Search Results - infectious disease

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Vaccine against Pneumocystis and Streptococcal Infections
Novel polypeptides and immunogenic conjugates capable of inducing passive and active immunity against Pneumocystis carinii and Streptococcus pneumoniae infections. Problem Solved by this TechnologyPneumocystis pneumonia (PCP), caused by an opportunistic pathogen Pneumocystis carinii, is a significant cause of morbidity and mortality in immunocompro...
Published: 9/21/2016   |   Inventor(s): Francis Gigliotti, Terry Wright, Constantine Haidaris, Patricia Simpson-Haidaris
Keywords(s): Antibody, Infectious Disease, Therapy
Category(s): Vaccines
Inducing Immune Responses Using Platelets
Brief Description: The use of patients own dendritic cells pulsed with a specific antigen to induce T-cells responses and induction of memory T-cells is widely known as an approach for stimulating the immune system in individualized medicine. This approach entails isolation of monocytes from the blood (where their numbers are relatively low) ...
Published: 10/12/2012   |   Inventor(s): Craig Morrell
Keywords(s): Antibacterial, Antiviral, Cancer, Infection, Infectious Disease, Research Tool
Category(s): Vaccines, Therapeutic
A Novel Approach to S.mutans Diagnostics, Therapeutic Intervention and Vaccines
Brief Description: Streptococcus mutans (S.mutans) is a major pathogen commonly found in the human oral cavity and is associated with dental caries. Dissemination of oral bacteria into the bloodstream is very common in patients subjected to dental procedures. S.mutans, if presents in the bloodstream, is suspected as a leading causative agent...
Published: 5/26/2011   |   Inventor(s): Jacqueline Abranches, Jose Lemos, Robert Burne
Keywords(s): Antibacterial, Caries, Dental, Diagnostic, Endocarditis, Gene, Infection, Infectious Disease, Oral
Category(s): Therapeutic
New Class of Antifungal Agents
Applications:New structural and mechanistic classes of antifungal therapeutics are needed to improve treatment options and to counter increasing resistance to currently used agents. In addition, there is no effective oral alternatives available to date. This invention identifies and validates the mechanistic characterization of PDK1 inhibitors as n...
Published: 9/20/2010   |   Inventor(s): Damian Krysan, Louis Didone, Bonnie Baxter
Keywords(s): Antifungal, Infection, Infectious Disease
Category(s): Therapeutic
Novel Autoinducer Molecules and Uses Therefore (Quinoline Signaling in the Cell-to-Cell Communication)
ApplicationsTherapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signaling in bacteria using the compounds of the invention are also described.AdvantagesThis technology allows th...
Published: 6/17/2009   |   Inventor(s): Barbara Iglewski, Pesci Everett, Jared Milbank, James Pearson, Andrew Kende, Everett Greenberg
Keywords(s): Infectious Disease, Therapy
Category(s): Therapeutic