Search Results - Vaccines

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Reorganization of Arenavirus Genome for Development of Novel Arenavirus Live-Attenuated Vaccines (LAV)

Disclosed are compositions and methods related to recombinant arenaviruses and their use in vaccines for the treatment or prevention of an arenavirus infection.

Published: 8/14/2023 | Inventor(s): Juan Carlos De La Torre, Luis Martinez-Sobrido, Masaharu Iwasaki, Beatrice Cubitt

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Category(s): Vaccines

Improved Live Attenuated Flu Vaccine

Novel methodologies to engineer an improved and a more effective live attenuated flu vaccine.Problem Solved by this TechnologyCurrent flu vaccinations (injection-based inactivated influenza virus and recombinant influenza virus vaccines) are suboptimal as they generate limited cellular-mediated immune responses. Additionally, particularly vulnerable...

Published: 8/14/2023 | Inventor(s): Andrew Cox, Stephen Dewhurst

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Category(s): Vaccines

Vaccine against Pneumocystis and Streptococcal Infections

Novel polypeptides and immunogenic conjugates capable of inducing passive and active immunity against Pneumocystis carinii and Streptococcus pneumoniae infections.Problem Solved by this TechnologyPneumocystis pneumonia (PCP), caused by an opportunistic pathogen Pneumocystis carinii, is a significant cause of morbidity and mortality in immunocompromised...

Published: 5/23/2023 | Inventor(s): Francis Gigliotti

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Category(s): Vaccines

Improved Safer Nasal Spray Flu Vaccines

A novel live attenuated influenza virus nasal vaccine safe enough for use by young children and asthmatics.Problem Solved by this TechnologyYoung children, pregnant women, and persons with compromised immune systems are at high risk for complications arising from an influenza infection. These people are currently served with sub-dermal, or nasal applications...

Published: 8/14/2023 | Inventor(s): Stephen Dewhurst, Andrew Cox, John Treanor, Baek Kim

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Category(s): Vaccines

Development of Arenavirus Vaccines through Codon Deoptimization

A novel strategy for developing live-attenuated arenavirus vaccines. Problem Solved by the TechnologyArenaviruses have a significant impact on public health and pose a credible threat to biodefense.There are four arenaviruses that cause severe hemorrhagic fever in humans (Lassa virus, endemic to Africa; and Machupo, Junin, and Guanarito viruses endemic...

Published: 5/23/2023 | Inventor(s): Luis Martinez-Sobrido, Juan Carlos De La Torre

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Category(s): Vaccines

Novel Human Papillomavirus (HPV) Chimeric Virus Like Particle (cVLP)-Based Gene Delivery System for Phrophylaxis and Immunotherapy of Infectious Diseases

Applications:As demonstrated in vitro and in vivo results, HPV VLPs, preferably chimeric HPV L1/L2 VLPs, are useful for facilitating delivery and expression of plasmid DNA to antigen presenting cells, and for enhanced induction of immune responses against co-administered plasmid DNA-based immunogens. Results also demonstrate enhanced immune response...

Published: 10/5/2023 | Inventor(s): Robert Rose, Christine Malboeuf, Youngeun Ellen Lee Son, Christopher Lane

Keywords(s): Vaccine

Category(s): Vaccines

Stabilized Outersurface Protein A Fragment as a Lyme Disease Vaccine

ApplicationsLyme disease is a tick-borne infection caused by the spirochete Borrelia burgdorferi that can result in damages to joints, cardiovascular and nervous systems. Outsurface protein A (OspA) is a major surface antigen of Borrelia burgdorferi. Anti- OspA mAb has been shown to protect severe combined immunodeficiency mice from clinical symptoms...

Published: 5/23/2023 | Inventor(s): Shohei Koide, Benjamin Luft, John Dunn, Catherine Lawson

Keywords(s): Vaccine

Category(s): Vaccines

Stable Human Fc Receptor-Transformed Cell Lines to Detect Virus-Neutralizing and Enhancing Antibodies

Applications:The invention offers a novel method to screen anti-flavivirus antibodies in blood for neutralizing and replication-enhancing antibodies using Fc gamma R transformed macrophages. Although this invention is immediately applicable to dengue virus infection, in principle it is applicable to any viral pathogen whose replication may be enhanced...

Published: 5/23/2023 | Inventor(s): Jacob Schlesinger, Robert Rose, W.W. Shanaka Rodrigo, Xia Jin

Keywords(s): Vaccine

Category(s): Vaccines