is a common degenerative joint disease and currently there is no effective
treatment for the diseases. We have generated a conditional activation genetic
mouse model that can help to identify new drugs for the prevention and treatment
of osteoarthritis. The mouse model can also test the effect and efficacy of
existing or newly identified osteoarthritis drugs.
the mouse model, we demonstrate for the first time that over expression of a key
gene in articular chondrocytes leads to the development of OA in adult