A Mouse Line that Lacks Phosphoinositide

Applications
The invention generates a mouse line that is Phosphoinositide 3-Kinase g-deficient. The mouse model can be used in target validation assays for arthritis, asthma, septic shock, and atherosclerosis. 

Advantages
The mouse model can provide information as to which human disease might benefit from drugs designed to inhibit Phosphoinositide 3-Kinase g.