Mice Carrying Null or Conditional Mutations in the Bambi Gene
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gene encodes an inhibitory pseudoreceptor for the Bmp/TGF-beta super-family of signaling molecules. The
mutant mice will be useful for research and drug development for cardiovascular and musculoskeletal diseases, stem cell biology and cancer biology, liver function and homeostasis, immune system modulation, etc.
This is the first reported mutant mouse strain with mutation in the
gene. Moreover, the mouse was generated with a conditioned mutation and allows cell type specific and development time specific inactivation of the gene, enabling detailed and unbiased analysis of the effects on specific cell types at the desired developemtn or physiological stages.
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