Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production

Applications:
The invention is a method of enhancing endogenous interleukin-10 production in mammalian cells and tissues, which includes administering an effective amount of a tetracycline derivative.

Advantages:
The method also includes enhancing interleukin-10 production by administering an effective amount of the tetracycline derivative to a mammal. Preferred tetracycline compounds are tetracycline compounds which have been modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by excessive IL-1 and TNF alpha production.

URV Reference Number: 6-0825
Patent Information:
Category(s):
Therapeutic
For Information, Contact:
Matan Rapoport
Licensing Associate
University of Rochester
585.276.6600
matan.rapoport@rochester.edu
Inventors:
Lorne Golub
Christopher Ritchlin
Robert Greenwald
Sally Haas
Susan Moak
Hsi-Ming Lee
Keywords:
Infectious Disease
Therapy