Search Results - musculoskeletal

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Methods For Determining The Presence Or Risk Of Developing Facioscapulohumeral Dystrophy (FSHD)

ApplicationsThis technology provides a DNA-based diagnostic method to determine the presence or the susceptibility of developing Facioscapulohumeral Dystrophy (FSHD) and also a method to treat FSHD.AdvantagesCurrently, the diagnostic test for FSHD1 requires pulse-field gel electrophoresis and Southern blotting to detect the contraction of the D4Z4 repeats,...

Published: 8/14/2023 | Inventor(s): Al-Rabi Tawil, Stephen Tapscott, Linda Geng, Silvere Van Der Maarel, Lauren Snider, Richard Lemmers

Keywords(s): Diagnostic, Musculoskeletal

Category(s): Diagnostic

HSA LR Mice (Mouse Model of Myotonic Dystrophy)

ApplicationsThe invention offers a transgenic mouse model for myotonic dystrophy. This mouse model expresses expanded CUG repeats and develops myotonia and myopathy. This model can be utilized to examine interactions between the loss- and gain-of-function effects of the mutation and to investigate the mechanism for nuclear retention and toxicity of...

Published: 8/14/2023 | Inventor(s): Charles Thornton

Keywords(s): Disease Model, Mouse, Musculoskeletal, Research Tool

Category(s): Research Tools

Repair and Regeneration of Articular Cartilage, and the Repair and Regeneration of Fibrocartilaginous Tissues

The invention provides methods for the protection, repair and regeneration of articular cartilage, and fibrocartilaginous tissues using recombinant parathyroid hormones, such the FDA approved biologic agent – teriparatide (Forteo®, Eli Lilly).Problem Solved by this TechnologyCurrently, the only treatments for cartilage degeneration and osteoarthritis...

Published: 2/14/2024 | Inventor(s): Randy Rosier, Michael Zuscik, Erik Sampson, Susan Bukata, J. Edward Puzas, Regis O'keefe, Hani Awad

Keywords(s): Arthritis, Musculoskeletal, Orthopaedics

Category(s): Therapeutic