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Novel Human Papillomavirus (HPV) Chimeric Virus Like Particle (cVLP)-Based Gene Delivery System for Phrophylaxis and Immunotherapy of Infectious Diseases

Applications:As demonstrated in vitro and in vivo results, HPV VLPs, preferably chimeric HPV L1/L2 VLPs, are useful for facilitating delivery and expression of plasmid DNA to antigen presenting cells, and for enhanced induction of immune responses against co-administered plasmid DNA-based immunogens. Results also demonstrate enhanced immune response...

Published: 10/5/2023 | Inventor(s): Robert Rose, Christine Malboeuf, Youngeun Ellen Lee Son, Christopher Lane

Keywords(s): Vaccine

Category(s): Vaccines

Stabilized Outersurface Protein A Fragment as a Lyme Disease Vaccine

ApplicationsLyme disease is a tick-borne infection caused by the spirochete Borrelia burgdorferi that can result in damages to joints, cardiovascular and nervous systems. Outsurface protein A (OspA) is a major surface antigen of Borrelia burgdorferi. Anti- OspA mAb has been shown to protect severe combined immunodeficiency mice from clinical symptoms...

Published: 5/23/2023 | Inventor(s): Shohei Koide, Benjamin Luft, John Dunn, Catherine Lawson

Keywords(s): Vaccine

Category(s): Vaccines

Stable Human Fc Receptor-Transformed Cell Lines to Detect Virus-Neutralizing and Enhancing Antibodies

Applications:The invention offers a novel method to screen anti-flavivirus antibodies in blood for neutralizing and replication-enhancing antibodies using Fc gamma R transformed macrophages. Although this invention is immediately applicable to dengue virus infection, in principle it is applicable to any viral pathogen whose replication may be enhanced...

Published: 5/23/2023 | Inventor(s): Jacob Schlesinger, Robert Rose, W.W. Shanaka Rodrigo, Xia Jin

Keywords(s): Vaccine

Category(s): Vaccines