Silk-based ophthalmic devices use femtosecond laser technology to enable biocompatible, customizable vision correction solutions
Institute Reference: 2-24012
Background
Femtosecond micromachining has gained traction as a precise tool for inducing refractive index (RI) changes in transparent materials. This technique has been applied to ophthalmic materials such as contact lenses and intraocular lenses (IOLs) for vision correction. However, a challenge remains in finding a biocompatible, stable material for long-term use in the eye. Silk fibroin, a structural protein derived from silkworms, offers an ideal solution due to its transparency, biocompatibility, and FDA approval for medical use.
Technology Overview
This innovation focuses on creating ophthalmic devices made primarily of silk fibroin, modified using Laser-Induced Refractive Index Change (LIRIC). The process uses femtosecond lasers to precisely alter the refractive index of silk-based hydrogel materials, allowing for customized vision correction patterns without damaging the material. The technology enables the formation of gradient index (GRIN) lenses or other refractive structures directly in contact lenses, corneal inlays, and IOLs.
Benefits
Silk fibroin, a naturally derived material, is highly biocompatible with ocular tissues, making it an ideal choice for ophthalmic applications. Its integration with femtosecond laser technology allows for precise modifications to the refractive index, enabling the customization of vision correction to meet individual needs. Additionally, silk fibroin offers an environmentally friendly alternative to synthetic polymers, reducing the impact of microplastics on health and the environment. The durability of silk-based devices ensures they remain stable over time, providing consistent and reliable vision correction for long-term use.
Applications
Silk-based ophthalmic devices offer versatile solutions for a range of vision correction needs. For contact lenses, custom laser-written refractive patterns can address common issues such as myopia, hyperopia, and astigmatism, providing precise and personalized vision correction. Intraocular lenses (IOLs), both traditional and phakic, are used in cataract surgery or refractive lens exchange to deliver multifocal or extended depth-of-focus vision, improving clarity at multiple distances. Additionally, fully biocompatible silk corneal inlays provide a suitable solution for presbyopia, offering a tissue-additive alternative to traditional laser ablation surgeries; which in combination with LIRIC can be customized to provide the optimal refractive profile to the patient.
Opportunity
The University of Rochester is open to exploring funded research collaborations, licensing agreements, and other partnership opportunities.