Stable Human Fc Receptor-Transformed Cell Lines to Detect Virus-Neutralizing and Enhancing Antibodies
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The invention offers a novel method to screen anti-flavivirus antibodies in blood for neutralizing and replication-enhancing antibodies using Fc gamma R transformed macrophages. Although this invention is immediately applicable to dengue virus infection, in principle it is applicable to any viral pathogen whose replication may be enhanced by antibodies.
The invention offers simplicity and the prospect of an automated, high through-put alternative to both conventional virus plaque neutralization and immune enhancement assay. The method will offer a standardized format to replace current laborious methods to measure protective neutralizing and potentially undesirable immune-enhancing antibodies stimulated by natural infection or by candidate and established viral vaccine.
Method of Determining Immune Enhancement of Virus Infectivity using FC Receptor-Transfected Cell Lines
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University of Rochester
W.W. Shanaka Rodrigo
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