Search Results - shohei+koide

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Improved Fibronectin Scaffolds for Artificial Antibody

Applications:This technology demonstrates the utility of the fibronectin type III domain as a scaffold to discover novel high affinity binding proteins. The fibronectin type III domain is small, stable and its structure has been well characterized making it an attractive system. This technology has application in drug discovery and design.

Published: 8/14/2023 | Inventor(s): Shohei Koide

Keywords(s): Research Tool

Category(s): Research Tools

Stabilized Outersurface Protein A Fragment as a Lyme Disease Vaccine

ApplicationsLyme disease is a tick-borne infection caused by the spirochete Borrelia burgdorferi that can result in damages to joints, cardiovascular and nervous systems. Outsurface protein A (OspA) is a major surface antigen of Borrelia burgdorferi. Anti- OspA mAb has been shown to protect severe combined immunodeficiency mice from clinical symptoms...

Published: 5/23/2023 | Inventor(s): Shohei Koide, Benjamin Luft, John Dunn, Catherine Lawson

Keywords(s): Vaccine

Category(s): Vaccines