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RNA-Targeted Small Molecules as Potential Antiviral Therapy (HIV, SARS etc)
Brief Description: A high error rate of HIV -I reverse transcriptase coupled with a fast replication cycle associated with HIV -1 favors rapid development and selection of drug resistant strains. Therefore, identification of small molecules capable of inhibiting viral components necessary for HIV -1 proliferation continues to be of great importance....
Published: 10/28/2024
|
Inventor(s):
Benjamin Miller
,
Brian Mcnaughton
,
Peter Gareiss
,
Joseph Wedekind
Keywords(s):
AIDS
,
HIV
,
Small Molecule
,
Therapy
Category(s):
Therapeutic
Protease Activated Cytokines as Anti-Cancer Therapy
A novel therapy method for delivering localized anti-cancer responses without adverse body-wide side effects. Problem Solved by the Technology Despite remarkable success at identifying tumor-associated antigens (TAA), generating effective anti-tumor immune response has not been successful at eliminating tumors. Systemically administered active drugs...
Published: 10/28/2024
|
Inventor(s):
John Frelinger
,
John Puskas
,
Baek Kim
,
Mark Sullivan
Keywords(s):
Cancer
,
Immunotherapy
,
Oncology
,
Therapy
Category(s):
Therapeutic
Human Monoclonal Antibodies for Prevention and Treatment of Influenza Virus Infections
Background Seasonal influenza, also referred to as influenza or flu, is a contagious respiratory viral illness. Influenza infection varies in severity, causing asymptomatic infection to fatal disease, particularly for high-risk patient populations such as the elderly (over 65 years of age), young children (under five years of age), pregnant women,...
Published: 10/28/2024
|
Inventor(s):
James Kobie
,
Luis Martinez-Sobrido
,
Michael Piepenbrink
,
Aitor Nogales-Gonzalez
Keywords(s):
Category(s):
Therapeutic
Human Monoclonal Antibodies for Prevention and Treatment of Influenza Virus Infections
Background Seasonal influenza, also referred to as influenza or flu, is a contagious respiratory viral illness. Influenza infection varies in severity, causing asymptomatic infection to fatal disease, particularly for high-risk patient populations such as the elderly (over 65 years of age), young children (under five years of age), pregnant women,...
Published: 10/28/2024
|
Inventor(s):
James Kobie
,
Luis Martinez-Sobrido
,
Aitor Nogales-Gonzalez
,
Michael Piepenbrink
Keywords(s):
Category(s):
Therapeutic
Treatment of caries using probiotics
Background Dental caries, also known as tooth decay or cavity is one of the world's most common oral health problems today. According to the World Health Organization (WHO), 60%-90% of school-aged children and nearly 100% of adults worldwide have dental cavities. They can affect people in a variety of ways, including infections, tooth pain, stunting...
Published: 10/28/2024
|
Inventor(s):
Jin Xiao
Keywords(s):
Category(s):
Therapeutic
New GsMTx4D- conjugates for joint-injury-induced osteoarthritis treatment
Background Arthritis presently impacts more than fifty million adults, plaguing one in five Americans with the number one cause of disability in the U.S. Examples of current treatments against arthritis include intra-articular injections of hyaluronic acid or corticosteroids, but these treatments are limited to providing short term pain relief...
Published: 5/7/2024
|
Inventor(s):
Whasil Lee
,
Thomas Suchyna
Keywords(s):
Category(s):
Therapeutic
New
Therapeutic
Target and Strategy to Enhance Tendon Mechanical Properties
Background The tendon is a highly collagenous connective tissue that transmits forces from muscle to bone to enable movement. Tendons are also prone to injury. Unfortunately, tendons have an exceptionally slow natural healing process and typically exhibit abnormal and inferior mechanical properties once healed. In addition, tendons are commonly associated...
Published: 5/7/2024
|
Inventor(s):
Catherine Kuo
Keywords(s):
Category(s):
Therapeutic
Novel, Synthetic Peptides that Inhibit the Formation of Tight Junctions
Background Current methods of vaccination primarily rely on intramuscular, subcutaneous, and intradermal injection of antigens. These vaccination routes, while effective, require medical personnel to deliver, generate biohazards (sharps) requiring costly disposal, and cause patients pain and anxiety. This has fueled research efforts to identify “needle-free”...
Published: 5/7/2024
|
Inventor(s):
Benjamin Miller
,
Lisa Beck
,
Matthew Brewer
Keywords(s):
Category(s):
Therapeutic
Epigenetic Methylation inhibitors displaying anti-tumor activity
Background Diffuse intrinsic pontine glioma (DIPG) is a lethal malignant tumor that arises from the middle portion of the brain stem and usually affects children with a poor prognosis, as there are no surgical options for providing relief to patients. Conventional chemotherapy as well as radiation therapy provide minimal life extension and palliative...
Published: 5/7/2024
|
Inventor(s):
Frank (Hal) Ebetino
,
Venkatesan Srinivasan
,
Rintaro Hashizume
,
Robert Boeckman, Jr.
Keywords(s):
Category(s):
Therapeutic
Gene Therapy for Reflux Disease in the Esophagus
Background Almost one-third of adults in the US experience symptoms of gastroesophageal reflux disease (GERD) and patients with chronic GERD have an increased risk for the development of esophageal adenocarcinoma. Although proton pump inhibitors (PPIs) have shown effective treatment for GERD, up to 45% of patients with GERD remain symptomatic on standard...
Published: 10/28/2024
|
Inventor(s):
David Dean
,
Zhongren (David) Zhou
Keywords(s):
Category(s):
Therapeutic
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