Novel Treatment for Acute and Traumatic Nerve Injury

Brief description:

This invention provides a novel method for the localized and effective administration of a small molecule for the treatment of acute peripheral nerve injuries.

 

Applications:

Injury to the peripheral nerves can occur through a variety of trauma.  Common causes of these injuries include: laceration, focal contusion (gunshot wounds), stretch/traction injury, compression, and others. Depending on the severity, blunt trauma treatment consists mostly of observation since nerve function can return with time.  Often, immobilization, non-steroidal anti-inflammatory medications/NSAIDS, and pain medications such as acetaminophen are administered. Penetrating trauma that involves a transection of the nerve will likely require surgical repair, when possible. In all cases, recovery typically takes many months. Dr. Elfar and his laboratory have described, in vivo, a locally administered small molecule that decreases recovery times significantly.

 

Advantages:

The described molecule when formulated with novel encapsulation techniques can deliver effective dosing regimens to the specific site of nerve injury over a prescribed duration. This approach is favored over competing drug therapies, which have relied on systemic administration or observation where recoveries can take months.

URV Reference Number: 6-2164
Patent Information:
Category(s):
Therapeutic
For Information, Contact:
Matan Rapoport
Licensing Associate
University of Rochester
585.276.6600
matan.rapoport@rochester.edu
Inventors:
John Elfar
Mark Noble
Kuang-Ching Tseng
Keywords:
Neurological
Orthopaedics