Mouse Model of Chronic Viral Hepatitis
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The invention generates a novel mouse model of acute and chronic T cell mediated hepatitis, which shares some important features with viral hepatitis in man. The mouse model is valuable in identifying drug targets for viral hepatitis.
The mouse model is driven directly by CD8+ T cell and results from the recognition of an antigen that is expressed in a minority of hepatocytes. The mouse model does not depend on transgenic expression of the antigen and is not complicated by immune self-tolerance. The model results in the induction of genes associated with liver fibrosis.
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University of Rochester
Ian Nicholas Crispe
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