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Compact High NA All-Reflective Microscope Objectives
All-reflective, chromatic aberration-free microscope objective enabling ultra-broadband imaging without color distortions Institute Reference: 2-24031 Background High numerical aperture (NA) objectives are essential in optical microscopy, especially for biological and medical imaging, where high resolution and clarity are required. Traditional objectives...
Published: 10/22/2024
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Inventor(s):
Jannick Rolland-Thompson
,
Aaron Bauer
Keywords(s):
Category(s):
Optics
,
Research Tools
Spatio-Temporal-Angular Beam Multiplexer for Writing Refractive Index Changes in Optical Materials
Laser beam multiplexer for enhanced refractive index writing in ocular tissues, boosting efficiency and control in laser eye surgery Institute Reference: 2-20087 Background Ophthalmic and optical materials often require fine-tuned modifications in refractive index to improve visual performance. Conventional methods for writing refractive index changes...
Published: 10/22/2024
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Inventor(s):
Wayne Knox
Keywords(s):
Category(s):
Surgical/Medical Device
,
Optics
,
Research Tools
Single-shot, Adaptive Metrology of Rotationally Variant Optical Surfaces Using a Spatial Light Modulator
Adaptive interferometric metrology for testing complex, rotationally variant optical surfaces like freeform mirrors Institute Reference: 2-18037 Background Traditional metrology techniques for optical surfaces such as spherical and flat optics typically use full-field interferometry, but they struggle to measure complex, rotationally variant surfaces...
Published: 10/21/2024
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Inventor(s):
Jannick Rolland-Thompson
,
Romita Chaudhuri
Keywords(s):
Category(s):
Optics
,
Research Tools
Compact Freeform Echelle Spectrometer
A compact echelle spectrometer using freeform optics for high-resolution, UV spectral imaging with minimized optical aberrations Institute Reference: 2-17028 Background Atomic spectroscopy relies on precise wavelength selection to determine the concentration of specific elements in a sample. Conventional spectrometers face trade-offs between high...
Published: 10/21/2024
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Inventor(s):
Jannick Rolland-Thompson
,
Aaron Bauer
,
Mahsa Farsad
,
Dennis Yates
Keywords(s):
Category(s):
Optics
,
Research Tools
Denoising Algorithm for Sets of Evoked Potentials
Denoising Algorithm for Sets of Evoked Potentials A mathematical algorithm that denoises separately measured evoked potentials. Institute Reference: 2-23107 Background Evoked potentials are measured brain responses to some stimulus typically measured on the scalp using electroencephalography (EEG) electrodes. Measuring evoked potential serves many...
Published: 7/22/2024
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Inventor(s):
Ross Maddox
Keywords(s):
Category(s):
Research Tools
,
Diagnostic
Platform of engineered tRNAs that target and suppress disease caused by nonsense mutations
Background Nonsense mutations, or premature termination codons (PTCs), make up 10-15% of all genetic diseases, affecting over 30 million people worldwide through 7,000 different diseases. Currently, there are very limited options for their therapeutic management. Some of the available agents have significant issues such as off-target toxicity and low...
Published: 10/28/2024
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Inventor(s):
John Lueck
,
Joseph Porter
,
Charles Thornton
,
Wooree Ko
Keywords(s):
Category(s):
Research Tools
A practice management system designed to give valuable clinical and business insights to healthcare providers
Technology Overview ProVOS (Provider Value Optimization System) is a practice management system designed to provide both health care institutions and individual providers delivering care with valuable clinical and business insights. Leadership of healthcare organizations can utilize the system to monitor health yield per cost, as well as evaluate...
Published: 5/7/2024
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Inventor(s):
Kostantinos Vasalos
,
Kathleen Fear
Keywords(s):
Category(s):
Research Tools
,
Diagnostic
Improved Fibronectin Scaffolds for Artificial Antibody
Applications:This technology demonstrates the utility of the fibronectin type III domain as a scaffold to discover novel high affinity binding proteins. The fibronectin type III domain is small, stable and its structure has been well characterized making it an attractive system. This technology has application in drug discovery and design.
Published: 8/14/2023
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Inventor(s):
Shohei Koide
Keywords(s):
Research Tool
Category(s):
Research Tools
Human Glandular Kallikrein (hK2)-Specific Monoclonal Antibodies that Enhance or Inhibit the Enzymatic Activity of hK2
Applications:hK2 is expressed primarily in the prostate, making it an attractive bio-marker for prostate cancer development. A panel of HK2-specific monoclonal antibodies was produced using a tumor-immunization strategy. Compositions, which may be monoclonal antibodies, are specific for hK2 relative to PSA. Compositions either enhance or inhibit...
Published: 10/28/2024
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Inventor(s):
John Frelinger
,
Terrence Fisher
,
Mary Ann Nocera-March
,
Edith Lord
Keywords(s):
Category(s):
Research Tools
Multimeric Nucleic Probes
The present invention provides detectably labeled RNA and DNA oligonucleotide multimers useful as diagnostic probes in medical, biological and chemical applications. A method for synthesizing DNA and RNA oligonucleotides, oligonucleotide multimers, and analogs, preferably those that are detectably labeled, is also provided. Oligonucleotide synthesis...
Published: 5/7/2024
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Inventor(s):
Eric Kool
Keywords(s):
Category(s):
Research Tools
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