process of mRNA decay, such as the Staufen1 (STAU1)-mediated mRNA decay (SMD),
is integral to the post transcriptional control of genes that have been shown to be involved in a number of
diseases. Alu elements are the most prominent repeats in the human genome: they
constitute more than 10% of the human genome. The inventors report novel roles
for Alu elements and lncRNAs whereby SMD is activated upon the formation of
STAU1-binding sites (SBS).
inhibition of SMD could be useful in upregulating physiologic transcripts, in
disease states caused by the lack of sufficient functional
involvement of SMD in modulating the expression of oncogenic, proto-oncogenic,
angiogenic and immunologic transcripts makes it an attractive target for
pharmacological manipulation and future therapeutic development.