Search Results - Therapeutic

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Compositions and methods for enhancing cardiac function in the neonate
The invention provides novel pharmaceutical compositions and methods for treating newborns in need of enhanced cardiac function, in particular, newborns suffering from cardiomyopathy, or a related disease or condition.
Published: 11/11/2019   |   Inventor(s): George Porter, Jr.
Keywords(s):  
Category(s): Therapeutic
URML-3881, a Novel MEK Inhibitor for the Treatment of Cancers
Provided herein, are compounds, compositions, and methods of treatment of cancers using an inhibitor of MAPK/ERK Kinase (MEK), in particular hydrazine derivatives.
Published: 11/6/2019   |   Inventor(s): Richard Moore, Rakesh Singh, Rachael Turner, Kyu Kwang Kim, Negar Khazan
Keywords(s):  
Category(s): Therapeutic
Broadly Neutralizing Anti-Influenza Human Monoclonal Antibodies and Uses Thereof
The present invention relates to broadly neutralizing anti-influenza monoclonal antibodies or antigen-binding fragments thereof. The present invention further relates to therapeutic uses of the isolated antibody or the antigen-binding fragment thereof.
Published: 11/6/2019   |   Inventor(s): James Kobie, Michael Piepenbrink, Michael Keefer, Luis Martinez-Sobrido, Aitor Nogales-Gonzalez
Keywords(s):  
Category(s): Therapeutic
Macrocyclic Inhibitors of the Human PGC1ß-CBP80 Protein-Protein Interaction
The invention provides compositions and methods for inhibiting protein- protein interactions with cap-binding protein 80 (CBP80). In one embodiment, the invention provides compositions comprising linear and macrocylic peptides. In one embodiment, the invention provides methods for treating cancer, heart disease, autoimmune disorders, obesity, diabetes,...
Published: 11/6/2019   |   Inventor(s): Lynne Maquat, Rudi Fasan
Keywords(s):  
Category(s): Therapeutic
Nanoparticle Therapeutics for Treating Skin Inflammatory Disorders
The present invention provides nanoparticles and methods for treating and preventing skin inflammatory conditions or disorders. The conditions or disorders include allergic contact dermatitis (ACD), irritant contact dermatitis, atopic dermatitis (AD), photoallergic dermatitis, and contact hypersensitivity (CHS), as well as other conditions or disorders...
Published: 11/6/2019   |   Inventor(s): Lisa Delouise, Samreen Jatana, Brian Palmer
Keywords(s):  
Category(s): Therapeutic, Nanotechnology
Concentrated Platelet Microparticles to Control Bleeding in Trauma Patients
The present disclosure is directed to blood dotting compositions comprising platelet microparticles, method of using said compositions, and methods of preparing the same.
Published: 11/5/2019   |   Inventor(s): Majed Refaai, Grace Conley
Keywords(s):  
Category(s): Therapeutic
Therapy for Malignant Disease
Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a...
Published: 11/5/2019   |   Inventor(s): Richard Moore, Rakesh Singh, Naohiro Yano
Keywords(s):  
Category(s): Therapeutic
Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method...
Published: 11/5/2019   |   Inventor(s): Rakesh Singh, Richard Moore
Keywords(s):  
Category(s): Therapeutic
N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
This invention comprises the innovative synthesis of N-amino tetrahydrothiazine free bases and their salts. This invention further comprises the use of the derivatives and their therapeutic application as anticancer agents. Further this invention comprises their manufacture and use.
Published: 11/5/2019   |   Inventor(s): Rakesh Singh, Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler
Keywords(s):  
Category(s): Therapeutic
LDH Inhibitors as Treatment for Fibrotic Disorders
One aspect of the disclosure relates to methods of treating a fibrotic condition in an individual. The methods include administering to an individual having a fibrotic condition an effective amount of a lactic dehydrogenase (LDH) inhibitor, wherein the fibrotic condition involves an internal organ or tissue, or ocular tissue, and said administering...
Published: 11/5/2019   |   Inventor(s): Robert Kottmann, Patricia Sime, Richard Phipps
Keywords(s):  
Category(s): Therapeutic
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