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Treating Lysosomal Storage Disorders (LSDs)
A method of screening for therapeutic agents to treat LSDs and a specific group of agents discovered thus far. The in-vitro screening method is based on the ability of a potential agent to protect CNS precursor cells from the toxic effects of accumulating lipids in LSDs. The protection is measured by increasing cell survival rates, reducing suppres...
Published: 4/29/2019   |   Inventor(s): Mark Noble, Christopher Folts, Nicole Scott-Hewitt
Keywords(s): Metabolic Syndrome, Metabolism
Category(s): Research Tools
Improved Fibronectin Scaffolds for Artificial Antibody
Applications:This technology demonstrates the utility of the fibronectin type III domain as a scaffold to discover novel high affinity binding proteins. The fibronectin type III domain is small, stable and its structure has been well characterized making it an attractive system. This technology has application in drug discovery and design.
Published: 4/29/2019   |   Inventor(s): Shohei Koide
Keywords(s): Research Tool
Category(s): Research Tools
Human Glandular Kallikrein (hK2)-Specific Monoclonal Antibodies that Enhance or Inhibit the Enzymatic Activity of hK2
Applications:hK2 is expressed primarily in the prostate, making it an attractive bio-marker for prostate cancer development. A panel of HK2-specific monoclonal antibodies was produced using a tumor-immunization strategy. Compositions, which may be monoclonal antibodies, are specific for hK2 relative to PSA. Compositions either enhance or inhibit...
Published: 4/29/2019   |   Inventor(s): John Frelinger, Terrence Fisher, Mary Ann Nocera-March, Edith Lord
Keywords(s):  
Category(s): Research Tools
Circular DNA Vectors
The present invention provides methods for synthesis, and therapeutic use of DNA and RNA oligonucleotides and analogs. RNA oligonucleotides arc synthesized using a small, circular DNA template which lacks an RNA polymerase promoter sequence. The RNA synthesis is performed by combining a circular single-stranded oligonucleotide template with an effe...
Published: 4/29/2019   |   Inventor(s): Eric Kool
Keywords(s):  
Category(s): Research Tools
Multimeric Nucleic Probes
The present invention provides detectably labeled RNA and DNA oligonucleotide multimers useful as diagnostic probes in medical, biological and chemical applications. A method for synthesizing DNA and RNA oligonucleotides, oligonucleotide multimers, and analogs, preferably those that are detectably labeled, is also provided. Oligonucleotide synthesi...
Published: 4/29/2019   |   Inventor(s): Eric Kool
Keywords(s):  
Category(s): Research Tools
Use of a Heme Tag for Expressed Protein Purification, Visualization, and Quantitation
The heme tag is a heme convalently bound to a peptide appended to a protein of interest. It's used for 1) affinity purification of a protein. 2) Visual tracking of a protein during expression and purification 3) quantization of a protein using absorption spectroscopy 4) determination of a protein?s extinction coefficient at 280nm.Applications:This ...
Published: 4/25/2019   |   Inventor(s): Kara Bren, Wesley Asher
Keywords(s):  
Category(s): Research Tools
The Myotonic Dystrophy Type-1 Health Index (MDHI Type-1) Italian Translation
The Myotonic Dystrophy Health Index (MDHI) Italian Version is a survey designed to efficiently measure the overall level of disease burden in a patient with myotonic dystrophy type-1 whose native language is Italian. This disease-specific patient-reported outcome measure is designed is designed to reliably and responsively measure therapeutic benef...
Published: 4/15/2019   |   Inventor(s): Chad Heatwole
Keywords(s):  
Category(s): Copyright, Informatics, Research Tools
A Functional Monoclonal Antibody Against DC-STAMP
Brief Description: Bone is a very dynamic organ as evidenced by the process of bone remodeling which relies on a delicate balance between bone formation and bone resorption and is orchestrated by osteoblasts (OB) and osteoclasts (OC). The coordinated interplay of OB and OC continuously remodels bone through highly regulated molecular and cellul...
Published: 7/24/2018   |   Inventor(s): Kofi Mensah, Yahui Grace Chiu, Christopher Ritchlin, Edward Schwarz
Keywords(s): Antibody, Anti-inflammatory, Inflammation, Orthopaedics, Osteoporosis, Reagent
Category(s): Research Tools
The Charcot-Marie-Tooth Disease Health Index (CMT-HI)
The CMT-Health Index (CMT-HI) is a disease-specific, patient-reported, outcome measure designed to reliably and responsively measure therapeutic benefit in Charcot-Marie-Tooth disease (CMT) clinical trials. The CMT-HI may also be used to measure overall patient health in a clinical setting. It covers the 18 areas of greatest importance to the adult...
Published: 6/30/2016   |   Inventor(s): Chad Heatwole, David Herrmann, Nicholas Johnson
Keywords(s):  
Category(s): Copyright, Informatics, Research Tools
The Myotonic Dystrophy Health Index Short Form (MDHI-SF)
The Myotonic Dystrophy Health Index Short Form (MDHI-SF) is a brief survey designed to efficiently measure the overall level of disease burden in a patient with myotonic dystrophy type-1. It covers the 17 areas of greatest importance to the adult myotonic dystrophy population. This instrument was developed and validated through the outcome measures...
Published: 6/30/2016   |   Inventor(s): Chad Heatwole
Keywords(s):  
Category(s): Copyright, Informatics, Research Tools
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