Mice Carrying Null or Conditional Mutations in the Bambi Gene

Brief Description
Applications:
The Bambi gene encodes an inhibitory pseudoreceptor for the Bmp/TGF-beta super-family of signaling molecules. The Bambi mutant mice will be useful for research and drug development for cardiovascular and musculoskeletal diseases, stem cell biology and cancer biology, liver function and homeostasis, immune system modulation, etc.

Advantages:
This is the first reported mutant mouse strain with mutation in the Bambi gene.  Moreover, the mouse was generated with a conditioned mutation and allows cell type specific and development time specific inactivation of the gene, enabling detailed and unbiased analysis of the effects on specific cell types at the desired developemtn or physiological stages.
  
Patent Information:
Category(s):
Research Tools
For Information, Contact:
Daisy Bunbury
Licensing Manager
University of Rochester
 
Inventors:
Rulang Jiang
Jianquan Chen
Jeffrey Bush
Keywords:
Mouse
Research Tool