Search Results - david+dean

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Gene Therapy for Reflux Disease in the Esophagus

Background Almost one-third of adults in the US experience symptoms of gastroesophageal reflux disease (GERD) and patients with chronic GERD have an increased risk for the development of esophageal adenocarcinoma. Although proton pump inhibitors (PPIs) have shown effective treatment for GERD, up to 45% of patients with GERD remain symptomatic on standard...

Published: 5/23/2023 | Inventor(s): David Dean, Zhongren (David) Zhou

Keywords(s):

Category(s): Therapeutic

Method to upregulate epithelial and endothelial barrier function in the injured lung

Background Epithelial and endothelial barriers are essential to life. While the endothelium lines the vasculature and ensures tissue supply with nutrients and oxygen, the epithelium forms the barrier between tissues and the outer environment thus protecting organs from invading harmful agents. Dysfunction in the epithelial or endothelial barrier...

Published: 8/14/2023 | Inventor(s): David Dean

Keywords(s):

Category(s): Therapeutic