Search Results - rakesh singh

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URML-3881, a Novel MEK Inhibitor for the Treatment of Cancers
Provided herein, are compounds, compositions, and methods of treatment of cancers using an inhibitor of MAPK/ERK Kinase (MEK), in particular hydrazine derivatives.
Published: 11/6/2019   |   Inventor(s): Richard Moore, Rakesh Singh, Rachael Turner, Kyu Kwang Kim, Negar Khazan
Keywords(s):  
Category(s): Therapeutic
Therapy for Malignant Disease
Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a...
Published: 11/5/2019   |   Inventor(s): Richard Moore, Rakesh Singh, Naohiro Yano
Keywords(s):  
Category(s): Therapeutic
Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method...
Published: 11/5/2019   |   Inventor(s): Rakesh Singh, Richard Moore
Keywords(s):  
Category(s): Therapeutic
N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
This invention comprises the innovative synthesis of N-amino tetrahydrothiazine free bases and their salts. This invention further comprises the use of the derivatives and their therapeutic application as anticancer agents. Further this invention comprises their manufacture and use.
Published: 11/5/2019   |   Inventor(s): Rakesh Singh, Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler
Keywords(s):  
Category(s): Therapeutic