Mice Carrying Null or Conditional Mutations in the Bambi Gene

The Bambi gene encodes an inhibitory pseudoreceptor for the Bmp/TGF-beta super-family of signaling molecules. The Bambi mutant mice will be useful for research and drug development for cardiovascular and musculoskeletal diseases, stem cell biology and cancer biology, liver function and homeostasis, immune system modulation, etc.

This is the first reported mutant mouse strain with mutation in the Bambi gene.  Moreover, the mouse was generated with a conditioned mutation and allows cell type specific and development time specific inactivation of the gene, enabling detailed and unbiased analysis of the effects on specific cell types at the desired development or physiological stages.

URV Reference Number: 6-1747
Patent Information:
Research Tools
For Information, Contact:
Daisy Bunbury
Licensing Manager
University of Rochester
Rulang Jiang
Jianquan Chen
Jeffrey Bush
Research Tool