Search Results - randy+rosier

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Mouse Model of Osteoarthritis: Over-Expression of Smurf2 in Cartilage to Induce Disease and Over-expression of Smurf1 as a Potential Therapeutic Strategy

Applications:We have generated col2-promoter-Smad ubiquitin regulatory factor2 (col2-Smurf2) transgenic mice which possess a loss of TGFß signaling and display each of above characteristics, thus displaying a phenotype more representative of the disease process. Furthermore, the over-expression of Smurf2 in cartilage that has been induced in...

Published: 5/23/2023 | Inventor(s): Randy Rosier, Michael Zuscik, Qiugian Wu, Edward Schwarz

Keywords(s): Diagnostic, Therapy

Category(s): Research Tools

Repair and Regeneration of Articular Cartilage, and the Repair and Regeneration of Fibrocartilaginous Tissues

The invention provides methods for the protection, repair and regeneration of articular cartilage, and fibrocartilaginous tissues using recombinant parathyroid hormones, such the FDA approved biologic agent – teriparatide (Forteo®, Eli Lilly).Problem Solved by this TechnologyCurrently, the only treatments for cartilage degeneration and osteoarthritis...

Published: 2/14/2024 | Inventor(s): Randy Rosier, Michael Zuscik, Erik Sampson, Susan Bukata, J. Edward Puzas, Regis O'keefe, Hani Awad

Keywords(s): Arthritis, Musculoskeletal, Orthopaedics

Category(s): Therapeutic