Search Results - richard moore

3 Results Sort By:
URML-3881, a Novel MEK Inhibitor for the Treatment of Cancers
Provided herein, are compounds, compositions, and methods of treatment of cancers using an inhibitor of MAPK/ERK Kinase (MEK), in particular hydrazine derivatives.
Published: 11/6/2019   |   Inventor(s): Richard Moore, Rakesh Singh, Rachael Turner, Kyu Kwang Kim, Negar Khazan
Keywords(s):  
Category(s): Therapeutic
Therapy for Malignant Disease
Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a...
Published: 11/5/2019   |   Inventor(s): Richard Moore, Rakesh Singh, Naohiro Yano
Keywords(s):  
Category(s): Therapeutic
Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method...
Published: 11/5/2019   |   Inventor(s): Rakesh Singh, Richard Moore
Keywords(s):  
Category(s): Therapeutic