Search Results - rudi fasan

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Parthenolide Derivatives, Methods for Their Preparation and Their Use as Anticancer Agents
Brief Description:The plant-derived natural product parthenolide was recently found to possess potent in vitro and in vivo antitumor activity against leukemia and many other human malignancies, including breast, lung, prostate, liver, brain, pancreas, and bone cancer. This invention describes synthetic methodologies that enable the functionalizatio...
Published: 4/25/2019   |   Inventor(s): Rudi Fasan, Craig Jordan, Joshua Kolev
Keywords(s):  
Category(s): Therapeutic
Macrocyclic Peptidomimetics for Alpha-Helix Mimicry
Brief Description: The technology presents novel macrocyclic peptidomimetic molecules and a method to generate these molecules for targeting alpha-helix-mediated protein-protein and protein-nucleic acid interactions. Applications: This methodology can be employed for the development of low molecular-weight molecules for therapeutic or biote...
Published: 4/9/2014   |   Inventor(s): Rudi Fasan
Keywords(s):  
Category(s): Therapeutic
Methods and Compositions for Ribosomal Synthesis of Macrocyclic Peptides
Brief Description: The technology presents a general method to generate cyclic peptides from recombinant genetically encoded polypeptide precursors. Applications: This methodology can be employed for the discovery and development of small molecules with tailored binding affinity for therapeutic or biotechnological applications. Specifically...
Published: 4/9/2014   |   Inventor(s): Rudi Fasan
Keywords(s):  
Category(s): Therapeutic
Methods and Compositions for the Preparation of Conformationally Constrained Peptide-Containing Molecules
The technology presents general methods for generating large, combinatorial libraries of structurally diverse macrocyclic compounds with a hybrid peptide/non-peptidic backbone.ApplicationsThe methodologies of this invention can be used for the discovery and development of small molecules with tailored binding affinity for therapeutic or biotechnolo...
Published: 4/9/2014   |   Inventor(s): Rudi Fasan
Keywords(s):  
Category(s): Research Tools
Artemisinin Derivatives, Methods For Their Preparation And Their Use As Antimalarial Agents
Brief Description: The present invention relates to novel derivatives of the antimalarial artemisinin, methods and compositions for their preparation, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections (primarily malaria). Advantages: Despite their viability of semisynthetic artemisinin as antimal...
Published: 8/27/2013   |   Inventor(s): Rudi Fasan, Kai -Dong Zhang
Keywords(s):  
Category(s): Therapeutic
Methods and Reagents for Site-Specific Labeling of Peptides and Proteins
Brief Description: Methods for site-specific protein functionalization find a broad range of applications in the context of protein detection, imaging, and purification, in the development of improved protein-based therapeutics (e.g. via PEGylation), and in the preparation of protein microarrays. This invention describes a new chemical method...
Published: 8/27/2013   |   Inventor(s): Rudi Fasan, John Frost
Keywords(s):  
Category(s): Research Tools
Methods and Systems for Predicting the Reactivity of Mono-Oxygenase Enzymes
ApplicationsThis technology provides methods for rapidly finding selective and highly active P450-based oxidation catalysts for the oxyfunctionalization (i.e. hydroxylation, epoxidation) of a target organic molecule. This method is particularly useful for developing synthetic procedures that enable the functional elaboration of a high-value compoun...
Published: 8/27/2013   |   Inventor(s): Rudi Fasan, Kai -Dong Zhang
Keywords(s):  
Category(s): Research Tools