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Method for the suppression of transcripts escaping from nonsense-mediated mRNA decay

Background One-third of inherited human diseases are caused by mutated mRNAs harboring premature termination codons (PTCs). Nonsense-mediated mRNA decay (NMD) is a critical cellular surveillance mechanism that recognizes and eliminates aberrant RNAs containing PTC. NMD plays an important role in cell cycle regulation, cell viability, and DNA damage...

Published: 9/19/2023 | Inventor(s): Lynne Maquat, Tatsuaki Kurosaki

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Category(s): Therapeutic