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Novel Human Papillomavirus (HPV) Chimeric Virus Like Particle (cVLP)-Based Gene Delivery System for Phrophylaxis and Immunotherapy of Infectious Diseases
Applications:As demonstrated in vitro and in vivo results, HPV VLPs, preferably chimeric HPV L1/L2 VLPs, are useful for facilitating delivery and expression of plasmid DNA to antigen presenting cells, and for enhanced induction of immune responses against co-administered plasmid DNA-based immunogens. Results also demonstrate enhanced immune response...
Published: 5/7/2024
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Inventor(s):
Robert Rose
,
Christine Malboeuf
,
Youngeun Ellen Lee Son
,
Christopher Lane
Keywords(s):
Vaccine
Category(s):
Vaccines
Stable Human Fc Receptor-Transformed Cell Lines to Detect Virus-Neutralizing and Enhancing Antibodies
Applications:The invention offers a novel method to screen anti-flavivirus antibodies in blood for neutralizing and replication-enhancing antibodies using Fc gamma R transformed macrophages. Although this invention is immediately applicable to dengue virus infection, in principle it is applicable to any viral pathogen whose replication may be enhanced...
Published: 10/28/2024
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Inventor(s):
Jacob Schlesinger
,
Robert Rose
,
W.W. Shanaka Rodrigo
,
Xia Jin
Keywords(s):
Vaccine
Category(s):
Vaccines