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A Functional Monoclonal Antibody Against DC-STAMP
Brief Description: Bone is a very dynamic organ as evidenced by the process of bone remodeling which relies on a delicate balance between bone formation and bone resorption and is orchestrated by osteoblasts (OB) and osteoclasts (OC). The coordinated interplay of OB and OC continuously remodels bone through highly regulated molecular and cellul...
Published: 7/24/2018   |   Inventor(s): Kofi Mensah, Yahui Grace Chiu, Christopher Ritchlin, Edward Schwarz
Keywords(s): Antibody, Anti-inflammatory, Inflammation, Orthopaedics, Osteoporosis, Reagent
Category(s): Research Tools
Preoperative Planning Document To Facilitate Correlation of IVUS and CT Scan Measurements For Placement Of IVUS-Guided IVC Filters
Preoperative planning document for the single puncture intravasular ultrasound (IVUS) guided bedside placement of IVC filters. Application Pulmonary Embolism (PE) has been reported in over 350,000 patients per year, with an estimated annual mortality rate of 240,000. Vena cava filtration is being used as an effective means of prophylaxis against PE...
Published: 3/9/2015   |   Inventor(s): David Gillespie, Sean Hislop
Keywords(s):  
Category(s): Copyright, Informatics, Research Tools
Heavy Atom Labeled acyl-CoA
A novel protocol to produce large quantities of nearly 100% homogenous heavy-labeled acyl-CoAs rapidly and inexpensively.Problem Solved by this TechnologyIndividual heavy atom-labeled acyl-CoAs are currently available made-to-order through several companies or are being generated in-house in labs as needed. The production of a full battery of acyl-...
Published: 8/4/2014   |   Inventor(s): David Goldfarb, Ian Blair
Keywords(s):  
Category(s): Materials, Research Tools
Methods and Compositions for the Preparation of Conformationally Constrained Peptide-Containing Molecules
The technology presents general methods for generating large, combinatorial libraries of structurally diverse macrocyclic compounds with a hybrid peptide/non-peptidic backbone.ApplicationsThe methodologies of this invention can be used for the discovery and development of small molecules with tailored binding affinity for therapeutic or biotechnolo...
Published: 4/9/2014   |   Inventor(s): Rudi Fasan
Keywords(s):  
Category(s): Research Tools
The Fascioscapulohumeral Muscular Dystrophy Health Index (FSHDI)
The Fascioscapulohumeral Muscular Dystrophy Health Index (FSHDI) is a disease-specific, patient reported outcome measure for FSHDI. Each question in the FSHDI was selected based on its relevance to a large muscular dystrophy population, its ability to be consistently understood by patients, its reliability during test-retest evaluation, its content...
Published: 10/9/2013   |   Inventor(s): Chad Heatwole
Keywords(s):  
Category(s): Copyright, Research Tools
Methods and Reagents for Site-Specific Labeling of Peptides and Proteins
Brief Description: Methods for site-specific protein functionalization find a broad range of applications in the context of protein detection, imaging, and purification, in the development of improved protein-based therapeutics (e.g. via PEGylation), and in the preparation of protein microarrays. This invention describes a new chemical method...
Published: 8/27/2013   |   Inventor(s): Rudi Fasan, John Frost
Keywords(s):  
Category(s): Research Tools
Methods and Systems for Predicting the Reactivity of Mono-Oxygenase Enzymes
ApplicationsThis technology provides methods for rapidly finding selective and highly active P450-based oxidation catalysts for the oxyfunctionalization (i.e. hydroxylation, epoxidation) of a target organic molecule. This method is particularly useful for developing synthetic procedures that enable the functional elaboration of a high-value compoun...
Published: 8/27/2013   |   Inventor(s): Rudi Fasan, Kai -Dong Zhang
Keywords(s):  
Category(s): Research Tools
The Myotonic Dystrophy Health Index (MDHI)
The Myotonic Dystrophy Health Index (MDHI) is a disease-specific, patient reported outcome measure for myotonic dystrophy type-1 (DM1). Each question in the MDHI was selected based on its relevance to a large DM1 population, its ability to be consistently understood by patients, its reliability during test-retest evaluation, its content validity, ...
Published: 3/22/2013   |   Inventor(s): Chad Heatwole
Keywords(s):  
Category(s): Copyright, Research Tools, Computer Software, Informatics
Methods of Studying Human and Non-Human Epidermal
Brief Description: The technology developed herein describes methods to study barrier properties and function of fully stratified, intact epidermal samples from both healthy and diseased subjects. Epidermal samples are isolated by using a Weck blade and are relatively free of dermis. Without the technique described herein, such measurements we...
Published: 7/19/2012   |   Inventor(s): Lisa Beck, Anna De Benedetto
Keywords(s):  
Category(s): Research Tools
Manipulating mRNA Decay Pathway to Regulate Gene Expression
Brief Description: The process of mRNA decay, such as the Staufen1 (STAU1)-mediated mRNA decay (SMD), is integral to the post transcriptional control of genes that have been shown to be involved in a number of diseases. Alu elements are the most prominent repeats in the human genome: they constitute more than 10% of the human genome. The in...
Published: 3/2/2012   |   Inventor(s): Lynne Maquat, Chenguang Gong
Keywords(s): Gene Expression, Gene Silencing, RNA
Category(s): Therapeutic, Research Tools
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