Manipulating mRNA Decay Pathway to Regulate Gene Expression

Brief Description

Brief Description:

The process of mRNA decay, such as the Staufen1 (STAU1)-mediated mRNA decay (SMD), is integral to the post transcriptional control of genes that have  been shown to be involved in a number of diseases. Alu elements are the most prominent repeats in the human genome: they constitute more than 10% of the human genome. The inventors report novel roles for Alu elements and lncRNAs whereby SMD is activated upon the formation of STAU1-binding sites (SBS).

Applications:

Isolated inhibition of SMD could be useful in upregulating physiologic transcripts, in disease states caused by the lack of sufficient functional protein. 

Advantages:

The involvement of SMD in modulating the expression of oncogenic, proto-oncogenic, angiogenic and immunologic transcripts makes it an attractive target for pharmacological manipulation and future therapeutic development.

 

Patent Information:
Title Country Patent No. Issued Date
Methods and Compositions Related to Staufen 1 Binding Sites Formed By Duplexing ALU Elements United States 9,206,479 12/8/2015
For Information, Contact:
Weimin Kaufman
Licensing Manager
University of Rochester
585.276.6608
weimin.kaufman@rochester.edu
Inventors:
Lynne Maquat
Chenguang Gong
Keywords:
Gene Expression
Gene Silencing
RNA