Search Results - rudi+fasan

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Macrocyclic Peptide Phage Display
­Background Peptides represent a growing class of therapeutics with potential to treat different conditions such as diabetes and various forms of cancer. However, therapeutic peptides have two intrinsic drawbacks: poor cell permeability and susceptibility to proteolytic degradation, which represent major stumbling blocks for peptide drug development....
Published: 8/5/2022   |   Inventor(s): Rudi Fasan, Andrew Owens, Jacob Iannuzzelli
Keywords(s):  
Category(s): Therapeutic
Production of cyclopeptibodies with high target affinity and specificity that can be used as a replacement for antibodies
Background Antibodies find widespread use as therapeutic agents and for diagnostic, imaging, and immunodetection applications. Major limitations of antibodies, however, are their complex structure, limited stability, poor tissue penetration, complex manufacturing process, and associated high costs of production. Despite their numerous and important...
Published: 8/5/2022   |   Inventor(s): Rudi Fasan, Yu Gu
Keywords(s):  
Category(s): Therapeutic
Structurally complex compounds exhibiting diverse anticancer activity profiles
­Background Natural products have historically provided a major source of drugs and therapeutic agents; for example, about 50% of anticancer drugs and 60% of antibacterial drugs are natural products or semisynthetic derivatives thereof. Skeletal diversity and high stereochemical content are well-known attributes that endow natural products with...
Published: 8/5/2022   |   Inventor(s): Rudi Fasan, Andrew Bortz, John Bennett
Keywords(s):  
Category(s): Materials
Macrocyclic Peptidomimetics for Alpha-Helix Mimicry
Brief Description: The technology presents novel macrocyclic peptidomimetic molecules and a method to generate these molecules for targeting alpha-helix-mediated protein-protein and protein-nucleic acid interactions. Applications: This methodology can be employed for the development of low molecular-weight molecules for therapeutic or biotechnological...
Published: 6/1/2021   |   Inventor(s): Rudi Fasan
Keywords(s):  
Category(s): Therapeutic
Methods and Compositions for Ribosomal Synthesis of Macrocyclic Peptides
Brief Description: The technology presents a general method to generate cyclic peptides from recombinant genetically encoded polypeptide precursors. Applications: This methodology can be employed for the discovery and development of small molecules with tailored binding affinity for therapeutic or biotechnological applications. Specifically,...
Published: 6/1/2021   |   Inventor(s): Rudi Fasan
Keywords(s):  
Category(s): Therapeutic
Methods and Compositions for the Preparation of Conformationally Constrained Peptide-Containing Molecules
The technology presents general methods for generating large, combinatorial libraries of structurally diverse macrocyclic compounds with a hybrid peptide/non-peptidic backbone.ApplicationsThe methodologies of this invention can be used for the discovery and development of small molecules with tailored binding affinity for therapeutic or biotechnological...
Published: 6/1/2021   |   Inventor(s): Rudi Fasan
Keywords(s):  
Category(s): Research Tools
Artemisinin Derivatives, Methods For Their Preparation And Their Use As Antimalarial Agents
Brief Description: The present invention relates to novel derivatives of the antimalarial artemisinin, methods and compositions for their preparation, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections (primarily malaria). Advantages: Despite their viability of semisynthetic artemisinin as antimalarial...
Published: 6/1/2021   |   Inventor(s): Rudi Fasan, Kai -Dong Zhang
Keywords(s):  
Category(s): Therapeutic
Methods and Reagents for Site-Specific Labeling of Peptides and Proteins
Brief Description: Methods for site-specific protein functionalization find a broad range of applications in the context of protein detection, imaging, and purification, in the development of improved protein-based therapeutics (e.g. via PEGylation), and in the preparation of protein microarrays. This invention describes a new chemical method...
Published: 6/1/2021   |   Inventor(s): Rudi Fasan, John Frost
Keywords(s):  
Category(s): Research Tools
Methods and Systems for Predicting the Reactivity of Mono-Oxygenase Enzymes
ApplicationsThis technology provides methods for rapidly finding selective and highly active P450-based oxidation catalysts for the oxyfunctionalization (i.e. hydroxylation, epoxidation) of a target organic molecule. This method is particularly useful for developing synthetic procedures that enable the functional elaboration of a high-value compound...
Published: 6/1/2021   |   Inventor(s): Rudi Fasan, Kai -Dong Zhang
Keywords(s):  
Category(s): Research Tools