HSA LR Mice (Mouse Model of Myotonic Dystrophy)

Brief Description
Applications
The invention offers a transgenic mouse model for myotonic dystrophy.  This mouse model expresses expanded CUG repeats and develops myotonia and myopathy.  This model can be utilized to examine interactions between the loss- and gain-of-function effects of the mutation and to investigate the mechanism for nuclear retention and toxicity of expanded CUG repeats.

Advantages
In vivo  model for muscular dystrophy.
Patent Information:
Category(s):
Research Tools
For Information, Contact:
Weimin Kaufman
Licensing Manager
University of Rochester
585.276.6608
weimin.kaufman@rochester.edu
Inventors:
Charles Thornton
Keywords:
Disease Model
Mouse
Musculoskeletal
Research Tool