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3' Deoxy Nucleosides and Their Analogs as Anti-HIV Agents Targeting HIV-1 Macrophage Infection

Published: 4/29/2019 | Inventor(s): Baek Kim

Keywords(s): Antiviral, Drug Design, HIV, Infectious Disease

Category(s): Therapeutic

Novel HIV Therapeutic Approach: Targeting APOBEC-3G(A3G):RNA Complexes

Brief Description:APOBEC-3G (A3G) is a cytidine deaminase enzyme that interferes with the replication of HIV and other retroviruses by mutating viral nucleic acids, thus playing an important role in innate anti-viral immunity. Viral infectivity factor (Vif) is a protein found in HIV and other retroviruses which disrupts the antiviral activity of the...

Published: 4/29/2019 | Inventor(s): Harold Smith, Kimberly Prohaska, William McDougall

Keywords(s): AIDS, Antiviral, HIV, Infectious Disease, Therapy, Viral disease

Category(s): Therapeutic

Methods for Production of a Solution Assay and High-Throughput Screen to Probe the Interaction Between the Human Cullin-RING Ligase Complex and the HIV-1 Protein on a Muti-Milligram Scale

Brief Description:HIV-1 infection leads to the expression of the viral Vif protein which is essential to evade the host’s own A3G and A3F defense factors. Vif works in concert with the cell’s own ubiquitin ligase machinery to promote degradation of A3G and A3F. This requires a direct interaction between Vif and the human proteins Elongin...

Published: 4/29/2019 | Inventor(s): Jason Salter, Joseph Wedekind, Harold Smith

Keywords(s): AIDS, Antiviral, Combinatorial Chemistry, Drug Design, HIV, HTS, Infection, Infectious Disease, Target Validation, Therapy, Viral disease

Category(s): Therapeutic