Search Results - mouse

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Mice Carrying Null or Conditional Mutations in the Bambi Gene

Applications:The Bambi gene encodes an inhibitory pseudoreceptor for the Bmp/TGF-beta super-family of signaling molecules. The Bambi mutant mice will be useful for research and drug development for cardiovascular and musculoskeletal diseases, stem cell biology and cancer biology, liver function and homeostasis, immune system modulation, etc.Advantages:This...

Published: 5/23/2023 | Inventor(s): Rulang Jiang, Jianquan Chen, Jeffrey Bush

Keywords(s): Mouse, Research Tool

Category(s): Research Tools

Mouse Model of Chronic Viral Hepatitis

Applications:The invention generates a novel mouse model of acute and chronic T cell mediated hepatitis, which shares some important features with viral hepatitis in man. The mouse model is valuable in identifying drug targets for viral hepatitis.Advantages:The mouse model is driven directly by CD8+ T cell and results from the recognition of an antigen...

Published: 5/23/2023 | Inventor(s): Ian Nicholas Crispe, Robert Pierce

Keywords(s): Gastrointestinal, Hepatic, Mouse, Research Tool, Viral disease

Category(s): Research Tools

Transgenic Mouse Model of Parkinson's Disease Containing Either Wild-Type or Doubly-Mutated Human Alpha-synuclein

ApplicationsThis transgenic mouse model can be used to study Parkinson's Disease. The mouse model expresses a doubly mutated form of human alpha-synuclein. AdvantagesThis model has proven useful in understanding the pathogenesis of Parkinson's disease in humans and can be useful in designing rational interventions to slow or halt the course of the...

Published: 2/14/2024 | Inventor(s): Howard Federoff, Eric Richfield

Keywords(s): Mouse, Neurological, Research Tool

Category(s): Research Tools

HSA LR Mice (Mouse Model of Myotonic Dystrophy)

ApplicationsThe invention offers a transgenic mouse model for myotonic dystrophy. This mouse model expresses expanded CUG repeats and develops myotonia and myopathy. This model can be utilized to examine interactions between the loss- and gain-of-function effects of the mutation and to investigate the mechanism for nuclear retention and toxicity of...

Published: 8/14/2023 | Inventor(s): Charles Thornton

Keywords(s): Disease Model, Mouse, Musculoskeletal, Research Tool

Category(s): Research Tools

Mouse Model of Osteoarthritis

Applications: Osteoarthritis (OA) is a common degenerative joint disease and currently there is no effective treatment for the diseases. We have generated a conditional activation genetic mouse model that can help to identify new drugs for the prevention and treatment of osteoarthritis. The mouse model can also test the effect and efficacy...

Published: 5/23/2023 | Inventor(s): Di Chen

Keywords(s): Mouse, Orthopaedics, Osteoporosis

Category(s): Research Tools