Search Results - Therapeutic

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Small Molecule Anti-Scarring Agents
Small molecule anti-scarring agents that may inhibit myofibroblast formation at the site of surgical trauma. Problem Solved by this Technology Scar formation is a normal physiological response to trauma or disease. Excessive, or hypertrophic, scarring is a debilitating condition that results in pain, loss of tissue function, and even death. Many t...
Published: 5/1/2017   |   Inventor(s): Richard Phipps, Collynn Woeller
Keywords(s): Collagen, Fibrosis, MKK6, Myofibroblast, p38, p38 MAPK, Polyether Ionophores, Salinomycin, SMAD Transcription Factor, TGFß
Category(s): Therapeutic
6-Bromoindirubin-3'-oxime Promotes Human Mesenchymal Stem Cell Proliferation, Stem Cell Phenotype, and Population Homogeneity
Applications: Currently, large orthopedic fractures (>3mm) presents a challenge clinically as proliferation of cells that differentiate into osteochondral cell types is required to heal the fracture. This technology provides a method, using a specific molecule, for inducing the proliferation of human mesenchymal stem cells (hMSC) in vitro. ...
Published: 3/16/2017   |   Inventor(s): Danielle Benoit, Michael Hoffman
Keywords(s):  
Category(s): Therapeutic
Early Detection of and Treatment for Neurodegenerative Diseases
A novel diagnostic test and therapeutic approach for neurodegenerative diseases, such as Alzheimer's disease. TechnologyResearchers at the University of Rochester have made a breakthrough discovery of the glymphatic pathway by which the brain clears its interstitial waste – a pathway resembling the discrete lymphatic system present in other p...
Published: 10/20/2016   |   Inventor(s): Maiken Nedergaard, Jeffrey Iliff
Keywords(s):  
Category(s): Therapeutic
Needle-Free Drug/Vaccine Delivery System
A novel peptide-based strategy for controlled transepithelial delivery of therapeutic molecules. Problem Solved by this TechnolgyTransdermal drug delivery systems (TDDS) are increasingly becoming an attractive alternative to the oral route as this method can avoid first pass effects, can provide steady drug plasma levels and is poised to replace pa...
Published: 9/1/2016   |   Inventor(s): Elizabeth Anderson, Anna De benedetto, Benjamin Miller, Lisa Beck
Keywords(s):  
Category(s): Therapeutic
A Novel Approach to Treatment of Hyperglycemia Using a Nano-Particle-Encapsulated Peptide
A novel approach to treat Type 2 diabetes. Problem solved by this Technology The highly inconvenient insulin injections remain the most prevalent treatment for Diabetes. By 2020, the global insulin market is expected to top $48 billion annually as insulin production costs are increasing and more insulin is being administered to diabetics due to de...
Published: 7/21/2016   |   Inventor(s): Mahin Maines
Keywords(s):  
Category(s): Therapeutic
Peptide Therapy for Inflammatory Bowel and Celiac Diseases
A safe and effective therapy based on the bacterial AvrA peptide for the treatment of inflammatory bowel and celiac diseases. Problem Solved by this Technology Successful therapeutic strategies for inflammatory bowel disease (IBD) or celiac disease must inhibit intestinal inflammation while maintaining the structural integrity of intestinal epithe...
Published: 6/6/2016   |   Inventor(s): Jun Sun
Keywords(s):  
Category(s): Therapeutic
Method for Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis via Detecting and Inhibiting Histone Methylation and Associated Proteins
Applications: Idiopathic pulmonary fibrosis (IPF) is marked by aberrant scarring of the lung tissue. IPF has multiple causes, including exposure to irritants such as asbestos and silica particles. In such cases a cytokines such as TGF-beta are known to induce fibrosis. The current invention identifies events resulting from TGF-beta signaling...
Published: 5/18/2016   |   Inventor(s): Xin Lin, Jia Guo, Steve Georas, Patricia Sime
Keywords(s): Diagnostic, Lung, Pulmonary
Category(s): Diagnostic, Therapeutic
Treatment for Female Infertility
A novel treatment for a variety of conditions resulting in female infertility. Problem Solved by this Technology Anti-Müllerian hormone (AMH) acts as a natural follicular gatekeeper limiting follicle growth initiation and maintains the primordial follicle pool during reproductive years. AMH is also an intra-ovarian regulator that inhibits follicula...
Published: 4/12/2016   |   Inventor(s): Aritro Sen, Norbert Gleicher
Keywords(s):  
Category(s): Therapeutic
Production of High Molecular Weight Hyaluronic Acid
A method of producing Hyaluronic Acid (HA) from naked mole rats that yields higher molecular weights than those produced by current industrial processes. Problem Solved by This Technology Dr. Gorbunova and her colleagues at the University of Rochester have discovered that naked mole rats skin cells produce and secret ultra-high molecular weight hy...
Published: 7/2/2015   |   Inventor(s): Vera Gorbunova, Andrei Seluanov
Keywords(s):  
Category(s): Therapeutic
The Depth Advancement Marker Needle for Image Guided Injections (DAMNIGI)
This novel, minimally invasive, needle device can be used to disrupt, cut or score tissue or deliver therapeutics, under image guidance, typically with CT or ultrasound. Applications: CT or ultrasound guided needle procedures are common practice. However, the depth of penetration of the needle is hard to gauge in the short axis because the plane o...
Published: 3/9/2015   |   Inventor(s): John Elfar
Keywords(s):  
Category(s): Devices, Imaging, Surgical/Medical Device, Therapeutic
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