Macrocyclic Peptide Phage Display
Background
Peptides represent a growing class of therapeutics with potential to treat different conditions such as diabetes and various forms of cancer. However, therapeutic peptides have two intrinsic drawbacks: poor cell permeability and susceptibility to proteolytic degradation, which represent major stumbling blocks for peptide drug development....
Published: 5/7/2024
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Inventor(s): Rudi Fasan, Andrew Owens, Jacob Iannuzzelli
Keywords(s):
Category(s): Therapeutic
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Production of cyclopeptibodies with high target affinity and specificity that can be used as a replacement for antibodies
Background
Antibodies find widespread use as therapeutic agents and for diagnostic, imaging, and immunodetection applications. Major limitations of antibodies, however, are their complex structure, limited stability, poor tissue penetration, complex manufacturing process, and associated high costs of production. Despite their numerous and important...
Published: 5/7/2024
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Inventor(s): Rudi Fasan, Yu Gu
Keywords(s):
Category(s): Therapeutic
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Structurally complex compounds exhibiting diverse anticancer activity profiles
Background
Natural products have historically provided a major source of drugs and therapeutic agents; for example, about 50% of anticancer drugs and 60% of antibacterial drugs are natural products or semisynthetic derivatives thereof. Skeletal diversity and high stereochemical content are well-known attributes that endow natural products with...
Published: 5/7/2024
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Inventor(s): Rudi Fasan, Andrew Bortz, John Bennett
Keywords(s):
Category(s): Materials
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Macrocyclic Peptidomimetics for Alpha-Helix Mimicry
Brief
Description:
The
technology presents novel macrocyclic peptidomimetic molecules and a method to
generate these molecules for targeting alpha-helix-mediated protein-protein and
protein-nucleic acid interactions.
Applications:
This
methodology can be employed for the development of low molecular-weight
molecules for therapeutic...
Published: 5/7/2024
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Inventor(s): Rudi Fasan
Keywords(s):
Category(s): Therapeutic
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Methods and Compositions for Ribosomal Synthesis of Macrocyclic Peptides
Brief
Description:
The
technology presents a general method to generate cyclic peptides from
recombinant genetically encoded polypeptide precursors.
Applications:
This
methodology can be employed for the discovery and development of small molecules
with tailored binding affinity for therapeutic or biotechnological applications.
Specifically,...
Published: 5/7/2024
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Inventor(s): Rudi Fasan
Keywords(s):
Category(s): Therapeutic
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Methods and Compositions for the Preparation of Conformationally Constrained Peptide-Containing Molecules
The technology presents general methods for generating large, combinatorial libraries of structurally diverse macrocyclic compounds with a hybrid peptide/non-peptidic backbone.ApplicationsThe methodologies of this invention can be used for the discovery and development of small molecules with tailored binding affinity for therapeutic or biotechnological...
Published: 5/7/2024
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Inventor(s): Rudi Fasan
Keywords(s):
Category(s): Research Tools
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Artemisinin Derivatives, Methods For Their Preparation And Their Use As Antimalarial Agents
Brief Description: The present invention
relates to novel derivatives of the antimalarial
artemisinin,
methods and compositions for their preparation, and their
uses in pharmaceutical compositions intended for the treatment of parasitic
infections (primarily malaria).
Advantages: Despite their viability of
semisynthetic artemisinin as...
Published: 5/7/2024
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Inventor(s): Rudi Fasan, Kai -Dong Zhang
Keywords(s):
Category(s): Therapeutic
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Methods and Reagents for Site-Specific Labeling of Peptides and Proteins
Brief
Description:
Methods
for site-specific protein functionalization find a broad range of applications
in the context of protein detection, imaging, and purification, in the
development of improved protein-based therapeutics (e.g. via PEGylation), and in
the preparation of protein microarrays. This invention describes a new chemical
method...
Published: 5/7/2024
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Inventor(s): Rudi Fasan, John Frost
Keywords(s):
Category(s): Research Tools
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