A Model to Study the Role of IL-1ß in Neurodegeneration and Brain Injury
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A novel transgenic mouse model was created to investigate the role of IL1ß in neurodegeration and brain injury. This model may also be used to test existing and novel drugs and therapies for suppression of neuroinflammation associated with brain disorders.
Creation of conditionally expressed
IL1ß and IL-1A (receptor antagonist) mice provides an important tool for dissection of the role of IL-1 in brain and newrodegeration.
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University of Rochester
M. Kerry O'Banion
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