Search Results - lynne maquat

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Macrocyclic Inhibitors of the Human PGC1ß-CBP80 Protein-Protein Interaction
The invention provides compositions and methods for inhibiting protein- protein interactions with cap-binding protein 80 (CBP80). In one embodiment, the invention provides compositions comprising linear and macrocylic peptides. In one embodiment, the invention provides methods for treating cancer, heart disease, autoimmune disorders, obesity, diabetes,...
Published: 11/6/2019   |   Inventor(s): Lynne Maquat, Rudi Fasan
Category(s): Therapeutic
Manipulating mRNA Decay Pathway to Regulate Gene Expression
Brief Description: The process of mRNA decay, such as the Staufen1 (STAU1)-mediated mRNA decay (SMD), is integral to the post transcriptional control of genes that have been shown to be involved in a number of diseases. Alu elements are the most prominent repeats in the human genome: they constitute more than 10% of the human genome. The inventors...
Published: 3/2/2012   |   Inventor(s): Lynne Maquat, Chenguang Gong
Keywords(s): Gene Expression, Gene Silencing, RNA
Category(s): Therapeutic, Research Tools