Search Results - rna

2 Results Sort By:
Method to Prevent HIV Infection by Maintaining APOBEC3G (A3g) in Its More Active “Low Molecular Mass” (LMM) Form
Applications:The more active LMM form of APOBEC3G (A3g) prevents HIV from replicating within the host. Thus maintaining LMM-A3G and preventing the inactive HMM-A3G formation or preventing its degradation by the viral protein, Vif, would limit the ability of HIV to infect its host.Advantages:This technology provides a novel approach to increase the activity...
Published: 4/29/2019   |   Inventor(s): Harold Smith, Joseph Wedekind
Keywords(s): AIDS, Antiviral, HIV, RNA, Therapy
Category(s): Therapeutic
Manipulating mRNA Decay Pathway to Regulate Gene Expression
Brief Description: The process of mRNA decay, such as the Staufen1 (STAU1)-mediated mRNA decay (SMD), is integral to the post transcriptional control of genes that have been shown to be involved in a number of diseases. Alu elements are the most prominent repeats in the human genome: they constitute more than 10% of the human genome. The inventors...
Published: 3/2/2012   |   Inventor(s): Lynne Maquat, Chenguang Gong
Keywords(s): Gene Expression, Gene Silencing, RNA
Category(s): Therapeutic, Research Tools