Retinal Imaging with Adaptive Optics Optical Coherence Tomography (AO-OCT)

Brief Description
Adaptive optics is used in optical coherence tomography (OCT) to provide very high axial resolution in a non-invasive "optical sectioning" technique for imaging at various depths within living human tissue. In the current commercial application of OCT for retinal imaging, the transverse resolution is limited by the intrinsic ocular aberrations of the eye.   This invention applies adaptive optics via a deformable mirror and wavefront sensor to correct for those aberrations.

Retinal imaging is used to diagnose diseases of the eye.  

Axial resolution down to a few microns has been obtained in the living human retina.  Lateral resolution, which is limited by the blurring effects of diffraction and aberrations in the optics of the eye, can be significantly improved by correcting the aberrations across a large pupil using adaptive optics.  AO-OCT can be realized with 1D, 2D, and 3D imaging using either a scanning spot or flood illumination.

Technology Status
This technology is being developed at Indiana University by Prof. Donald Miller, who was previously at the University of Rochester.  The technology is now assigned to the University of Rochester.
Patent Information:
Title Country Patent No. Issued Date
Method and Apparatus for Improving Both Lateral and Axial Resolution in Ophthalmoscopy United States 7,364,296 4/29/2008
For Information, Contact:
Zubair Mirza
Senior Manager, Physical Sciences
University of Rochester
Donald Miller
Junle Qu
Ravi Jonnal
Karen Thorn
in vivo