Search Results - robert rose

3 Results Sort By:
Novel Human Papillomavirus (HPV) Chimeric Virus Like Particle (cVLP)-Based Gene Delivery System for Phrophylaxis and Immunotherapy of Infectious Diseases
Applications: As demonstrated in vitro and in vivo results, HPV VLPs, preferably chimeric HPV L1/L2 VLPs, are useful for facilitating delivery and expression of plasmid DNA to antigen presenting cells, and for enhanced induction of immune responses against co-administered plasmid DNA-based immunogens. Results also demonstrate enhanced immune re...
Published: 5/4/2009   |   Inventor(s): Robert Rose, Christine Malboeuf, Youngeun Ellen Lee Son, Christopher Lane
Keywords(s): Vaccine
Category(s): Vaccines
Transcutaneous Immunization Against Papillomavirus Disease
Brief Description: This invention is a method of vaccinating against human papillomavirus (HPV) by using papillomavirus ?virus-like particles? transcutaneously to induce an immune response to the virus. Applications: Papiloma viruses constitute a group of DNA viruses that induce both lytic infections and either benign or malignant tumors. Pap...
Published: 5/4/2009   |   Inventor(s): Robert Rose
Keywords(s): Vaccine
Category(s): Vaccines
Stable Human Fc Receptor-Transformed Cell Lines to Detect Virus-Neutralizing and Enhancing Antibodies
Applications: The invention offers a novel method to screen anti-flavivirus antibodies in blood for neutralizing and replication-enhancing antibodies using Fc gamma R transformed macrophages. Although this invention is immediately applicable to dengue virus infection, in principle it is applicable to any viral pathogen whose replication may be...
Published: 5/4/2009   |   Inventor(s): Jacob Schlesinger, Robert Rose, W.w. Shanaka Rodrigo, Xia Jin
Keywords(s): Vaccine
Category(s): Vaccines