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Mouse Model of Osteoarthritis: Over-Expression of Smurf2 in Cartilage to Induce Disease and Over-expression of Smurf1 as a Potential Therapeutic Strategy

Applications:We have generated col2-promoter-Smad ubiquitin regulatory factor2 (col2-Smurf2) transgenic mice which possess a loss of TGFß signaling and display each of above characteristics, thus displaying a phenotype more representative of the disease process. Furthermore, the over-expression of Smurf2 in cartilage that has been induced in...

Published: 5/23/2023 | Inventor(s): Randy Rosier, Michael Zuscik, Qiugian Wu, Edward Schwarz

Keywords(s): Diagnostic, Therapy

Category(s): Research Tools