clinical indications or for cosmetic purposes.
 
Problem Solved by This Technology

Melanin is important for disease prevention, because it absorbs ultraviolet light in the UVB and UVA spectrum. This protects keratinocytes from the mutagenic effects of sunlight. In addition, melanin has a social function, as it determines skin and hair color.
Agents that increase melanin synthesis are of interest, because of their potential use as “natural sunscreens” that stimulate the skin’s resident melanocytes to produce and transfer more melanin to epidermal keratinocytes, thus potentially decreasing the incidence of skin cancer.
There is a significant need to identify new compounds with improved ability to induce melanin production and transfer.
 
Applications
Benjamin Miller, Ph.D. and his colleagues at the University of Rochester have developed compounds which induce melanin expression in melanocytes, increase melanin content in keratinocytes, and increase skin pigmentation within a treated area of the skin.
The ability to modulate melanin expression is important in certain clinical conditions such as insufficient skin pigmentation, or for cosmetic purposes such as achieving a “sunless tan” or enhancing tanning with limited exposure to sunlight or ultraviolet light.
These compounds actually produce additional melanin in the skin, and thus protect the skin from ultraviolet radiation and may decrease the risk of skin cancer.
 
Publication
McNaughton BR et al. A potent activator of melanogenesis identified from small-molecule screening. ChemMedChem. 2009 Oct;4(10):1583-9. PMID:19670207.
 
Technology Status
Proof of Concept has been validated in-vitro.
UR Ventures is seeking an industry partner to further develop and commercialize this technology.
 
URV Reference Number
6-1539
Patent Information:
Title Country Patent No. Issued Date
Small Molecule Modulators of Melanin Expression United States 9,162,984 10/20/2015
Category(s):
Therapeutic
For Information, Contact:
Matan Rapoport
Licensing Associate
University of Rochester
585.276.6600
matan.rapoport@rochester.edu
Inventors:
Benjamin Miller
Brian McNaughton
Peter Gareiss
Glynis Scott
Keywords:
Cancer
Dermatology
Oncology
Small Molecule
Therapy