Search Results - richard+moore

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Septin inhibitors for treatment of cancer
Background Effective therapeutic options are limited for the treatment of liver, lung, renal, ovarian, endometrial and pancreatic cancer. Successive second- and third-line therapies do not add meaningful responses besides adding numerous life-debilitating toxicities. In order to improve the survival rate of patients diagnosed with these lethal malignancies,...
Published: 11/21/2022   |   Inventor(s): Richard Moore, Rakesh Singh, Kyu Kwang Kim, Rachael Turner
Keywords(s):  
Category(s): Therapeutic
Small molecule inhibitor of human epididymis protein 4 (HE4) for treating cancer
­Background Epithelial ovarian cancer (EOC), is the fifth leading cause of cancer deaths in women, and the deadliest of all gynecologic cancers. The response of current chemotherapies has plateaued, creating a severe unmet need for superior therapies. Human epididymis protein 4 (HE4) is inordinately overexpressed in over 70% of EOC patients, acts...
Published: 11/21/2022   |   Inventor(s): Richard Moore, Rakesh Singh, Kyu Kwang Kim
Keywords(s):  
Category(s): Therapeutic
Small molecule for the treatment of malignancies and immune disorders
­Background More than 23.5 million Americans (>7% of the population) are the existing or emerging consumers of drugs targeting autoimmune diseases alone not including immune-dependent malignancies, and the prevalence is rising. The global autoimmune disease therapeutics market size alone can exceed $125 billion by the year 2025. Similarly, immune...
Published: 12/12/2022   |   Inventor(s): Rakesh Singh, Richard Moore, Laura Calvi, Michael Becker
Keywords(s):  
Category(s): Therapeutic
URML-3881, a Novel MEK Inhibitor for the Treatment of Cancers
Provided herein, are compounds, compositions, and methods of treatment of cancers using an inhibitor of MAPK/ERK Kinase (MEK), in particular hydrazine derivatives.
Published: 11/21/2022   |   Inventor(s): Richard Moore, Rakesh Singh, Rachael Turner, Kyu Kwang Kim, Negar Khazan
Keywords(s):  
Category(s): Therapeutic
Therapy for Malignant Disease
Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a...
Published: 11/21/2022   |   Inventor(s): Richard Moore, Rakesh Singh, Naohiro Yano
Keywords(s):  
Category(s): Therapeutic
Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method...
Published: 11/21/2022   |   Inventor(s): Rakesh Singh, Richard Moore
Keywords(s):  
Category(s): Therapeutic