A Model to Study the Role of IL-1ß in Neurodegeneration and Brain Injury

Brief Description
Applications:
A novel transgenic mouse model was created to investigate the role of IL1ß in neurodegeration and brain injury. This model may also be used to test existing and novel drugs and therapies for suppression of neuroinflammation associated with brain disorders.

Advantages:
Creation of conditionally expressed IL1ß and IL-1A (receptor antagonist) mice provides an important tool for dissection of the role of IL-1 in brain and newrodegeration.
Patent Information:
Category(s):
Research Tools
For Information, Contact:
Daisy Bunbury
Licensing Manager
University of Rochester
 
Inventors:
M. Kerry O'Banion
Stephanos Kyrkanides
Keywords:
Alzheimer's
Research Tool