HSA LR Mice (Mouse Model of Myotonic Dystrophy)
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The invention offers a transgenic mouse model for myotonic dystrophy. This mouse model expresses expanded CUG repeats and develops myotonia and myopathy. This model can be utilized to examine interactions between the loss- and gain-of-function effects of the mutation and to investigate the mechanism for nuclear retention and toxicity of expanded CUG repeats.
model for muscular dystrophy.
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University of Rochester
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