Search Results - infectious+disease

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3' Deoxy Nucleosides and Their Analogs as Anti-HIV Agents Targeting HIV-1 Macrophage Infection
3' Deoxy Nucleosides and Their Analogs as Anti-HIV Agents Targeting HIV-1 Macrophage Infection
Published: 4/29/2019   |   Inventor(s): Baek Kim
Keywords(s): Antiviral, Drug Design, HIV, Infectious Disease
Category(s): Therapeutic
Novel HIV Therapeutic Approach: Targeting APOBEC-3G(A3G):RNA Complexes
Brief Description:APOBEC-3G (A3G) is a cytidine deaminase enzyme that interferes with the replication of HIV and other retroviruses by mutating viral nucleic acids, thus playing an important role in innate anti-viral immunity. Viral infectivity factor (Vif) is a protein found in HIV and other retroviruses which disrupts the antiviral activity of the...
Published: 4/29/2019   |   Inventor(s): Harold Smith, Kimberly Prohaska, William McDougall
Keywords(s): AIDS, Antiviral, HIV, Infectious Disease, Therapy, Viral disease
Category(s): Therapeutic
Methods for Production of a Solution Assay and High-Throughput Screen to Probe the Interaction Between the Human Cullin-RING Ligase Complex and the HIV-1 Protein on a Muti-Milligram Scale
Brief Description:HIV-1 infection leads to the expression of the viral Vif protein which is essential to evade the host’s own A3G and A3F defense factors. Vif works in concert with the cell’s own ubiquitin ligase machinery to promote degradation of A3G and A3F. This requires a direct interaction between Vif and the human proteins Elongin...
Published: 4/29/2019   |   Inventor(s): Jason Salter, Joseph Wedekind, Harold Smith
Keywords(s): AIDS, Antiviral, Combinatorial Chemistry, Drug Design, HIV, HTS, Infection, Infectious Disease, Target Validation, Therapy, Viral disease
Category(s): Therapeutic
Vaccine against Pneumocystis and Streptococcal Infections
Novel polypeptides and immunogenic conjugates capable of inducing passive and active immunity against Pneumocystis carinii and Streptococcus pneumoniae infections.Problem Solved by this TechnologyPneumocystis pneumonia (PCP), caused by an opportunistic pathogen Pneumocystis carinii, is a significant cause of morbidity and mortality in immunocompromised...
Published: 9/21/2016   |   Inventor(s): Francis Gigliotti, Terry Wright, Constantine Haidaris, Patricia Simpson-Haidaris
Keywords(s): Antibody, Infectious Disease, Therapy
Category(s): Vaccines
New Class of Antifungal Agents
Applications:New structural and mechanistic classes of antifungal therapeutics are needed to improve treatment options and to counter increasing resistance to currently used agents. In addition, there is no effective oral alternatives available to date. This invention identifies and validates the mechanistic characterization of PDK1 inhibitors as novel...
Published: 9/20/2010   |   Inventor(s): Damian Krysan, Louis Didone, Bonnie Baxter
Keywords(s): Antifungal, Infection, Infectious Disease
Category(s): Therapeutic
Novel Autoinducer Molecules and Uses Therefore (Quinoline Signaling in the Cell-to-Cell Communication)
ApplicationsTherapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signaling in bacteria using the compounds of the invention are also described.AdvantagesThis technology allows the...
Published: 6/17/2009   |   Inventor(s): Barbara Iglewski, Pesci Everett, Jared Milbank, James Pearson, Andrew Kende, Everett Greenberg
Keywords(s): Infectious Disease, Therapy
Category(s): Therapeutic