Search Results - maiken+nedergaard

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Method for using cerebrospinal fluid to deliver gene therapeutics to the inner ear and rescue hearing
Background An estimated 2.45 billion of individuals are predicted to have mild-to-complete hearing impairment by 2050. Current ameliorating therapy using hearing aids or cochlear implants remain insufficient in restoring the full capacities of auditory function. Gene therapy has shown promising results in animal models but the delivery of genetic material...
Published: 12/12/2022   |   Inventor(s): Maiken Nedergaard, Barbara Mathiesen, Barbara Canlon, Christopher Cederroth
Keywords(s):  
Category(s): Therapeutic
Method for improving delivery of immunotherapeutic agents to the CNS
­Background Up to 1 billion people, suffer from neurological disorders, from Alzheimer (AD) and Parkinson disease, strokes, multiple sclerosis and epilepsy to migraine, brain injuries and neuroinfections. Most therapies fail mainly due to the poor penetration of the blood-brain barrier (BBB). Therefore, improving the delivery of drugs to the CNS...
Published: 11/21/2022   |   Inventor(s): Maiken Nedergaard, Benjamin Plog, Humberto Mestre, Tuomas Olavi Lilius, Andreas Tue Ingemann Jensen, Steven Goldman
Keywords(s):  
Category(s): Therapeutic