Search Results - drug design

5 Results Sort By:
3' Deoxy Nucleosides and Their Analogs as Anti-HIV Agents Targeting HIV-1 Macrophage Infection
3' Deoxy Nucleosides and Their Analogs as Anti-HIV Agents Targeting HIV-1 Macrophage Infection
Published: 4/29/2019   |   Inventor(s): Baek Kim
Keywords(s): Antiviral, Drug Design, HIV, Infectious Disease
Category(s): Therapeutic
Methods for Production of a Solution Assay and High-Throughput Screen to Probe the Interaction Between the Human Cullin-RING Ligase Complex and the HIV-1 Protein on a Muti-Milligram Scale
Brief Description:HIV-1 infection leads to the expression of the viral Vif protein which is essential to evade the host’s own A3G and A3F defense factors. Vif works in concert with the cell’s own ubiquitin ligase machinery to promote degradation of A3G and A3F. This requires a direct interaction between Vif and the human proteins Elongi...
Published: 4/29/2019   |   Inventor(s): Jason Salter, Joseph Wedekind, Harold Smith
Keywords(s): AIDS, Antiviral, Combinatorial Chemistry, Drug Design, HIV, HTS, Infection, Infectious Disease, Target Validation, Therapy, Viral disease
Category(s): Therapeutic
DNA Cell Lines for the Study of Long QT Syndrome
Applications:As part of a study on Long QT syndrome, these cell lines were obtained from approximately 600 affected and unaffected individuals are available for license in other fields of cardiac research.
Published: 6/17/2009   |   Inventor(s): Arthur Moss
Keywords(s): Blood, Cardiac, Database, Drug Design
Category(s): Research Tools
Reactivity/Selectivity Methods For Calibrating Predictive Models for P450
ApplicationsThis technology relates to the development of computational models for predicting rates of drug metabolism.AdvantagesThis method is the only one of its kind that allows for the quantitative prediction of metabolic regioselectivity. This approach assists in the assessment of metabolic properties of new drugs and in the redesign of promis...
Published: 6/17/2009   |   Inventor(s): Kenneth Korzekwa, Jeffrey Jones, Leeann Higgins
Keywords(s): Drug Design, Drug screening, Software
Category(s): Therapeutic
MADDIT II Blood Samples
Applications:This set of biological materials arose from a genetics research study at the University of Rochester in the area of sudden cardiac death. The University also possesses genotypic and phenotypic data related to each sample (subject) that participated in this study. The data collected during the course of the study is owned by a third pa...
Published: 4/17/2009   |   Inventor(s): Arthur Moss
Keywords(s): Blood, Cardiac, Database, Drug Design
Category(s): Diagnostic